Q15233: Non-POU domain-containing octamer-binding protein

General Information

Protein names	- Non-POU domain-containing octamer-binding protein - NonO protein - 54 kDa nuclear RNA- and DNA-binding protein - 55 kDa nuclear protein - DNA-binding p52/p100 complex, 52 kDa subunit - NMT55 - p54(nrb) - p54nrb
Gene names	NONO
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15233

26 N-termini

8 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQSNKTFNLE KQNHTPRKHH QHHHQQQHHQ QQQQQPPPPP IPANGQQASS QNEGLTIDLK
        70         80         90        100        110        120
NFRKPGEKTF TQRSRLFVGN LPPDITEEEM RKLFEKYGKA GEVFIHKDKG FGFIRLETRT
       130        140        150        160        170        180
LAEIAKVELD NMPLRGKQLR VRFACHSASL TVRNLPQYVS NELLEEAFSV FGQVERAVVI
       190        200        210        220        230        240
VDDRGRPSGK GIVEFSGKPA ARKALDRCSE GSFLLTTFPR PVTVEPMDQL DDEEGLPEKL
       250        260        270        280        290        300
VIKNQQFHKE REQPPRFAQP GSFEYEYAMR WKALIEMEKQ QQDQVDRNIK EAREKLEMEM
       310        320        330        340        350        360
EAARHEHQVM LMRQDLMRRQ EELRRMEELH NQEVQKRKQL ELRQEEERRR REEEMRRQQE
       370        380        390        400        410        420
EMMRRQQEGF KGTFPDAREQ EIRMGQMAMG GAMGINNRGA MPPAPVPAGT PAPPGPATMM
       430        440        450        460        470
PDGTLGLTPP TTERFGQAAT MEGIGAIGGT PPAFNRAAPG AEFAPNKRRR Y

Isoforms

- Isoform 2 of Non-POU domain-containing octamer-binding protein

Sequence View

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Protein Neighborhood

Domains & Features

26 N-termini - 8 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15233-1-Acetylation	MQSNKT...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15233-6-	TFNLEK...	6			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q15233-45-	GQQASS...	45			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15233-45-	GQQASS...	45			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15233-45-	GQQASS...	45			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15233-53-unknown	EGLTID...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17981
Q15233-53-unknown	EGLTID...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19571
Q15233-67-unknown	EKTFTQ...	67		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q15233-90-unknown	MRKLFE...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83036
Q15233-131-unknown	NMPLRG...	131		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12355
Q15233-131-unknown	NMPLRG...	131		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138498
Q15233-177-unknown	AVVIVD...	177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170480
Q15233-177-	AVVIVD...	177			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15233-177-	AVVIVD...	177			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15233-177-	AVVIVD...	177			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15233-191-	GIVEFS...	191			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15233-191-	GIVEFS...	191			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15233-191-	GIVEFS...	191			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15233-191-	GIVEFS...	191			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15233-191-unknown	GIVEFS...	191		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166760
Q15233-328-unknown	ELHNQE...	328		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19572
Q15233-328-unknown	ELHNQE...	328		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7854
Q15233-328-unknown	ELHNQE...	328		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148021
Q15233-372-unknown	GTFPDA...	372		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6449
Q15233-372-unknown	GTFPDA...	372		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149411
Q15233-372-unknown	GTFPDA...	372		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15233-372-unknown	GTFPDA...	372		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q15233-388-	AMGGAM...	388			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15233-388-	AMGGAM...	388			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15233-388-	AMGGAM...	388			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15233-388-	AMGGAM...	388			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15233-388-	AMGGAM...	388			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15233-388-unknown	AMGGAM...	388		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166758
Q15233-390-	GGAMGI...	390			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15233-390-	GGAMGI...	390			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15233-390-unknown	GGAMGI...	390		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166762
Q15233-400-unknown	AMPPAP...	400		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173125
Q15233-400-	AMPPAP...	400			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15233-423-unknown	GTLGLT...	423		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1303
Q15233-423-unknown	GTLGLT...	423		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2212
Q15233-423-unknown	GTLGLT...	423		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150597
Q15233-436-	GQAATM...	436			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15233-436-unknown	GQAATM...	436		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173123
Q15233-442-unknown	EGIGAI...	442		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19574
Q15233-442-unknown	EGIGAI...	442		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151010
Q15233-445-unknown	GAIGGT...	445		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14528
Q15233-445-unknown	GAIGGT...	445		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151083
Q15233-457-unknown	AAPGAE...	457		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169954
Q15233-457-	AAPGAE...	457			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASSQNE	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17981
...ASSQNE	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19571
...KVELDN	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12355
...KVELDN	130	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121542
...LRRMEE	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19572
...LRRMEE	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7854
...LRRMEE	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131384
...QEGFKG	371	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6449
...QEGFKG	371	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132796
...TMMPDG	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1303
...TMMPDG	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2212
...TMMPDG	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133994
...QAATME	441	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19574
...QAATME	441	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134413
...TMEGIG	444	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14528
...TMEGIG	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134485
...KRRRY	471	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRRRY	471	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78654

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	52	SQNE.\|.EGLT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	52	SQNE.\|.EGLT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	130	ELDN.\|.NMPL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	327	RMEE.\|.ELHN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	327	RMEE.\|.ELHN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	371	GFKG.\|.GTFP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP1_HUMAN	422	MPDG.\|.GTLG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CASP3_HUMAN	422	MPDG.\|.GTLG	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
MEP1B_HUMAN	441	ATME.\|.EGIG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	444	EGIG.\|.GAIG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)