TopFIND 4.0

P09874: Poly [ADP-ribose] polymerase 1

General Information

Protein names
- Poly ADP-ribose] polymerase 1
- PARP-1
- 2.4.2.30 {ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:7852410}
- ADP-ribosyltransferase diphtheria toxin-like 1
- ARTD1
- DNA ADP-ribosyltransferase PARP1 {ECO:0000305}
- 2.4.2.- {ECO:0000269|PubMed:27471034}
- NAD(+) ADP-ribosyltransferase 1 {ECO:0000303|Ref.11}
- ADPRT 1 {ECO:0000303|Ref.11}
- PolyADP-ribose] synthase 1
- Protein poly-ADP-ribosyltransferase PARP1 {ECO:0000305}
- 2.4.2.- {ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:25043379}
Gene names PARP1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P09874

24

N-termini

9

C-termini

12

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV 
        70         80         90        100        110        120 
GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD GIGSKAEKTL GDFAAEYAKS 
       130        140        150        160        170        180 
NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ LGMIDRWYHP GCFVKNREEL GFRPEYSASQ 
       190        200        210        220        230        240 
LKGFSLLATE DKEALKKQLP GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA 
       250        260        270        280        290        300 
QNDLIWNIKD ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG 
       310        320        330        340        350        360 
QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV KKQDRIFPPE 
       370        380        390        400        410        420 
TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK LSRNKDEVKA MIEKLGGKLT 
       430        440        450        460        470        480 
GTANKASLCI STKKEVEKMN KKMEEVKEAN IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP 
       490        500        510        520        530        540 
WGAEVKAEPV EVVAPRGKSG AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE 
       550        560        570        580        590        600 
HSAHVLEKGG KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK 
       610        620        630        640        650        660 
LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE AVKKLTVNPG 
       670        680        690        700        710        720 
TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV 
       730        740        750        760        770        780 
SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KVEMLDNLLD IEVAYSLLRG 
       790        800        810        820        830        840 
GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE 
       850        860        870        880        890        900 
REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 
       910        920        930        940        950        960 
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA 
       970        980        990       1000       1010    
NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

24 N-termini - 9 C-termini - 12 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)