P50454: Serpin H1

General Information

Protein names	- Serpin H1 - 47 kDa heat shock protein - Arsenic-transactivated protein 3 - AsTP3 - Cell proliferation-inducing gene 14 protein - Collagen-binding protein - Colligin - Rheumatoid arthritis-related antigen RA-A47
Gene names	SERPINH1
Organism	Homo sapiens
Protease Family
Protease ID	I04.035
Chromosome location
UniProt ID	P50454

9 N-termini

13 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK
        70         80         90        100        110        120
DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAG LGELLRSLSN
       130        140        150        160        170        180
STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT
       190        200        210        220        230        240
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT
       250        260        270        280        290        300
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK
       310        320        330        340        350        360
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD
       370        380        390        400        410
TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 13 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50454-19-unknown	AEVKKP...	19	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50454-19-	AEVKKP...	19		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P50454-19-	AEVKKP...	19		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P50454-19-	AEVKKP...	19		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50454-104-unknown	DEEVHA...	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17685
P50454-104-unknown	DEEVHA...	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19166
P50454-106-unknown	EVHAGL...	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19167
P50454-139-	SVSFAD...	139		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50454-172-	SINEWA...	172		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50454-175-unknown	EWAAQT...	175	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17686
P50454-175-unknown	EWAAQT...	175	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19168
P50454-183-	GKLPEV...	183		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50454-218-unknown	MVDNRG...	218	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433532

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AEQLRD	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17685
...AEQLRD	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19166
...QLRDEE	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19167
...EVHAGL	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431384
...FVRSSK	150	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431827
...INFRDK	165	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432007
...NFRDKR	166	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435936
...LQSINE	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17686
...LQSINE	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19168
...LPEVTK	189	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434482
...LLVNAM	203	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437108
...YNYYDD	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435452
...YYDDEK	249	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434964
...KIWMGK	295	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436040
...MRDEL	418	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	103	QLRD.\|.DEEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	103	QLRD.\|.DEEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	105	RDEE.\|.EVHA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	174	SINE.\|.EWAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	174	SINE.\|.EWAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)