P15692: Vascular endothelial growth factor A

General Information

Protein names	- Vascular endothelial growth factor A - VEGF-A - Vascular permeability factor - VPF
Gene names	VEGFA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P15692

4 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform VEGF189 of Vascular endothelial growth factor A - Isoform VEGF183 of Vascular endothelial growth factor A - Isoform VEGF165 of Vascular endothelial growth factor A - Isoform VEGF148 of Vascular endothelial growth factor A - Isoform VEGF145 of Vascular endothelial growth factor A - Isoform VEGF165B of Vascular endothelial growth factor A - Isoform VEGF121 of Vascular endothelial growth factor A - Isoform VEGF111 of Vascular endothelial growth factor A - Isoform L-VEGF165 of Vascular endothelial growth factor A - Isoform L-VEGF121 of Vascular endothelial growth factor A - Isoform L-VEGF189 of Vascular endothelial growth factor A - Isoform L-VEGF206 of Vascular endothelial growth factor A - Isoform 15 of Vascular endothelial growth factor A - Isoform 16 of Vascular endothelial growth factor A - Isoform 17 of Vascular endothelial growth factor A - Isoform 18 of Vascular endothelial growth factor A

Sequence View

        10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR         10         20         30         40         50         60
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD
        70         80         90        100        110        120
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM
       130        140        150        160        170        180
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG
       190        200        210        220        230
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P15692-1-unknown	MNFLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94090
P15692-1-unknown	MNFLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94091
P15692-1-unknown	MNFLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94092
P15692-1-unknown	MNFLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94093
P15692-1-unknown	MNFLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94094
P15692-1-unknown	MNFLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94095
P15692-1-unknown	MNFLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94096
P15692-27-unknown	APMAEG...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P15692-27-unknown	APMAEG...	27	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429592
P15692-27-unknown	APMAEG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114196
P15692-27-unknown	APMAEG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114197
P15692-27-unknown	APMAEG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114198
P15692-27-unknown	APMAEG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114199
P15692-27-unknown	APMAEG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114200
P15692-27-unknown	APMAEG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114201
P15692-27-unknown	APMAEG...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114202
P15692-29-unknown	MAEGGG...	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000230480
P15692-29-unknown	MAEGGG...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129162
P15692-29-unknown	MAEGGG...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129163
P15692-29-unknown	MAEGGG...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129164
P15692-29-unknown	MAEGGG...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129165
P15692-29-unknown	MAEGGG...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129166
P15692-29-unknown	MAEGGG...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129167
P15692-29-unknown	MAEGGG...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt129168
P15692-31-unknown	EGGGQN...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18764
P15692-31-unknown	EGGGQN...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17369
P15692-31-unknown	EGGGQN...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137605
P15692-31-unknown	EGGGQN...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137606
P15692-31-unknown	EGGGQN...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137607
P15692-31-unknown	EGGGQN...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137609
P15692-31-unknown	EGGGQN...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137611
P15692-31-unknown	EGGGQN...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137613
P15692-31-unknown	EGGGQN...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137614

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AAPMAE	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18764
...AAPMAE	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17369
...AAPMAE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120598
...AAPMAE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120599
...AAPMAE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120600
...AAPMAE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120602
...AAPMAE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120604
...AAPMAE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120606
...AAPMAE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120607
...DKPRR	232	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DKPRR	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89710
...DKPRR	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89709
...DKPRR	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89708

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	30	PMAE.\|.EGGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	30	PMAE.\|.EGGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)