P40926: Malate dehydrogenase, mitochondrial

General Information

Protein names	- Malate dehydrogenase, mitochondrial - 1.1.1.37 {ECO:0000269\|PubMed:27989324}
Gene names	MDH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P40926

10 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSALARPAS AALRRSFSTS AQNNAKVAVL GASGGIGQPL SLLLKNSPLV SRLTLYDIAH
        70         80         90        100        110        120
TPGVAADLSH IETKAAVKGY LGPEQLPDCL KGCDVVVIPA GVPRKPGMTR DDLFNTNATI
       130        140        150        160        170        180
VATLTAACAQ HCPEAMICVI ANPVNSTIPI TAEVFKKHGV YNPNKIFGVT TLDIVRANTF
       190        200        210        220        230        240
VAELKGLDPA RVNVPVIGGH AGKTIIPLIS QCTPKVDFPQ DQLTALTGRI QEAGTEVVKA
       250        260        270        280        290        300
KAGAGSATLS MAYAGARFVF SLVDAMNGKE GVVECSFVKS QETECTYFST PLLLGKKGIE
       310        320        330
KNLGIGKVSS FEEKMISDAI PELKASIKKG EDFVKTLK

Isoforms

- Isoform 2 of Malate dehydrogenase, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P40926-18-	STSAQN...	18		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P40926-18-	STSAQN...	18		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P40926-25-unknown	AKVAVL...	25	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P40926-25-unknown	AKVAVL...	25	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P40926-25-	AKVAVL...	25		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P40926-25-	AKVAVL...	25		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P40926-25-	AKVAVL...	25		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P40926-25-	AKVAVL...	25		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P40926-25-	AKVAVL...	25		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P40926-31-unknown	GASGGI...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3796
P40926-82-unknown	GPEQLP...	82	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17637
P40926-94-unknown	DVVVIP...	94	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19098
P40926-95-unknown	VVVIPA...	95	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17638
P40926-108-unknown	MTRDDL...	108	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000461218
P40926-108-unknown	MTRDDL...	108	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416929
P40926-146-	STIPIT...	146		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P40926-146-	STIPIT...	146		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P40926-146-	STIPIT...	146		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P40926-146-	STIPIT...	146		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P40926-194-unknown	VPVIGG...	194	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17639

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVAVLG	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3796
...VKGYLG	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17637
...CLKGCD	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19098
...LKGCDV	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17638
...PARVNV	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17639
...VKTLK	338	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	30	AVLG.\|.GASG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	81	GYLG.\|.GPEQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	93	KGCD.\|.DVVV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	94	GCDV.\|.VVVI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	193	RVNV.\|.VPVI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)