P62241: 40S ribosomal protein S8

General Information

Protein names	- 40S ribosomal protein S8 - Small ribosomal subunit protein eS8 {ECO:0000303\|PubMed:24524803}
Gene names	RPS8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62241

13 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL
        70         80         90        100        110        120
DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP
       130        140        150        160        170        180
LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS LLEEQFQQGK LLACIASRPG
       190        200
QCGRADGYVL EGKELEFYLR KIKARKGK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62241-2-unknown	GISRDN...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62241-2-	GISRDN...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62241-2-	GISRDN...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62241-27-	YELGRP...	27		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62241-29-unknown	LGRPAA...	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7635
P62241-32-	PAANTK...	32		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62241-56-unknown	RALRLD...	56	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P62241-63-unknown	GNFSWG...	63	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P62241-84-	NASNNE...	84		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P62241-89-unknown	ELVRTK...	89	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14247
P62241-125-unknown	KGAKLT...	125	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10126
P62241-126-	GAKLTP...	126		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62241-126-	GAKLTP...	126		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P62241-133-unknown	EEEILN...	133	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11763
P62241-187-unknown	GYVLEG...	187	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19254
P62241-187-unknown	GYVLEG...	187	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17782

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KRKYEL	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7635
...NASNNE	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14247
...PLGRKK	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10126
...KLTPEE	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11763
...CGRADG	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19254
...CGRADG	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17782
...ARKGK	208	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	28	KYEL.\|.LGRP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	88	SNNE.\|.ELVR	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	124	GRKK.\|.KGAK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	132	TPEE.\|.EEEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	186	RADG.\|.GYVL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	186	RADG.\|.GYVL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)