P07737: Profilin-1

General Information

Protein names	- Profilin-1 - Epididymis tissue protein Li 184a - Profilin I
Gene names	PFN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07737

21 N-termini

11 C-termini

13 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY
        70         80         90        100        110        120
VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH
       130        140
GGLINKKCYE MASHLRRSQY

Isoforms

Sequence View

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Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

21 N-termini - 11 C-termini - 13 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07737-2-unknown	MAGWNA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07737-2-Acetylation	AGWNAY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07737-2-Acetylation	AGWNAY...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P07737-6-	AYIDNL...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-12-	MADGTC...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-13-unknown	ADGTCQ...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7220
P07737-15-	GTCQDA...	15			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-20-	AAIVGY...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-24-	GYKDSP...	24			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-33-	AAVPGK...	33			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P07737-33-unknown	AAVPGK...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8414
P07737-34-unknown	AVPGKT...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18559
P07737-41-unknown	VNITPA...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17178
P07737-41-unknown	VNITPA...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18560
P07737-42-	NITPAE...	42			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-42-	NITPAE...	42			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P07737-42-	NITPAE...	42			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P07737-43-unknown	ITPAEV...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17179
P07737-43-unknown	ITPAEV...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5447
P07737-43-unknown	ITPAEV...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18561
P07737-43-unknown	ITPAEV...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3516
P07737-47-unknown	EVGVLV...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17180
P07737-72-	SVIRDS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-80-unknown	QDGEFS...	80		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7221
P07737-82-	GEFSMD...	82			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P07737-92-	STGGAP...	92			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P07737-92-	STGGAP...	92			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P07737-92-	STGGAP...	92			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P07737-95-unknown	GAPTFN...	95		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7222
P07737-99-unknown	FNVTVT...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3517

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IDNLMA	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7220
...SPSVWA	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8414
...PSVWAA	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18559
...PGKTFV	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17178
...PGKTFV	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18560
...KTFVNI	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17179
...KTFVNI	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5447
...KTFVNI	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18561
...KTFVNI	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3516
...NITPAE	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17180
...RDSLLQ	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7221
...GEFSMD	86	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460363
...TKSTGG	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7222
...GGAPTF	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3517
...RRSQY	140	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	12	NLMA.\|.ADGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CMA1_HUMAN	32	SVWA.\|.AAVP	inferred from experiment	unknown	MEROPS	Caughey GH	Raymond WW et al.:Albumin is a substrate of human... (S01.140)	12815038,
MEP1B_HUMAN	33	VWAA.\|.AVPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	40	KTFV.\|.VNIT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	40	KTFV.\|.VNIT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	42	FVNI.\|.ITPA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	42	FVNI.\|.ITPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	42	FVNI.\|.ITPA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	42	FVNI.\|.ITPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	46	TPAE.\|.EVGV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	79	SLLQ.\|.QDGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	94	STGG.\|.GAPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	98	APTF.\|.FNVT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)