P49368: T-complex protein 1 subunit gamma

General Information

Protein names	- T-complex protein 1 subunit gamma - TCP-1-gamma - CCT-gamma - hTRiC5
Gene names	CCT3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49368

12 N-termini

4 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMGHRPVLVL SQNTKRESGR KVQSGNINAA KTIADIIRTC LGPKSMMKML LDPMGGIVMT
        70         80         90        100        110        120
NDGNAILREI QVQHPAAKSM IEISRTQDEE VGDGTTSVII LAGEMLSVAE HFLEQQMHPT
       130        140        150        160        170        180
VVISAYRKAL DDMISTLKKI SIPVDISDSD MMLNIINSSI TTKAISRWSS LACNIALDAV
       190        200        210        220        230        240
KMVQFEENGR KEIDIKKYAR VEKIPGGIIE DSCVLRGVMI NKDVTHPRMR RYIKNPRIVL
       250        260        270        280        290        300
LDSSLEYKKG ESQTDIEITR EEDFTRILQM EEEYIQQLCE DIIQLKPDVV ITEKGISDLA
       310        320        330        340        350        360
QHYLMRANIT AIRRVRKTDN NRIARACGAR IVSRPEELRE DDVGTGAGLL EIKKIGDEYF
       370        380        390        400        410        420
TFITDCKDPK ACTILLRGAS KEILSEVERN LQDAMQVCRN VLLDPQLVPG GGASEMAVAH
       430        440        450        460        470        480
ALTEKSKAMT GVEQWPYRAV AQALEVIPRT LIQNCGASTI RLLTSLRAKH TQENCETWGV
       490        500        510        520        530        540
NGETGTLVDM KELGIWEPLA VKLQTYKTAV ETAVLLLRID DIVSGHKKKG DDQSRQGGAP

DAGQE

Isoforms

- Isoform 2 of T-complex protein 1 subunit gamma

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49368-1-unknown	MMGHRP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91753
P49368-1-Acetylation	MMGHRP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49368-1-Acetylation	MMGHRP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100920
P49368-3-	GHRPVL...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49368-3-	GHRPVL...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49368-3-	GHRPVL...	3			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49368-3-	GHRPVL...	3			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49368-3-unknown	GHRPVL...	3			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49368-3-unknown	GHRPVL...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160353
P49368-252-unknown	SQTDIE...	252		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173473
P49368-252-	SQTDIE...	252			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49368-285-unknown	LKPDVV...	285		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17677
P49368-285-unknown	LKPDVV...	285		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5926
P49368-285-unknown	LKPDVV...	285		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7507
P49368-285-unknown	LKPDVV...	285		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148307
P49368-342-unknown	DVGTGA...	342		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19154
P49368-342-unknown	DVGTGA...	342		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149990
P49368-343-unknown	VGTGAG...	343		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19156
P49368-343-unknown	VGTGAG...	343		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150011
P49368-390-acetylation	NLQDAM...	390	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P49368-390-acetylation	NLQDAM...	390	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182746
P49368-439-	AVAQAL...	439			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49368-439-	AVAQAL...	439			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49368-439-	AVAQAL...	439			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49368-439-	AVAQAL...	439			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49368-439-unknown	AVAQAL...	439		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167188

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDIIQL	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17677
...EDIIQL	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5926
...EDIIQL	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7507
...EDIIQL	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131677
...ELREDD	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19154
...ELREDD	341	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133382
...LREDDV	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19156
...LREDDV	342	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133403
...DAGQE	545	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DAGQE	545	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87371

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	284	IIQL.\|.LKPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	284	IIQL.\|.LKPD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	284	IIQL.\|.LKPD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	341	REDD.\|.DVGT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	342	EDDV.\|.VGTG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)