Q7KZF4: Staphylococcal nuclease domain-containing protein 1

General Information

Protein names	- Staphylococcal nuclease domain-containing protein 1 - 3.1.31.1 {ECO:0000269\|PubMed:18453631, ECO:0000269\|PubMed:28546213} - 100 kDa coactivator - EBNA2 coactivator p100 - Tudor domain-containing protein 11 - p100 co-activator
Gene names	SND1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7KZF4

18 N-termini

10 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASSAQSGGS SGGPAVPTVQ RGIIKMVLSG CAIIVRGQPR GGPPPERQIN LSNIRAGNLA
        70         80         90        100        110        120
RRAAATQPDA KDTPDEPWAF PAREFLRKKL IGKEVCFTIE NKTPQGREYG MIYLGKDTNG
       130        140        150        160        170        180
ENIAESLVAE GLATRREGMR ANNPEQNRLS ECEEQAKAAK KGMWSEGNGS HTIRDLKYTI
       190        200        210        220        230        240
ENPRHFVDSH HQKPVNAIIE HVRDGSVVRA LLLPDYYLVT VMLSGIKCPT FRREADGSET
       250        260        270        280        290        300
PEPFAAEAKF FTESRLLQRD VQIILESCHN QNILGTILHP NGNITELLLK EGFARCVDWS
       310        320        330        340        350        360
IAVYTRGAEK LRAAERFAKE RRLRIWRDYV APTANLDQKD KQFVAKVMQV LNADAIVVKL
       370        380        390        400        410        420
NSGDYKTIHL SSIRPPRLEG ENTQDKNKKL RPLYDIPYMF EAREFLRKKL IGKKVNVTVD
       430        440        450        460        470        480
YIRPASPATE TVPAFSERTC ATVTIGGINI AEALVSKGLA TVIRYRQDDD QRSSHYDELL
       490        500        510        520        530        540
AAEARAIKNG KGLHSKKEVP IHRVADISGD TQKAKQFLPF LQRAGRSEAV VEYVFSGSRL
       550        560        570        580        590        600
KLYLPKETCL ITFLLAGIEC PRGARNLPGL VQEGEPFSEE ATLFTKELVL QREVEVEVES
       610        620        630        640        650        660
MDKAGNFIGW LHIDGANLSV LLVEHALSKV HFTAERSSYY KSLLSAEEAA KQKKEKVWAH
       670        680        690        700        710        720
YEEQPVEEVM PVLEEKERSA SYKPVFVTEI TDDLHFYVQD VETGTQLEKL MENMRNDIAS
       730        740        750        760        770        780
HPPVEGSYAP RRGEFCIAKF VDGEWYRARV EKVESPAKIH VFYIDYGNRE VLPSTRLGTL
       790        800        810        820        830        840
SPAFSTRVLP AQATEYAFAF IQVPQDDDAR TDAVDSVVRD IQNTQCLLNV EHLSAGCPHV
       850        860        870        880        890        900
TLQFADSKGD VGLGLVKEGL VMVEVRKEKQ FQKVITEYLN AQESAKSARL NLWRYGDFRA
       910
DDADEFGYSR

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

18 N-termini - 10 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7KZF4-2-unknown	MASSAQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7KZF4-2-Acetylation	ASSAQS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7KZF4-2-Acetylation	ASSAQS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q7KZF4-2-Acetylation	ASSAQS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q7KZF4-2-Acetylation	ASSAQS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q7KZF4-189-	SHHQKP...	189			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7KZF4-189-	SHHQKP...	189			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q7KZF4-189-	SHHQKP...	189			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7KZF4-189-	SHHQKP...	189			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7KZF4-352-unknown	NADAIV...	352		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6559
Q7KZF4-388-unknown	KKLRPL...	388		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14649
Q7KZF4-447-unknown	GINIAE...	447		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6560
Q7KZF4-452-unknown	EALVSK...	452		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419327
Q7KZF4-511-unknown	TQKAKQ...	511		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12665
Q7KZF4-569-	GLVQEG...	569			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7KZF4-569-	GLVQEG...	569			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q7KZF4-569-	GLVQEG...	569			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7KZF4-637-	SSYYKS...	637			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q7KZF4-642-	SLLSAE...	642			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7KZF4-642-	SLLSAE...	642			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7KZF4-657-	VWAHYE...	657			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7KZF4-657-	VWAHYE...	657			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7KZF4-657-	VWAHYE...	657			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7KZF4-659-	AHYEEQ...	659			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7KZF4-659-	AHYEEQ...	659			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7KZF4-679-	SASYKP...	679			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7KZF4-700-unknown	DVETGT...	700		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18011
Q7KZF4-700-unknown	DVETGT...	700		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19655
Q7KZF4-720-unknown	SHPPVE...	720		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6561
Q7KZF4-720-	SHPPVE...	720			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7KZF4-721-unknown	HPPVEG...	721		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19656

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VMQVLN	351	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6559
...TQDKNK	387	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14649
...TVTIGG	446	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6560
...DISGDT	510	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12665
...HFYVQD	699	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18011
...HFYVQD	699	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19655
...RNDIAS	719	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6561
...NDIASH	720	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19656
...VDGEWY	745	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419327
...FGYSR	910	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...FGYSR	910		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FGYSR	910		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...FGYSR	910		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FGYSR	910		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	351	QVLN.\|.NADA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	387	DKNK.\|.KKLR	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	446	TIGG.\|.GINI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	510	SGDT.\|.TQKA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1A_HUMAN	699	YVQD.\|.DVET	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	699	YVQD.\|.DVET	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	719	DIAS.\|.SHPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	720	IASH.\|.HPPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)