TopFIND 4.0

P01584: Interleukin-1 beta {ECO:0000303|PubMed:1919436}

General Information

Protein names	- Interleukin-1 beta {ECO:0000303\|PubMed:1919436} - IL-1 beta {ECO:0000303\|PubMed:1919436} - Catabolin
Gene names	IL1B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01584

9 N-termini

12 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG
        70         80         90        100        110        120
FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR
       130        140        150        160        170        180
SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE
       190        200        210        220        230        240
KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST
       250        260
SQAENMPVFL GGTKGGQDIT DFTMQFVSS

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 12 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01584-13-	AYYSGN...	13		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P01584-28-unknown	GPKQMK...	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2375
P01584-28-unknown	GPKQMK...	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1119
P01584-104-unknown	FFDTWD...	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8343
P01584-111-unknown	EAYVHD...	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18364
P01584-114-unknown	VHDAPV...	114	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4749
P01584-114-unknown	VHDAPV...	114	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8377
P01584-114-unknown	VHDAPV...	114	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8645
P01584-116-unknown	DAPVRS...	116	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17024
P01584-117-unknown	APVRSL...	117	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01584-117-unknown	APVRSL...	117	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2376
P01584-117-unknown	APVRSL...	117	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1120
P01584-121-unknown	SLNCTL...	121	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9929
P01584-142-unknown	LKALHL...	142	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC22093

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FFEADG	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2375
...FFEADG	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1119
...EEEPIF	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8343
...DTWDNE	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18364
...TWDNEA	111	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400854
...DNEAYV	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4749
...DNEAYV	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8377
...DNEAYV	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8645
...EAYVHD	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17024
...AYVHDA	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2376
...AYVHDA	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1120
...DAPVRS	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9929
...SLNCTL	125	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409680
...SGPYEL	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22093
...PYELKA	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407219
...QFVSS	269	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP4_HUMAN	27	EADG.\|.GPKQ	inferred from experiment	unknown	MEROPS	et al.	Kamens J et al.:Identification and characteriza... (C14.007)	7797510,
CASP1_HUMAN	27	EADG.\|.GPKQ	inferred from experiment	unknown	MEROPS	Nicholson DW	Thornberry NA et al.:A combinatorial approach define... (C14.001)	9218414,
CELA1_HUMAN	103	EPIF.\|.FFDT	inferred from experiment	unknown	MEROPS	Young PR	Hazuda DJ et al.:Processing of precursor interle... (S01.133)	2156847,
MEP1B_HUMAN	110	WDNE.\|.EAYV	inferred from experiment	unknown	MEROPS	Haun RS	Herzog C et al.:Generation of biologically acti... (M12.004)	16095909,
CATG_HUMAN	113	EAYV.\|.VHDA	inferred from experiment	unknown	MEROPS	Young PR	Hazuda DJ et al.:Processing of precursor interle... (S01.133)	2156847,
CMA1_HUMAN	113	EAYV.\|.VHDA	inferred from experiment	unknown	MEROPS	Caughey GH	Raymond WW et al.:Albumin is a substrate of human... (S01.140)	12815038,
ELNE_HUMAN	113	EAYV.\|.VHDA	inferred from experiment	unknown	MEROPS	Young PR	Hazuda DJ et al.:Processing of precursor interle... (S01.133)	2156847,
MEP1A_HUMAN	115	YVHD.\|.DAPV	inferred from experiment	unknown	MEROPS	Kaushal GP	Herzog C et al.:Meprin A and meprin alpha gener... (M12.002)	19135030,
CASP4_HUMAN	116	VHDA.\|.APVR	inferred from experiment	unknown	MEROPS	et al.	Kamens J et al.:Identification and characteriza... (C14.007)	7797510,
CASP1_HUMAN	116	VHDA.\|.APVR	inferred from experiment	unknown	MEROPS	et al.	Thornberry NA et al.:A novel heterodimeric cysteine ... (C14.001)	1574116,
GRAA_HUMAN	120	PVRS.\|.SLNC	inferred from experiment	unknown	MEROPS		Merops GRAA_HUMAN -> IL1B_HUMAN @120
MMP2_HUMAN	141	PYEL.\|.LKAL	inferred from experiment	unknown	MEROPS	Mori Y	Ito A et al.:Degradation of interleukin 1bet... (M10.003)	8663297,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)