P06732: Creatine kinase M-type

General Information

Protein names	- Creatine kinase M-type - 2.7.3.2 - Creatine kinase M chain - Creatine phosphokinase M-type {ECO:0000305} - CPK-M - M-CK
Gene names	CKM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06732

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPFGNTHNKF KLNYKPEEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG FTVDDVIQTG
        70         80         90        100        110        120
VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY KPTDKHKTDL NHENLKGGDD
       130        140        150        160        170        180
LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT
       190        200        210        220        230        240
EKEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM
       250        260        270        280        290        300
EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA
       310        320        330        340        350        360
HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV QLVVDGVKLM
       370        380
VEMEKKLEKG QSIDDMIPAQ K

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06732-1-unknown	MPFGNT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06732-2-unknown	PFGNTH...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06732-2-unknown	PFGNTH...	2	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P06732-178-	SMTEKE...	178		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06732-195-unknown	DKPVSP...	195	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18522

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...DHFLFD	194	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18522
	...IPAQK	381	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	194	FLFD.\|.DKPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)