P23526: Adenosylhomocysteinase

General Information

Protein names	- Adenosylhomocysteinase - AdoHcyase - 3.3.1.1 - S-adenosyl-L-homocysteine hydrolase
Gene names	AHCY
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23526

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMRERYS ASKPLKGARI AGCLHMTVET
        70         80         90        100        110        120
AVLIETLVTL GAEVQWSSCN IFSTQDHAAA AIAKAGIPVY AWKGETDEEY LWCIEQTLYF
       130        140        150        160        170        180
KDGPLNMILD DGGDLTNLIH TKYPQLLPGI RGISEETTTG VHNLYKMMAN GILKVPAINV
       190        200        210        220        230        240
NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG YGDVGKGCAQ ALRGFGARVI
       250        260        270        280        290        300
ITEIDPINAL QAAMEGYEVT TMDEACQEGN IFVTTTGCID IILGRHFEQM KDDAIVCNIG
       310        320        330        340        350        360
HFDVEIDVKW LNENAVEKVN IKPQVDRYRL KNGRRIILLA EGRLVNLGCA MGHPSFVMSN
       370        380        390        400        410        420
SFTNQVMAQI ELWTHPDKYP VGVHFLPKKL DEAVAEAHLG KLNVKLTKLT EKQAQYLGMS
       430
CDGPFKPDHY RY

Isoforms

- Isoform 2 of Adenosylhomocysteinase

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P23526-2-unknown	MSDKLP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23526-2-Acetylation	SDKLPY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23526-2-Acetylation	SDKLPY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P23526-2-Acetylation	SDKLPY...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P23526-20-acetylation	KALDIA...	20	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P23526-29-unknown	MPGLMR...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88845
P23526-155-unknown	EETTTG...	155		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18938
P23526-155-unknown	EETTTG...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143794
P23526-157-acetylation	TTTGVH...	157	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P23526-157-acetylation	TTTGVH...	157	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182556
P23526-315-	AVEKVN...	315			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P23526-315-unknown	AVEKVN...	315		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172832
P23526-419-unknown	MSCDGP...	419		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3721
P23526-419-unknown	MSCDGP...	419		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151855

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IRGISE	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18938
...IRGISE	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127036
...AQYLGM	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3721
...AQYLGM	418	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135261
...DHYRY	432	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DHYRY	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84463

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	154	GISE.\|.EETT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	418	YLGM.\|.MSCD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)