Q00059: Transcription factor A, mitochondrial

General Information

Protein names	- Transcription factor A, mitochondrial - mtTFA - Mitochondrial transcription factor 1 - MtTF1 - Transcription factor 6 - TCF-6 - Transcription factor 6-like 2
Gene names	TFAM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q00059

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAFLRSMWGV LSALGRSGAE LCTGCGSRLR SPFSFVYLPR WFSSVLASCP KKPVSSYLRF
        70         80         90        100        110        120
SKEQLPIFKA QNPDAKTTEL IRRIAQRWRE LPDSKKKIYQ DAYRAEWQVY KEEISRFKEQ
       130        140        150        160        170        180
LTPSQIMSLE KEIMDKHLKR KAMTKKKELT LLGKPKRPRS AYNVYVAERF QEAKGDSPQE
       190        200        210        220        230        240
KLKTVKENWK NLSDSEKELY IQHAKEDETR YHNEMKSWEE QMIEVGRKDL LRRTIKKQRK

YGAEEC

Isoforms

- Isoform 2 of Transcription factor A, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00059-1-unknown	MAFLRS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91973
Q00059-42-	FSSVLA...	42		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00059-42-unknown	FSSVLA...	42	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172339
Q00059-43-unknown	SSVLAS...	43	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00059-43-unknown	SSVLAS...	43		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q00059-43-unknown	SSVLAS...	43	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115484
Q00059-43-	SSVLAS...	43		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00059-44-	SVLASC...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00059-44-	SVLASC...	44		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q00059-44-unknown	SVLASC...	44	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172336
Q00059-220-unknown	EQMIEV...	220	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19305
Q00059-220-unknown	EQMIEV...	220	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146176

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MKSWEE	219	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19305
...MKSWEE	219	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129479
...GAEEC	246	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GAEEC	246	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt87591
...GAEEC	246		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	219	SWEE.\|.EQMI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)