P04181: Ornithine aminotransferase, mitochondrial

General Information

Protein names	- Ornithine aminotransferase, mitochondrial - 2.6.1.13 - Ornithine delta-aminotransferase - Ornithine--oxo-acid aminotransferase - Ornithine aminotransferase, hepatic form - Ornithine aminotransferase, renal form
Gene names	OAT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04181

7 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY GAHNYHPLPV
        70         80         90        100        110        120
ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA LKSQVDKLTL TSRAFYNNVL
       130        140        150        160        170        180
GEYEEYITKL FNYHKVLPMN TGVEAGETAC KLARKWGYTV KGIQKYKAKI VFAAGNFWGR
       190        200        210        220        230        240
TLSAISSSTD PTSYDGFGPF MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV
       250        260        270        280        290        300
PDPGYLMGVR ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP
       310        320        330        340        350        360
VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD KLGIILRNEL
       370        380        390        400        410        420
MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN GLLAKPTHGD IIRFAPPLVI
       430
KEDELRESIE IINKTILSF

Isoforms

- Isoform 2 of Ornithine aminotransferase, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04181-18-unknown	VHSSVA...	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26465
P04181-18-unknown	VHSSVA...	18		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P04181-18-	VHSSVA...	18		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P04181-18-	VHSSVA...	18		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P04181-18-	VHSSVA...	18		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P04181-18-	VHSSVA...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04181-18-	VHSSVA...	18		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04181-18-	VHSSVA...	18		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P04181-18-	VHSSVA...	18		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04181-26-unknown	TSVATK...	26	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04181-36-unknown	GPPTSD...	36	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04181-36-unknown	GPPTSD...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7194
P04181-121-unknown	GEYEEY...	121	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7195
P04181-139-unknown	MNTGVE...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83622
P04181-283-unknown	VRPDIV...	283	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17089
P04181-283-unknown	VRPDIV...	283	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144542

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VLSRGV	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26465
...KKTVQG	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7194
...YNNVLG	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7195
...VDYENV	282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17089
...VDYENV	282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127809
...TILSF	439	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TILSF	439	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79240

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MPPB_HUMAN	17	SRGV.\|.VHSS	inferred from experiment	unknown	MEROPS	Ito A	Kitada S et al.:A protein from a parasitic micr... (M16.003)	17158683,
CATS_HUMAN	35	TVQG.\|.GPPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	120	NVLG.\|.GEYE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	282	YENV.\|.VRPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)