P35637: RNA-binding protein FUS

General Information

Protein names	- RNA-binding protein FUS - 75 kDa DNA-pairing protein - Oncogene FUS - Oncogene TLS - POMp75 - Translocated in liposarcoma protein
Gene names	FUS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35637

30 N-termini

7 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ
        70         80         90        100        110        120
SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY GQQPAPSSTS GSYGSSSQSS
       130        140        150        160        170        180
SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD
       190        200        210        220        230        240
QSSMSSGGGS GGGYGNQDQS GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE
       250        260        270        280        290        300
PRGRGGGRGG RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES
       310        320        330        340        350        360
VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA IDWFDGKEFS
       370        380        390        400        410        420
GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG GSGGGGRGGF PSGGGGGGGQ
       430        440        450        460        470        480
QRAGDWKCPN PTCENMNFSW RNECNQCKAP KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD
       490        500        510        520
RGGYRGRGGD RGGFRGGRGG GDRGGFGPGK MDSRGEHRQD RRERPY

Isoforms

- Isoform Short of RNA-binding protein FUS

Sequence View

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Protein Neighborhood

Domains & Features

30 N-termini - 7 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P35637-1-unknown	MASNDY...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35637-1-unknown	MASNDY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75541
P35637-63-unknown	NTGYGT...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3781
P35637-97-unknown	YPGYGQ...	97	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3782
P35637-97-unknown	YPGYGQ...	97	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142213
P35637-183-unknown	SMSSGG...	183	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169500
P35637-183-	SMSSGG...	183		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P35637-183-	SMSSGG...	183		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35637-185-	SSGGGS...	185		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P35637-185-unknown	SSGGGS...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14093
P35637-185-unknown	SSGGGS...	185	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146019
P35637-196-unknown	NQDQSG...	196	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5818
P35637-196-unknown	NQDQSG...	196	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146439
P35637-197-	QDQSGG...	197		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35637-197-unknown	QDQSGG...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172133
P35637-199-unknown	QSGGGG...	199	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173291
P35637-199-	QSGGGG...	199		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35637-316-unknown	KTGQPM...	316	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169503
P35637-316-	KTGQPM...	316		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P35637-316-	KTGQPM...	316		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P35637-335-	GEATVS...	335		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35637-335-unknown	GEATVS...	335	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172135
P35637-356-unknown	GKEFSG...	356		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P35637-356-unknown	GKEFSG...	356	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161580
P35637-356-	GKEFSG...	356		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P35637-356-	GKEFSG...	356		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P35637-356-	GKEFSG...	356		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P35637-356-	GKEFSG...	356		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P35637-356-	GKEFSG...	356		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P35637-356-	GKEFSG...	356		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P35637-356-	GKEFSG...	356		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P35637-358-	EFSGNP...	358		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P35637-358-unknown	EFSGNP...	358	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177282
P35637-359-	FSGNPI...	359		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P35637-359-unknown	FSGNPI...	359	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175017
P35637-361-unknown	GNPIKV...	361	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5820
P35637-361-unknown	GNPIKV...	361	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151178
P35637-425-unknown	DWKCPN...	425	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19078
P35637-425-unknown	DWKCPN...	425	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17618
P35637-425-unknown	DWKCPN...	425	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152399
P35637-449-	APKPDG...	449		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P35637-449-unknown	APKPDG...	449	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169498
P35637-456-unknown	GGGPGG...	456	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175013
P35637-456-	GGGPGG...	456		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P35637-457-unknown	GGPGGS...	457	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175015
P35637-457-	GGPGGS...	457		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YGQSQN	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3781
...YGQSQN	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153943
...GQQSSY	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3782
...GQQSSY	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125401
...DQSSMS	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14093
...DQSSMS	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129318
...GGGYGN	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5818
...GGGYGN	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129744
...GKEFSG	360	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5820
...GKEFSG	360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134580
...QQRAGD	424	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19078
...QQRAGD	424	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17618
...QQRAGD	424	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135810
...RERPY	526	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RERPY	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71159

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	62	QSQN.\|.NTGY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	96	QSSY.\|.YPGY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	184	SSMS.\|.SSGG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	195	GYGN.\|.NQDQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	360	EFSG.\|.GNPI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	424	RAGD.\|.DWKC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	424	RAGD.\|.DWKC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)