P14625: Endoplasmin

General Information

Protein names	- Endoplasmin - 94 kDa glucose-regulated protein - GRP-94 - Heat shock protein 90 kDa beta member 1 - Tumor rejection antigen 1 - gp96 homolog
Gene names	HSP90B1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14625

16 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRALWVLGLC CVLLTFGSVR ADDEVDVDGT VEEDLGKSRE GSRTDDEVVQ REEEAIQLDG
        70         80         90        100        110        120
LNASQIRELR EKSEKFAFQA EVNRMMKLII NSLYKNKEIF LRELISNASD ALDKIRLISL
       130        140        150        160        170        180
TDENALSGNE ELTVKIKCDK EKNLLHVTDT GVGMTREELV KNLGTIAKSG TSEFLNKMTE
       190        200        210        220        230        240
AQEDGQSTSE LIGQFGVGFY SAFLVADKVI VTSKHNNDTQ HIWESDSNEF SVIADPRGNT
       250        260        270        280        290        300
LGRGTTITLV LKEEASDYLE LDTIKNLVKK YSQFINFPIY VWSSKTETVE EPMEEEEAAK
       310        320        330        340        350        360
EEKEESDDEA AVEEEEEEKK PKTKKVEKTV WDWELMNDIK PIWQRPSKEV EEDEYKAFYK
       370        380        390        400        410        420
SFSKESDDPM AYIHFTAEGE VTFKSILFVP TSAPRGLFDE YGSKKSDYIK LYVRRVFITD
       430        440        450        460        470        480
DFHDMMPKYL NFVKGVVDSD DLPLNVSRET LQQHKLLKVI RKKLVRKTLD MIKKIADDKY
       490        500        510        520        530        540
NDTFWKEFGT NIKLGVIEDH SNRTRLAKLL RFQSSHHPTD ITSLDQYVER MKEKQDKIYF
       550        560        570        580        590        600
MAGSSRKEAE SSPFVERLLK KGYEVIYLTE PVDEYCIQAL PEFDGKRFQN VAKEGVKFDE
       610        620        630        640        650        660
SEKTKESREA VEKEFEPLLN WMKDKALKDK IEKAVVSQRL TESPCALVAS QYGWSGNMER
       670        680        690        700        710        720
IMKAQAYQTG KDISTNYYAS QKKTFEINPR HPLIRDMLRR IKEDEDDKTV LDLAVVLFET
       730        740        750        760        770        780
ATLRSGYLLP DTKAYGDRIE RMLRLSLNID PDAKVEEEPE EEPEETAEDT TEDTEQDEDE
       790        800
EMDVGTDEEE ETAKESTAEK DEL

Isoforms

Sequence View

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Physiological Relevance:

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Evidence Names:

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Protein Neighborhood

Domains & Features

16 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P14625-22-	DDEVDV...	22		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P14625-22-unknown	DDEVDV...	22	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14625-29-unknown	GTVEED...	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3219
P14625-29-unknown	GTVEED...	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11220
P14625-29-unknown	GTVEED...	29		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14625-29-	GTVEED...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P14625-29-	GTVEED...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
P14625-29-	GTVEED...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P14625-29-	GTVEED...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14625-29-	GTVEED...	29		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P14625-29-	GTVEED...	29		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14625-85-unknown	MMKLII...	85	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446748
P14625-125-	ALSGNE...	125		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P14625-250-unknown	VLKEEA...	250	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P14625-332-unknown	DWELMN...	332	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18751
P14625-332-unknown	DWELMN...	332	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17358
P14625-346-	PSKEVE...	346		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P14625-435-	GVVDSD...	435		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14625-513-	QSSHHP...	513		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14625-579-unknown	ALPEFD...	579	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5612
P14625-725-	SGYLLP...	725		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14625-746-	SLNIDP...	746		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14625-753-unknown	AKVEEE...	753	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11221
P14625-788-unknown	EEEETA...	788	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2539

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVDVDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3219
...EVDVDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11220
...GNEELT	132	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446748
...EKTVWD	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18751
...EKTVWD	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17358
...EYCIQA	578	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5612
...NIDPDA	752	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11221
...DVGTDE	787	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2539
...TAEKDE	801	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2540
...EKDEL	803	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASPE_HUMAN	28	DVDG.\|.GTVE	inferred from experiment	unknown	MEROPS		Merops CASPE_HUMAN -> ENPL_HUMAN @28
GRAB_HUMAN	28	DVDG.\|.GTVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	331	TVWD.\|.DWEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	331	TVWD.\|.DWEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	578	CIQA.\|.ALPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	752	DPDA.\|.AKVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP6_HUMAN	787	GTDE.\|.EEEE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	801	EKDE.\|.EL	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)