O14979: Heterogeneous nuclear ribonucleoprotein D-like

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein D-like - hnRNP D-like - hnRNP DL - AU-rich element RNA-binding factor - JKT41-binding protein - Protein laAUF1
Gene names	HNRNPDL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14979

18 N-termini

11 C-termini

15 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Heterogeneous nuclear ribonucleoprotein D-like - Isoform 3 of Heterogeneous nuclear ribonucleoprotein D-like

Sequence View

        10         20         30         40         50         60
MEVPPRLSHV PPPLFPSAPA TLASRSLSHW RPRPPRQLAP LLPSLAPSSA RQGARRAQRH
        70         80         90        100        110        120
VTAQQPSRLA GGAAIKGGRR RRPDLFRRHF KSSSIQRSAA AAAATRTARQ HPPADSSVTM
       130        140        150        160        170        180
EDMNEYSNIE EFAEGSKINA SKNQQDDGKM FIGGLSWDTS KKDLTEYLSR FGEVVDCTIK
       190        200        210        220        230        240
TDPVTGRSRG FGFVLFKDAA SVDKVLELKE HKLDGKLIDP KRAKALKGKE PPKKVFVGGL
       250        260        270        280        290        300
SPDTSEEQIK EYFGAFGEIE NIELPMDTKT NERRGFCFIT YTDEEPVKKL LESRYHQIGS
       310        320        330        340        350        360
GKCEIKVAQP KEVYRQQQQQ QKGGRGAAAG GRGGTRGRGR GQGQNWNQGF NNYYDQGYGN
       370        380        390        400        410        420
YNSAYGGDQN YSGYGGYDYT GYNYGNYGYG QGYADYSGQQ STYGKASRGG GNHQNNYQPY

        10         20         30         40         50         60
MEVPPRLSHV PPPLFPSAPA TLASRSLSHW RPRPPRQLAP LLPSLAPSSA RQGARRAQRH
        70         80         90        100        110        120
VTAQQPSRLA GGAAIKGGRR RRPDLFRRHF KSSSIQRSAA AAAATRTARQ HPPADSSVTM
       130        140        150        160        170        180
EDMNEYSNIE EFAEGSKINA SKNQQDDGKM FIGGLSWDTS KKDLTEYLSR FGEVVDCTIK
       190        200        210        220        230        240
TDPVTGRSRG FGFVLFKDAA SVDKVLELKE HKLDGKLIDP KRAKALKGKE PPKKVFVGGL
       250        260        270        280        290        300
SPDTSEEQIK EYFGAFGEIE NIELPMDTKT NERRGFCFIT YTDEEPVKKL LESRYHQIGS
       310        320        330        340        350        360
GKCEIKVAQP KEVYRQQQQQ QKGGRGAAAG GRGGTRGRGR GQGQNWNQGF NNYYDQGYGN
       370        380        390        400        410        420
YNSAYGGDQN YSGYGGYDYT GYNYGNYGYG QGYADYSGQQ STYGKASRGG GNHQNNYQPY

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 11 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14979-1-unknown	MEVPPR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14979-120-unknown	MEDMNE...	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77142
O14979-120-unknown	MEDMNE...	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77143
O14979-127-	SNIEEF...	127		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O14979-127-	SNIEEF...	127		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O14979-127-unknown	SNIEEF...	127		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14979-127-unknown	SNIEEF...	127	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159727
O14979-127-unknown	SNIEEF...	127	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159728
O14979-151-unknown	FIGGLS...	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3254
O14979-151-unknown	FIGGLS...	151	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137738
O14979-151-unknown	FIGGLS...	151	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137739
O14979-153-unknown	GGLSWD...	153	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7001
O14979-153-unknown	GGLSWD...	153	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137866
O14979-153-unknown	GGLSWD...	153	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137867
O14979-154-unknown	GLSWDT...	154	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5120
O14979-154-unknown	GLSWDT...	154	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7004
O14979-154-unknown	GLSWDT...	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137925
O14979-154-unknown	GLSWDT...	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137926
O14979-158-unknown	DTSKKD...	158	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18216
O14979-158-unknown	DTSKKD...	158	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16866
O14979-158-unknown	DTSKKD...	158	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138234
O14979-158-unknown	DTSKKD...	158	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138235
O14979-159-unknown	TSKKDL...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10689
O14979-159-unknown	TSKKDL...	159	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138367
O14979-159-unknown	TSKKDL...	159	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138368
O14979-239-unknown	GLSPDT...	239	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5123
O14979-239-unknown	GLSPDT...	239	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7007
O14979-239-unknown	GLSPDT...	239	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3257
O14979-239-unknown	GLSPDT...	239	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143449
O14979-239-unknown	GLSPDT...	239	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143450
O14979-244-unknown	TSEEQI...	244	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10692
O14979-244-unknown	TSEEQI...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143712
O14979-244-unknown	TSEEQI...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143713
O14979-257-	GEIENI...	257		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O14979-257-unknown	GEIENI...	257	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176989
O14979-257-unknown	GEIENI...	257	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176990
O14979-261-	NIELPM...	261		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14979-261-unknown	NIELPM...	261	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174112
O14979-261-unknown	NIELPM...	261	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174113
O14979-278-unknown	FITYTD...	278	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5126
O14979-278-unknown	FITYTD...	278	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3260
O14979-278-unknown	FITYTD...	278	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145085
O14979-278-unknown	FITYTD...	278	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145087
O14979-279-unknown	ITYTDE...	279	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5129
O14979-279-unknown	ITYTDE...	279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145120
O14979-279-unknown	ITYTDE...	279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145121
O14979-280-unknown	TYTDEE...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5132
O14979-280-unknown	TYTDEE...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145171
O14979-280-unknown	TYTDEE...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145172

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDGKMF	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3254
...DDGKMF	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120737
...DDGKMF	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120738
...GKMFIG	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7001
...GKMFIG	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120872
...GKMFIG	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120873
...KMFIGG	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5120
...KMFIGG	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7004
...KMFIGG	153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120934
...KMFIGG	153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120935
...GGLSWD	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18216
...GGLSWD	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16866
...GGLSWD	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121265
...GGLSWD	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121266
...GLSWDT	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10689
...GLSWDT	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121405
...GLSWDT	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121406
...KVFVGG	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5123
...KVFVGG	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7007
...KVFVGG	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3257
...KVFVGG	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126682
...KVFVGG	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126683
...GLSPDT	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10692
...GLSPDT	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126955
...GLSPDT	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126956
...RRGFCF	277	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5126
...RRGFCF	277	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3260
...RRGFCF	277	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128366
...RRGFCF	277	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128368
...RGFCFI	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5129
...RGFCFI	278	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128403
...RGFCFI	278	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128404
...GFCFIT	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5132
...GFCFIT	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128459
...GFCFIT	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128460
...NYQPY	420	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NYQPY	420	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72761
...NYQPY	420	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72760

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	150	GKMF.\|.FIGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	152	MFIG.\|.GGLS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	153	FIGG.\|.GLSW	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	153	FIGG.\|.GLSW	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	157	LSWD.\|.DTSK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	157	LSWD.\|.DTSK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	158	SWDT.\|.TSKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	238	FVGG.\|.GLSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	238	FVGG.\|.GLSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	238	FVGG.\|.GLSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	243	SPDT.\|.TSEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	277	GFCF.\|.FITY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	277	GFCF.\|.FITY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	278	FCFI.\|.ITYT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	279	CFIT.\|.TYTD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)