Q86UP2: Kinectin

General Information

Protein names	- Kinectin - CG-1 antigen - Kinesin receptor
Gene names	KTN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86UP2

7 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Kinectin - Isoform 3 of Kinectin - Isoform 4 of Kinectin

Sequence View

        10         20         30         40         50         60
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK
        70         80         90        100        110        120
KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK
       130        140        150        160        170        180
QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK
       190        200        210        220        230        240
VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA
       250        260        270        280        290        300
DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE
       310        320        330        340        350        360
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ
       370        380        390        400        410        420
EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA
       430        440        450        460        470        480
HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE
       490        500        510        520        530        540
QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL
       550        560        570        580        590        600
VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV
       610        620        630        640        650        660
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE
       670        680        690        700        710        720
QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL
       730        740        750        760        770        780
VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ
       790        800        810        820        830        840
DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA
       850        860        870        880        890        900
LKEEIGNVQL EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL
       910        920        930        940        950        960
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK ERESDLSSKT
       970        980        990       1000       1010       1020
QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV ISEREKEISG LWNELDSLKD
      1030       1040       1050       1060       1070       1080
AVEHQRKKNN DLREKNWEAM EALASTEKML QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF
      1090       1100       1110       1120       1130       1140
PKVSVPSNLS YGEWLHGFEK KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK
      1150       1160       1170       1180       1190       1200
SVLAETEGIL QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE
      1210       1220       1230       1240       1250       1260
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR QNEELNLLKA
      1270       1280       1290       1300       1310       1320
QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA AGDTTVIENS DVSPETESSE
      1330       1340       1350
KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK EHYQVLE         10         20         30         40         50         60
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK
        70         80         90        100        110        120
KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK
       130        140        150        160        170        180
QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK
       190        200        210        220        230        240
VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA
       250        260        270        280        290        300
DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE
       310        320        330        340        350        360
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ
       370        380        390        400        410        420
EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA
       430        440        450        460        470        480
HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE
       490        500        510        520        530        540
QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL
       550        560        570        580        590        600
VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV
       610        620        630        640        650        660
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE
       670        680        690        700        710        720
QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL
       730        740        750        760        770        780
VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ
       790        800        810        820        830        840
DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA
       850        860        870        880        890        900
LKEEIGNVQL EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL
       910        920        930        940        950        960
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK ERESDLSSKT
       970        980        990       1000       1010       1020
QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV ISEREKEISG LWNELDSLKD
      1030       1040       1050       1060       1070       1080
AVEHQRKKNN DLREKNWEAM EALASTEKML QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF
      1090       1100       1110       1120       1130       1140
PKVSVPSNLS YGEWLHGFEK KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK
      1150       1160       1170       1180       1190       1200
SVLAETEGIL QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE
      1210       1220       1230       1240       1250       1260
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR QNEELNLLKA
      1270       1280       1290       1300       1310       1320
QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA AGDTTVIENS DVSPETESSE
      1330       1340       1350
KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK EHYQVLE         10         20         30         40         50         60
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK
        70         80         90        100        110        120
KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK
       130        140        150        160        170        180
QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK
       190        200        210        220        230        240
VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA
       250        260        270        280        290        300
DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE
       310        320        330        340        350        360
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ
       370        380        390        400        410        420
EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA
       430        440        450        460        470        480
HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE
       490        500        510        520        530        540
QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL
       550        560        570        580        590        600
VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV
       610        620        630        640        650        660
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE
       670        680        690        700        710        720
QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL
       730        740        750        760        770        780
VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ
       790        800        810        820        830        840
DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA
       850        860        870        880        890        900
LKEEIGNVQL EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL
       910        920        930        940        950        960
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK ERESDLSSKT
       970        980        990       1000       1010       1020
QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV ISEREKEISG LWNELDSLKD
      1030       1040       1050       1060       1070       1080
AVEHQRKKNN DLREKNWEAM EALASTEKML QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF
      1090       1100       1110       1120       1130       1140
PKVSVPSNLS YGEWLHGFEK KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK
      1150       1160       1170       1180       1190       1200
SVLAETEGIL QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE
      1210       1220       1230       1240       1250       1260
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR QNEELNLLKA
      1270       1280       1290       1300       1310       1320
QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA AGDTTVIENS DVSPETESSE
      1330       1340       1350
KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK EHYQVLE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86UP2-1-unknown	MEFYES...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86UP2-1-unknown	MEFYES...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79281
Q86UP2-1-unknown	MEFYES...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79282
Q86UP2-1-unknown	MEFYES...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79283
Q86UP2-103-	NVVETS...	103		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86UP2-103-unknown	NVVETS...	103	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169231
Q86UP2-103-unknown	NVVETS...	103	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169232
Q86UP2-103-unknown	NVVETS...	103	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169233
Q86UP2-176-unknown	DQDKKV...	176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18019
Q86UP2-176-unknown	DQDKKV...	176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19668
Q86UP2-176-unknown	DQDKKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145733
Q86UP2-176-unknown	DQDKKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145734
Q86UP2-176-unknown	DQDKKV...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145735
Q86UP2-237-	MDNADS...	237		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86UP2-237-unknown	MDNADS...	237		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86UP2-237-unknown	MDNADS...	237	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159862
Q86UP2-237-unknown	MDNADS...	237	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159863
Q86UP2-237-unknown	MDNADS...	237	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159864
Q86UP2-929-unknown	EELEIV...	929	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19672
Q86UP2-929-unknown	EELEIV...	929	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156929
Q86UP2-929-unknown	EELEIV...	929	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157005
Q86UP2-929-unknown	EELEIV...	929	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KNGSDD	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18019
...KNGSDD	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19668
...KNGSDD	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129030
...KNGSDD	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129031
...KNGSDD	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129032
...SASQFE	928	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19672
...SASQFE	928	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140417
...SASQFE	928	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140496
...SASQFE	928	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140497
...YQVLE	1357	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YQVLE	1357	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74899
...YQVLE	1357	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74900
...YQVLE	1357	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74901

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	175	GSDD.\|.DQDK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	175	GSDD.\|.DQDK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	928	SQFE.\|.EELE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)