P18859: ATP synthase-coupling factor 6, mitochondrial {ECO:0000305}

General Information

Protein names	- ATP synthase-coupling factor 6, mitochondrial {ECO:0000305} - ATPase subunit F6 - ATP synthase peripheral stalk subunit F6 {ECO:0000305}
Gene names	ATP5J
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18859

6 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP
70 80 90 100
VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF EVIEKPQA

Isoforms

- Isoform 2 of ATP synthase-coupling factor 6, mitochondrial

Sequence View

10 20 30 40 50 60
MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP
70 80 90 100
VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF EVIEKPQA

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18859-25-unknown	IGVTAV...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26469
P18859-25-unknown	IGVTAV...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137789
P18859-33-	NKELDP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P18859-33-	NKELDP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P18859-33-	NKELDP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
P18859-33-	NKELDP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P18859-33-	NKELDP...	33		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P18859-33-	NKELDP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P18859-33-	NKELDP...	33		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P18859-33-unknown	NKELDP...	33	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18859-33-unknown	NKELDP...	33		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P18859-33-unknown	NKELDP...	33		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P18859-33-unknown	NKELDP...	33	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115092
P18859-37-unknown	DPIQKL...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17416
P18859-37-unknown	DPIQKL...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18826
P18859-37-unknown	DPIQKL...	37	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138701
P18859-86-unknown	DMNTFP...	86	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18828
P18859-86-unknown	DMNTFP...	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142081
P18859-97-unknown	DPKFEV...	97	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18830
P18859-97-unknown	DPKFEV...	97	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142649

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HLRRNI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26469
...HLRRNI	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120790
...FNKELD	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17416
...FNKELD	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18826
...FNKELD	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121755
...MFGNAD	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18828
...MFGNAD	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125266
...TFKFED	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18830
...TFKFED	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125849
...EKPQA	108	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EKPQA	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63542

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MPPB_HUMAN	24	RRNI.\|.IGVT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
MEP1A_HUMAN	36	KELD.\|.DPIQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	36	KELD.\|.DPIQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	85	GNAD.\|.DMNT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	96	KFED.\|.DPKF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)