P52565: Rho GDP-dissociation inhibitor 1

General Information

Protein names	- Rho GDP-dissociation inhibitor 1 - Rho GDI 1 - Rho-GDI alpha
Gene names	ARHGDIA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52565

21 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA
        70         80         90        100        110        120
VSADPNVPNV VVTGLTLVCS SAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR
       130        140        150        160        170        180
EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PVEEAPKGML ARGSYSIKSR
       190        200
FTDDDKTDHL SWEWNLTIKK DWKD

Isoforms

- Isoform 2 of Rho GDP-dissociation inhibitor 1

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

21 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52565-2-unknown	MAEQEP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52565-2-unknown	MAEQEP...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52565-1-unknown	MAEQEP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75839
P52565-2-Acetylation	AEQEPT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52565-2-Acetylation	AEQEPT...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P52565-2-Acetylation	AEQEPT...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P52565-2-Acetylation	AEQEPT...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110264
P52565-11-	LAQIAA...	11			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52565-11-	LAQIAA...	11			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52565-11-	LAQIAA...	11			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52565-11-unknown	LAQIAA...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170513
P52565-13-	QIAAEN...	13			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52565-13-	QIAAEN...	13			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52565-13-unknown	QIAAEN...	13		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170511
P52565-21-unknown	DEHSVN...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19185
P52565-21-unknown	DEHSVN...	21		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136947
P52565-22-	EHSVNY...	22			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52565-22-unknown	EHSVNY...	22		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174973
P52565-24-	SVNYKP...	24			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52565-24-unknown	SVNYKP...	24		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172382
P52565-34-	SIQEIQ...	34			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52565-34-	SIQEIQ...	34			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52565-34-	SIQEIQ...	34			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52565-34-	SIQEIQ...	34			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52565-34-	SIQEIQ...	34			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52565-34-unknown	SIQEIQ...	34		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170509
P52565-38-unknown	IQELDK...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17713
P52565-38-unknown	IQELDK...	38		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138163
P52565-40-unknown	ELDKDD...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7544
P52565-40-unknown	ELDKDD...	40		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138341
P52565-81-	SAPGPL...	81			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52565-81-unknown	SAPGPL...	81		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170515
P52565-90-unknown	LTGDLE...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7546
P52565-90-unknown	LTGDLE...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141827
P52565-144-	YMVGSY...	144			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52565-144-	YMVGSY...	144			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52565-144-	YMVGSY...	144			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52565-144-	YMVGSY...	144			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52565-148-	SYGPRA...	148			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52565-148-	SYGPRA...	148			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52565-148-	SYGPRA...	148			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AENEED	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19185
...KSIQEI	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17713
...KSIQEI	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121189
...IQEIQE	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7544
...IQEIQE	39	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121378
...PLELDL	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7546
...PLELDL	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125006
...KDWKD	204	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KDWKD	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71457

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	20	NEED.\|.DEHS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	37	IQEI.\|.IQEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	39	EIQE.\|.ELDK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	89	ELDL.\|.LTGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)