O75083: WD repeat-containing protein 1

General Information

Protein names	- WD repeat-containing protein 1 - Actin-interacting protein 1 - AIP1 - NORI-1
Gene names	WDR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75083

7 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL ADIYTEHAHQ
        70         80         90        100        110        120
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV
       130        140        150        160        170        180
GEGREKFGAV FLWDSGSSVG EITGHNKVIN SVDIKQSRPY RLATGSDDNC AAFFEGPPFK
       190        200        210        220        230        240
FKFTIGDHSR FVNCVRFSPD GNRFATASAD GQIYIYDGKT GEKVCALGGS KAHDGGIYAI
       250        260        270        280        290        300
SWSPDSTHLL SASGDKTSKI WDVSVNSVVS TFPMGSTVLD QQLGCLWQKD HLLSVSLSGY
       310        320        330        340        350        360
INYLDRNNPS KPLHVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD SETGENDSFA
       370        380        390        400        410        420
GKGHTNQVSR MTVDESGQLI SCSMDDTVRY TSLMLRDYSG QGVVKLDVQP KCVAVGPGGY
       430        440        450        460        470        480
AVVVCIGQIV LLKDQRKCFS IDNPGYEPEV VAVHPGGDTV AIGGVDGNVR LYSILGTTLK
       490        500        510        520        530        540
DEGKLLEAKG PVTDVAYSHD GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW
       550        560        570        580        590        600
SPDNEHFASG GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY

Isoforms

- Isoform 2 of WD repeat-containing protein 1

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75083-1-unknown	MPYEIK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94414
O75083-1-unknown	MPYEIK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75083-2-unknown	PYEIKK...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75083-2-unknown	PYEIKK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75083-2-unknown	PYEIKK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75083-2-unknown	PYEIKK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111199
O75083-135-unknown	SGSSVG...	135	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5221
O75083-357-unknown	DSFAGK...	357	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16940
O75083-357-unknown	DSFAGK...	357	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18295
O75083-357-unknown	DSFAGK...	357	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147212
O75083-358-unknown	SFAGKG...	358	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178352
O75083-358-	SFAGKG...	358		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75083-474-unknown	ILGTTL...	474	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3288
O75083-474-unknown	ILGTTL...	474	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150606

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VFLWDS	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5221
...ETGEND	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16940
...ETGEND	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18295
...ETGEND	356	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130552
...VRLYSI	473	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3288
...VRLYSI	473	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134004
...WTITY	606	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WTITY	606	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90032

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	134	LWDS.\|.SGSS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	356	GEND.\|.DSFA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	356	GEND.\|.DSFA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	473	LYSI.\|.ILGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)