Q13200: 26S proteasome non-ATPase regulatory subunit 2

General Information

Protein names	- 26S proteasome non-ATPase regulatory subunit 2 - 26S proteasome regulatory subunit RPN1 - 26S proteasome regulatory subunit S2 - 26S proteasome subunit p97 - Protein 55.11 - Tumor necrosis factor type 1 receptor-associated protein 2
Gene names	PSMD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13200

7 N-termini

9 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 26S proteasome non-ATPase regulatory subunit 2 - Isoform 3 of 26S proteasome non-ATPase regulatory subunit 2

Sequence View

        10         20         30         40         50         60
MEEGGRDKAP VQPQQSPAAA PGGTDEKPSG KERRDAGDKD KEQELSEEDK QLQDELEMLV
        70         80         90        100        110        120
ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR PHYGKLKEIY ENMAPGENKR
       130        140        150        160        170        180
FAADIISVLA MTMSGERECL KYRLVGSQEE LASWGHEYVR HLAGEVAKEW QELDDAEKVQ
       190        200        210        220        230        240
REPLLTLVKE IVPYNMAHNA EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV
       250        260        270        280        290        300
PEPENSALLR CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
       310        320        330        340        350        360
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK THLENNRFGG
       370        380        390        400        410        420
SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY KNKDHGMLSA AASLGMILLW
       430        440        450        460        470        480
DVDGGLTQID KYLYSSEDYI KSGALLACGI VNSGVRNECD PALALLSDYV LHNSNTMRLG
       490        500        510        520        530        540
SIFGLGLAYA GSNREDVLTL LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ
       550        560        570        580        590        600
TIMEKSETEL KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
       610        620        630        640        650        660
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ GVAVLGIALI
       670        680        690        700        710        720
AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS NPRLNILDTL SKFSHDADPE
       730        740        750        760        770        780
VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP
       790        800        810        820        830        840
YHSDRQLMSQ VAVAGLLTVL VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL
       850        860        870        880        890        900
PVSVRVGQAV DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL

RKNPNYDL         10         20         30         40         50         60
MEEGGRDKAP VQPQQSPAAA PGGTDEKPSG KERRDAGDKD KEQELSEEDK QLQDELEMLV
        70         80         90        100        110        120
ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR PHYGKLKEIY ENMAPGENKR
       130        140        150        160        170        180
FAADIISVLA MTMSGERECL KYRLVGSQEE LASWGHEYVR HLAGEVAKEW QELDDAEKVQ
       190        200        210        220        230        240
REPLLTLVKE IVPYNMAHNA EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV
       250        260        270        280        290        300
PEPENSALLR CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
       310        320        330        340        350        360
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK THLENNRFGG
       370        380        390        400        410        420
SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY KNKDHGMLSA AASLGMILLW
       430        440        450        460        470        480
DVDGGLTQID KYLYSSEDYI KSGALLACGI VNSGVRNECD PALALLSDYV LHNSNTMRLG
       490        500        510        520        530        540
SIFGLGLAYA GSNREDVLTL LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ
       550        560        570        580        590        600
TIMEKSETEL KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
       610        620        630        640        650        660
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ GVAVLGIALI
       670        680        690        700        710        720
AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS NPRLNILDTL SKFSHDADPE
       730        740        750        760        770        780
VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP
       790        800        810        820        830        840
YHSDRQLMSQ VAVAGLLTVL VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL
       850        860        870        880        890        900
PVSVRVGQAV DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL

RKNPNYDL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 9 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q13200-1-Acetylation	MEEGGR...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13200-16-unknown	SPAAAP...	16		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7760
Q13200-19-unknown	AAPGGT...	19		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7761
Q13200-20-unknown	APGGTD...	20		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19410
Q13200-20-unknown	APGGTD...	20		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17886
Q13200-131-unknown	MTMSGE...	131		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416028
Q13200-342-unknown	PKVPDD...	342		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3979
Q13200-852-unknown	VVGQAG...	852		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3980

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VQPQQS	15	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7760
...QQSPAA	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7761
...QSPAAA	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19410
...QSPAAA	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17886
...VVVQKQ	292	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000414061
...LDIMEP	341	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3979
...QGLTHL	770	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400330
...GQAVDV	851	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3980
...PNYDL	908	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...PNYDL	908		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PNYDL	908		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...PNYDL	908		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PNYDL	908		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	15	PQQS.\|.SPAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	18	SPAA.\|.AAPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	19	PAAA.\|.APGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	19	PAAA.\|.APGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	341	IMEP.\|.PKVP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	851	AVDV.\|.VVGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)