TopFIND 4.0

Q16630: Cleavage and polyadenylation specificity factor subunit 6 {ECO:0000305}

General Information

Protein names
- Cleavage and polyadenylation specificity factor subunit 6 {ECO:0000305}
- Cleavage and polyadenylation specificity factor 68 kDa subunit
- CPSF 68 kDa subunit
- Cleavage factor Im complex 68 kDa subunit {ECO:0000303|PubMed:9659921}
- CFIm68 {ECO:0000303|PubMed:9659921}
- Pre-mRNA cleavage factor Im 68 kDa subunit
- Protein HPBRII-4/7
Gene names CPSF6
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q16630

5

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV 
        70         80         90        100        110        120 
GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN 
       130        140        150        160        170        180 
GQSKGFALVG VGSEASSKKL MDLLPKRELH GQNPVVTPCN KQFLSQFEMQ SRKTTQSGQM 
       190        200        210        220        230        240 
SGEGKAGPPG GSSRAAFPQG GRGRGRFPGA VPGGDRFPGP AGPGGPPPPF PAGQTPPRPP 
       250        260        270        280        290        300 
LGPPGPPGPP GPPPPGQVLP PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV 
       310        320        330        340        350        360 
PGYGPPPGPP PPQQGPPPPP GPFPPRPPGP LGPPLTLAPP PHLPGPPPGA PPPAPHVNPA 
       370        380        390        400        410        420 
FFPPPTNSGM PTSDSRGPPP TDPYGRPPPY DRGDYGPPGR EMDTARTPLS EAEFEEIMNR 
       430        440        450        460        470        480 
NRAISSSAIS RAVSDASAGD YGSAIETLVT AISLIKQSKV SADDRCKVLI SSLQDCLHGI 
       490        500        510        520        530        540 
ESKSYGSGSR RERSRERDHS RSREKSRRHK SRSRDRHDDY YRERSRERER HRDRDRDRDR 
       550    
ERDREREYRH R

Isoforms

- Isoform 2 of Cleavage and polyadenylation specificity factor subunit 6 - Isoform 3 of Cleavage and polyadenylation specificity factor subunit 6

Sequence View

        10         20         30         40         50         60 
MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV 
        70         80         90        100        110        120 
GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN 
       130        140        150        160        170        180 
GQSKGFALVG VGSEASSKKL MDLLPKRELH GQNPVVTPCN KQFLSQFEMQ SRKTTQSGQM 
       190        200        210        220        230        240 
SGEGKAGPPG GSSRAAFPQG GRGRGRFPGA VPGGDRFPGP AGPGGPPPPF PAGQTPPRPP 
       250        260        270        280        290        300 
LGPPGPPGPP GPPPPGQVLP PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV 
       310        320        330        340        350        360 
PGYGPPPGPP PPQQGPPPPP GPFPPRPPGP LGPPLTLAPP PHLPGPPPGA PPPAPHVNPA 
       370        380        390        400        410        420 
FFPPPTNSGM PTSDSRGPPP TDPYGRPPPY DRGDYGPPGR EMDTARTPLS EAEFEEIMNR 
       430        440        450        460        470        480 
NRAISSSAIS RAVSDASAGD YGSAIETLVT AISLIKQSKV SADDRCKVLI SSLQDCLHGI 
       490        500        510        520        530        540 
ESKSYGSGSR RERSRERDHS RSREKSRRHK SRSRDRHDDY YRERSRERER HRDRDRDRDR 
       550    
ERDREREYRH R         10         20         30         40         50         60 
MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV 
        70         80         90        100        110        120 
GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN 
       130        140        150        160        170        180 
GQSKGFALVG VGSEASSKKL MDLLPKRELH GQNPVVTPCN KQFLSQFEMQ SRKTTQSGQM 
       190        200        210        220        230        240 
SGEGKAGPPG GSSRAAFPQG GRGRGRFPGA VPGGDRFPGP AGPGGPPPPF PAGQTPPRPP 
       250        260        270        280        290        300 
LGPPGPPGPP GPPPPGQVLP PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV 
       310        320        330        340        350        360 
PGYGPPPGPP PPQQGPPPPP GPFPPRPPGP LGPPLTLAPP PHLPGPPPGA PPPAPHVNPA 
       370        380        390        400        410        420 
FFPPPTNSGM PTSDSRGPPP TDPYGRPPPY DRGDYGPPGR EMDTARTPLS EAEFEEIMNR 
       430        440        450        460        470        480 
NRAISSSAIS RAVSDASAGD YGSAIETLVT AISLIKQSKV SADDRCKVLI SSLQDCLHGI 
       490        500        510        520        530        540 
ESKSYGSGSR RERSRERDHS RSREKSRRHK SRSRDRHDDY YRERSRERER HRDRDRDRDR 
       550    
ERDREREYRH R



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)