Q04695: Keratin, type I cytoskeletal 17

General Information

Protein names	- Keratin, type I cytoskeletal 17 - 39.1 - Cytokeratin-17 - CK-17 - Keratin-17 - K17
Gene names	KRT17
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q04695

9 N-termini

10 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS TLGGSSYSSC
        70         80         90        100        110        120
YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY
       130        140        150        160        170        180
QRQAPGPARD YSQYYRTIEE LQNKILTATV DNANILLQID NARLAADDFR TKFETEQALR
       190        200        210        220        230        240
LSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE
       250        260        270        280        290        300
MDAAPGVDLS RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI
       310        320        330        340        350        360
SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM
       370        380        390        400        410        420
EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK EPVTTRQVRT IVEEVQDGKV
       430
ISSREQVHQT TR

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 10 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q04695-1-unknown	MTTSIR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q04695-16-unknown	GSSGLG...	16	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467418
Q04695-206-unknown	MQIENL...	206	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468672
Q04695-243-unknown	AAPGVD...	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2693
Q04695-258-unknown	DQYEKM...	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19345
Q04695-272-unknown	EDWFFS...	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19346
Q04695-273-unknown	DWFFSK...	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19347
Q04695-273-unknown	DWFFSK...	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17850
Q04695-414-unknown	EVQDGK...	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19348
Q04695-414-unknown	EVQDGK...	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17851
Q04695-418-unknown	GKVISS...	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2928

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NVEMDA	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2693
...RILNEM	255	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466166
...LNEMRD	257	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19345
...KMAEKN	266	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467418
...NRKDAE	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19346
...RKDAED	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19347
...RKDAED	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17850
...GKSEIS	300	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468672
...RTIVEE	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19348
...RTIVEE	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17851
...EEVQDG	417	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2928
...HQTTR	432	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	242	EMDA.\|.AAPG	inferred from experiment	unknown	MEROPS	Otto A	Badock V et al.:Apoptosis-induced cleavage of k... (C14.003)	11319614,
MEP1B_HUMAN	257	EMRD.\|.DQYE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	271	KDAE.\|.EDWF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	272	DAED.\|.DWFF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	272	DAED.\|.DWFF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	413	IVEE.\|.EVQD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	413	IVEE.\|.EVQD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP7_HUMAN	417	VQDG.\|.GKVI	inferred from experiment	unknown	MEROPS	Otto A	Badock V et al.:Apoptosis-induced cleavage of k... (C14.003)	11319614,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)