P07954: Fumarate hydratase, mitochondrial {ECO:0000303|PubMed:21445611, ECO:0000303|PubMed:27037871}

General Information

Protein names	- Fumarate hydratase, mitochondrial {ECO:0000303\|PubMed:21445611, ECO:0000303\|PubMed:27037871} - Fumarase {ECO:0000303\|PubMed:27037871, ECO:0000303\|PubMed:3828494, ECO:0000303\|Ref.2} - HsFH {ECO:0000303\|PubMed:24419633} - 4.2.1.2 {ECO:0000269\|PubMed:30761759}
Gene names	FH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07954

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYRALRLLAR SRPLVRAPAA ALASAPGLGG AAVPSFWPPN AARMASQNSF RIEYDTFGEL
        70         80         90        100        110        120
KVPNDKYYGA QTVRSTMNFK IGGVTERMPT PVIKAFGILK RAAAEVNQDY GLDPKIANAI
       130        140        150        160        170        180
MKAADEVAEG KLNDHFPLVV WQTGSGTQTN MNVNEVISNR AIEMLGGELG SKIPVHPNDH
       190        200        210        220        230        240
VNKSQSSNDT FPTAMHIAAA IEVHEVLLPG LQKLHDALDA KSKEFAQIIK IGRTHTQDAV
       250        260        270        280        290        300
PLTLGQEFSG YVQQVKYAMT RIKAAMPRIY ELAAGGTAVG TGLNTRIGFA EKVAAKVAAL
       310        320        330        340        350        360
TGLPFVTAPN KFEALAAHDA LVELSGAMNT TACSLMKIAN DIRFLGSGPR SGLGELILPE
       370        380        390        400        410        420
NEPGSSIMPG KVNPTQCEAM TMVAAQVMGN HVAVTVGGSN GHFELNVFKP MMIKNVLHSA
       430        440        450        460        470        480
RLLGDASVSF TENCVVGIQA NTERINKLMN ESLMLVTALN PHIGYDKAAK IAKTAHKNGS
       490        500        510
TLKETAIELG YLTAEQFDEW VKPKDMLGPK

Isoforms

- Isoform Cytoplasmic of Fumarate hydratase, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07954-44-unknown	MASQNS...	44	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75539
P07954-45-	ASQNSF...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P07954-45-	ASQNSF...	45		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P07954-45-	ASQNSF...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07954-45-	ASQNSF...	45		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P07954-45-unknown	ASQNSF...	45	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07954-45-unknown	ASQNSF...	45	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26467
P07954-45-unknown	ASQNSF...	45	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115538
P07954-45-unknown	ASQNSF...	45	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P07954-351-	SGLGEL...	351		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P07954-351-unknown	SGLGEL...	351	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176161

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NAARMA	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26467
...MLGPK	510	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MLGPK	510	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71157

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MPPB_HUMAN	44	ARMA.\|.ASQN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)