O60437: Periplakin

General Information

Protein names	- Periplakin - 190 kDa paraneoplastic pemphigus antigen - 195 kDa cornified envelope precursor protein
Gene names	PPL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60437

8 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNSLFRKRNK GKYSPTVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA KMQSDLARLQ
        70         80         90        100        110        120
EGRQPEHRDV TLQKVLDSEK LLYVLEADAA IAKHMKHPQG DMIAEDIRQL KERVTNLRGK
       130        140        150        160        170        180
HKQIYRLAVK EVDPQVNWAA LVEEKLDKLN NQSFGTDLPL VDHQVEEHNI FHNEVKAIGP
       190        200        210        220        230        240
HLAKDGDKEQ NSELRAKYQK LLAASQARQQ HLSSLQDYMQ RCTNELYWLD QQAKGRMQYD
       250        260        270        280        290        300
WSDRNLDYPS RRRQYENFIN RNLEAKEERI NKLHSEGDQL LAAEHPGRNS IEAHMEAVHA
       310        320        330        340        350        360
DWKEYLNLLI CEESHLKYME DYHQFHEDVK DAQELLRKVD SDLNQKYGPD FKDRYQIELL
       370        380        390        400        410        420
LRELDDQEKV LDKYEDVVQG LQKRGQQVVP LKYRRETPLK PIPVEALCDF EGEQGLISRG
       430        440        450        460        470        480
YSYTLQKNNG ESWELMDSAG NKLIAPAVCF VIPPTDPEAL ALADSLGSQY RSVRQKAAGS
       490        500        510        520        530        540
KRTLQQRYEV LKTENPGDAS DLQGRQLLAG LDKVASDLDR QEKAITGILR PPLEQGRAVQ
       550        560        570        580        590        600
DSAERAKDLK NITNELLRIE PEKTRSTAEG EAFIQALPGS GTTPLLRTRV EDTNRKYEHL
       610        620        630        640        650        660
LQLLDLAQEK VDVANRLEKS LQQSWELLAT HENHLNQDDT VPESSRVLDS KGQELAAMAC
       670        680        690        700        710        720
ELQAQKSLLG EVEQNLQAAK QCSSTLASRF QEHCPDLERQ EAEVHKLGQR FNNLRQQVER
       730        740        750        760        770        780
RAQSLQSAKA AYEHFHRGHD HVLQFLVSIP SYEPQETDSL SQMETKLKNQ KNLLDEIASR
       790        800        810        820        830        840
EQEVQKICAN SQQYQQAVKD YELEAEKLRS LLDLENGRRS HVSKRARLQS PATKVKEEEA
       850        860        870        880        890        900
ALAAKFTEVY AINRQRLQNL EFALNLLRQQ PEVEVTHETL QRNRPDSGVE EAWKIRKELD
       910        920        930        940        950        960
EETERRRQLE NEVKSTQEEI WTLRNQGPQE SVVRKEVLKK VPDPVLEESF QQLQRTLAEE
       970        980        990       1000       1010       1020
QHKNQLLQEE LEALQLQLRA LEQETRDGGQ EYVVKEVLRI EPDRAQADEV LQLREELEAL
      1030       1040       1050       1060       1070       1080
RRQKGAREAE VLLLQQRVAA LAEEKSRAQE KVTEKEVVKL QNDPQLEAEY QQLQEDHQRQ
      1090       1100       1110       1120       1130       1140
DQLREKQEEE LSFLQDKLKR LEKERAMAEG KITVKEVLKV EKDAATEREV SDLTRQYEDE
      1150       1160       1170       1180       1190       1200
AAKARASQRE KTELLRKIWA LEEENAKVVV QEKVREIVRP DPKAESEVAN LRLELVEQER
      1210       1220       1230       1240       1250       1260
KYRGAEEQLR SYQSELEALR RRGPQVEVKE VTKEVIKYKT DPEMEKELQR LREEIVDKTR
      1270       1280       1290       1300       1310       1320
LIERCDLEIY QLKKEIQALK DTKPQVQTKE VVQEILQFQE DPQTKEEVAS LRAKLSEEQK
      1330       1340       1350       1360       1370       1380
KQVDLERERA SQEEQIARKE EELSRVKERV VQQEVVRYEE EPGLRAEASA FAESIDVELR
      1390       1400       1410       1420       1430       1440
QIDKLRAELR RLQRRRTELE RQLEELERER QARREAEREV QRLQQRLAAL EQEEAEAREK
      1450       1460       1470       1480       1490       1500
VTHTQKVVLQ QDPQQAREHA LLRLQLEEEQ HRRQLLEGEL ETLRRKLAAL EKAEVKEKVV
      1510       1520       1530       1540       1550       1560
LSESVQVEKG DTEQEIQRLK SSLEEESRSK RELDVEVSRL EARLSELEFH NSKSSKELDF
      1570       1580       1590       1600       1610       1620
LREENHKLQL ERQNLQLETR RLQSEINMAA TETRDLRNMT VADSGTNHDS RLWSLERELD
      1630       1640       1650       1660       1670       1680
DLKRLSKDKD LEIDELQKRL GSVAVKREQR ENHLRRSIVV IHPDTGRELS PEEAHRAGLI
      1690       1700       1710       1720       1730       1740
DWNMFVKLRS QECDWEEISV KGPNGESSVI HDRKSGKKFS IEEALQSGRL TPAQYDRYVN
      1750
KDMSIQELAV LVSGQK

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O60437-1-unknown	MNSLFR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O60437-52-unknown	MQSDLA...	52	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467699
O60437-800-unknown	DYELEA...	800	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16930
O60437-800-unknown	DYELEA...	800	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18271
O60437-987-unknown	DGGQEY...	987	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16931
O60437-987-unknown	DGGQEY...	987	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18272
O60437-1162-unknown	EEENAK...	1162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18273
O60437-1163-unknown	EENAKV...	1163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16932
O60437-1163-unknown	EENAKV...	1163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18274
O60437-1604-unknown	SGTNHD...	1604	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2421
O60437-1630-unknown	DLEIDE...	1630	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18275

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QQAVKD	799	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16930
...QQAVKD	799	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18271
...EQETRD	986	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16931
...EQETRD	986	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18272
...KIWALE	1161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18273
...IWALEE	1162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16932
...IWALEE	1162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18274
...MTVADS	1603	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2421
...LSKDKD	1629	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18275
...SQECDW	1694	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467699
...VSGQK	1756	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	799	AVKD.\|.DYEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	799	AVKD.\|.DYEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	986	ETRD.\|.DGGQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	986	ETRD.\|.DGGQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	1161	WALE.\|.EEEN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	1162	ALEE.\|.EENA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	1162	ALEE.\|.EENA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP6_HUMAN	1603	VADS.\|.SGTN	inferred from experiment	unknown	MEROPS	Aho S	Kalinin AE et al.:Breaking the connection: caspas... (C14.005)	15654952,
MEP1B_HUMAN	1629	KDKD.\|.DLEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)