Q16595: Frataxin, mitochondrial

General Information

Protein names	- Frataxin, mitochondrial - 1.16.3.1 - Friedreich ataxia protein - Fxn - Frataxin intermediate form - i-FXN - Frataxin(56-210) - m56-FXN - Frataxin(78-210) - d-FXN - m78-FXN - Frataxin mature form - Frataxin(81-210) - m81-FXN
Gene names	FXN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16595

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Frataxin, mitochondrial - Isoform 3 of Frataxin, mitochondrial

Sequence View

        10         20         30         40         50         60
MWTLGRRAVA GLLASPSPAQ AQTLTRVPRP AELAPLCGRR GLRTDIDATC TPRRASSNQR
        70         80         90        100        110        120
GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFF EDLADKPYTF
       130        140        150        160        170        180
EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV
       190        200        210
SLHELLAAEL TKALKTKLDL SSLAYSGKDA         10         20         30         40         50         60
MWTLGRRAVA GLLASPSPAQ AQTLTRVPRP AELAPLCGRR GLRTDIDATC TPRRASSNQR
        70         80         90        100        110        120
GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFF EDLADKPYTF
       130        140        150        160        170        180
EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV
       190        200        210
SLHELLAAEL TKALKTKLDL SSLAYSGKDA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16595-1-unknown	MWTLGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75447
Q16595-1-unknown	MWTLGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75448
Q16595-42-unknown	LRTDID...	42	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16595-42-unknown	LRTDID...	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26481
Q16595-42-unknown	LRTDID...	42	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115463
Q16595-42-unknown	LRTDID...	42	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115464
Q16595-56-unknown	SSNQRG...	56	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16595-56-unknown	SSNQRG...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26484
Q16595-56-unknown	SSNQRG...	56	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115694
Q16595-56-unknown	SSNQRG...	56	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115695
Q16595-78-unknown	LRKSGT...	78	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16595-78-unknown	LRKSGT...	78	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115802
Q16595-78-unknown	LRKSGT...	78	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115803
Q16595-81-unknown	SGTLGH...	81	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16595-81-unknown	SGTLGH...	81		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q16595-81-unknown	SGTLGH...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115818
Q16595-81-unknown	SGTLGH...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115819
Q16595-81-	SGTLGH...	81		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q16595-81-	SGTLGH...	81		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q16595-81-	SGTLGH...	81		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16595-81-	SGTLGH...	81		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CGRRGL	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26481
...CGRRGL	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121557
...CGRRGL	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121558
...TPRRAS	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26484
...TPRRAS	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122699
...TPRRAS	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122700
...SGKDA	210	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MPPB_HUMAN	41	RRGL.\|.LRTD	inferred from experiment	unknown	MEROPS	Isaya G	Cavadini P et al.:Two-step processing of human fr... (M16.003)	11020385,
MPPB_HUMAN	55	RRAS.\|.SSNQ	inferred from experiment	unknown	MEROPS	Isaya G	Cavadini P et al.:Two-step processing of human fr... (M16.003)	11020385,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)