P29692: Elongation factor 1-delta

General Information

Protein names	- Elongation factor 1-delta - EF-1-delta - Antigen NY-CO-4
Gene names	EEF1D
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P29692

17 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Elongation factor 1-delta - Isoform 3 of Elongation factor 1-delta - Isoform 4 of Elongation factor 1-delta

Sequence View

        10         20         30         40         50         60
MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVAGASRQE NGASVILRDI ARARENIQKS
        70         80         90        100        110        120
LAGSSGPGAS SGTSGDHGEL VVRIASLEVE NQSLRGVVQE LQQAISKLEA RLNVLEKSSP
       130        140        150        160        170        180
GHRATAPQTQ HVSPMRQVEP PAKKPATPAE DDEDDDIDLF GSDNEEEDKE AAQLREERLR
       190        200        210        220        230        240
QYAEKKAKKP ALVAKSSILL DVKPWDDETD MAQLEACVRS IQLDGLVWGA SKLVPVGYGI
       250        260        270        280
RKLQIQCVVE DDKVGTDLLE EEITKFEEHV QSVDIAAFNK I         10         20         30         40         50         60
MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVAGASRQE NGASVILRDI ARARENIQKS
        70         80         90        100        110        120
LAGSSGPGAS SGTSGDHGEL VVRIASLEVE NQSLRGVVQE LQQAISKLEA RLNVLEKSSP
       130        140        150        160        170        180
GHRATAPQTQ HVSPMRQVEP PAKKPATPAE DDEDDDIDLF GSDNEEEDKE AAQLREERLR
       190        200        210        220        230        240
QYAEKKAKKP ALVAKSSILL DVKPWDDETD MAQLEACVRS IQLDGLVWGA SKLVPVGYGI
       250        260        270        280
RKLQIQCVVE DDKVGTDLLE EEITKFEEHV QSVDIAAFNK I         10         20         30         40         50         60
MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVAGASRQE NGASVILRDI ARARENIQKS
        70         80         90        100        110        120
LAGSSGPGAS SGTSGDHGEL VVRIASLEVE NQSLRGVVQE LQQAISKLEA RLNVLEKSSP
       130        140        150        160        170        180
GHRATAPQTQ HVSPMRQVEP PAKKPATPAE DDEDDDIDLF GSDNEEEDKE AAQLREERLR
       190        200        210        220        230        240
QYAEKKAKKP ALVAKSSILL DVKPWDDETD MAQLEACVRS IQLDGLVWGA SKLVPVGYGI
       250        260        270        280
RKLQIQCVVE DDKVGTDLLE EEITKFEEHV QSVDIAAFNK I

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P29692-1-unknown	MATNFL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73654
P29692-1-unknown	MATNFL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73655
P29692-1-unknown	MATNFL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100184
P29692-2-unknown	MATNFL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P29692-2-Acetylation	ATNFLA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P29692-2-Acetylation	ATNFLA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P29692-2-Acetylation	ATNFLA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110564
P29692-2-Acetylation	ATNFLA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110565
P29692-2-Acetylation	ATNFLA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110566
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P29692-60-	SLAGSS...	60			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P29692-60-unknown	SLAGSS...	60			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P29692-60-unknown	SLAGSS...	60		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161499
P29692-63-unknown	GSSGPG...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5767
P29692-63-unknown	GSSGPG...	63		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152459
P29692-64-unknown	SSGPGA...	64		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167301
P29692-64-unknown	SSGPGA...	64		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167302
P29692-64-	SSGPGA...	64			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P29692-64-	SSGPGA...	64			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29692-64-	SSGPGA...	64			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P29692-70-	SSGTSG...	70			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29692-70-unknown	SSGTSG...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172692
P29692-70-unknown	SSGTSG...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172693
P29692-73-unknown	TSGDHG...	73		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3754
P29692-73-unknown	TSGDHG...	73		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152623
P29692-73-unknown	TSGDHG...	73		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196531
P29692-100-unknown	ELQQAI...	100		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19009
P29692-100-unknown	ELQQAI...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141028
P29692-100-unknown	ELQQAI...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153013
P29692-100-unknown	ELQQAI...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196588
P29692-159-unknown	LFGSDN...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165756
P29692-159-unknown	LFGSDN...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165755
P29692-159-unknown	LFGSDN...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165757
P29692-159-	LFGSDN...	159			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P29692-159-	LFGSDN...	159			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29692-159-	LFGSDN...	159			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P29692-159-	LFGSDN...	159			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P29692-165-unknown	EEEDKE...	165		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19012
P29692-165-unknown	EEEDKE...	165		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144342
P29692-165-unknown	EEEDKE...	165		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144557
P29692-165-unknown	EEEDKE...	165		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153756
P29692-201-unknown	DVKPWD...	201		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17552
P29692-201-unknown	DVKPWD...	201		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145799
P29692-201-unknown	DVKPWD...	201		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145975
P29692-201-unknown	DVKPWD...	201		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154188
P29692-258-unknown	LLEEEI...	258		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11428
P29692-258-unknown	LLEEEI...	258		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147886
P29692-258-unknown	LLEEEI...	258		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148039
P29692-258-unknown	LLEEEI...	258		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154951

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QKSLAG	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5767
...QKSLAG	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123298
...QKSLAG	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135870
...GASSGT	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3754
...GASSGT	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154069
...GASSGT	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136040
...RGVVQE	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19009
...RGVVQE	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124178
...RGVVQE	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136439
...FGSDNE	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19012
...FGSDNE	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127604
...FGSDNE	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127824
...FGSDNE	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137178
...SSILLD	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17552
...SSILLD	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129096
...SSILLD	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129274
...SSILLD	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137608
...KVGTDL	257	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11428
...KVGTDL	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131245
...KVGTDL	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131402
...KVGTDL	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138378
...AFNKI	281	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AFNKI	281	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69272
...AFNKI	281	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69273
...AFNKI	281	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69271

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	62	SLAG.\|.GSSG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	72	SSGT.\|.TSGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	99	VVQE.\|.ELQQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	164	SDNE.\|.EEED	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	200	ILLD.\|.DVKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	257	GTDL.\|.LLEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)