Q13442: 28 kDa heat- and acid-stable phosphoprotein

General Information

Protein names	- 28 kDa heat- and acid-stable phosphoprotein - PDGF-associated protein - PAP - PDGFA-associated protein 1 - PAP1
Gene names	PDAP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13442

16 N-termini

9 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKGGRKGGH KGRARQYTSP EEIDAQLQAE KQKAREEEEQ KEGGDGAAGD PKKEKKSLDS
        70         80         90        100        110        120
DESEDEEDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD LDGPKELSRR EREEIEKQKA
       130        140        150        160        170        180
KERYMKMHLA GKTEQAKADL ARLAIIRKQR EEAARKKEEE RKAKDDATLS GKRMQSLSLN

K

Isoforms

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

16 N-termini - 9 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13442-1-unknown	MPKGGR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13442-18-unknown	TSPEEI...	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17903
Q13442-18-unknown	TSPEEI...	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19442
Q13442-19-unknown	SPEEID...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17904
Q13442-19-unknown	SPEEID...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19443
Q13442-25-unknown	AQLQAE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2183
Q13442-25-	AQLQAE...	25		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13442-56-	KSLDSD...	56		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13442-57-unknown	SLDSDE...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14434
Q13442-59-unknown	DSDESE...	59	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14435
Q13442-62-unknown	ESEDEE...	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12083
Q13442-75-	KGVEGL...	75		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13442-95-unknown	KVTQLD...	95		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13442-95-	KVTQLD...	95		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13442-127-	MHLAGK...	127		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13442-127-unknown	MHLAGK...	127		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13442-128-	HLAGKT...	128		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13442-130-unknown	AGKTEQ...	130	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14436
Q13442-130-unknown	AGKTEQ...	130	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17905

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RARQYT	17	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17903
...RARQYT	17	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19442
...ARQYTS	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17904
...ARQYTS	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19443
...PEEIDA	24	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2183
...KKEKKS	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14434
...EKKSLD	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14435
...SLDSDE	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12083
...MKMHLA	129	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14436
...MKMHLA	129	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17905
...LSLNK	181	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LSLNK	181		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LSLNK	181		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LSLNK	181		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LSLNK	181		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	17	RQYT.\|.TSPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	17	RQYT.\|.TSPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	18	QYTS.\|.SPEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	18	QYTS.\|.SPEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	24	EIDA.\|.AQLQ	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> HAP28_HUMAN @24
GRAM_HUMAN	56	EKKS.\|.SLDS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	58	KSLD.\|.DSDE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	61	DSDE.\|.ESED	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	129	MHLA.\|.AGKT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	129	MHLA.\|.AGKT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)