Q8IYB3: Serine/arginine repetitive matrix protein 1

General Information

Protein names	- Serine/arginine repetitive matrix protein 1 - SR-related nuclear matrix protein of 160 kDa - SRm160 - Ser/Arg-related nuclear matrix protein
Gene names	SRRM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IYB3

19 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP WITKRVTEIL
        70         80         90        100        110        120
GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE FMGELWPLLL SAQENIAGIP
       130        140        150        160        170        180
SAFLELKKEE IKQRQIEQEK LASMKKQDED KDKRDKEEKE SSREKRERSR SPRRRKSRSP
       190        200        210        220        230        240
SPRRRSSPVR RERKRSHSRS PRHRTKSRSP SPAPEKKEKT PELPEPSVKV KEPSVQEATS
       250        260        270        280        290        300
TSDILKVPKP EPIPEPKEPS PEKNSKKEKE KEKTRPRSRS RSKSRSRTRS RSPSHTRPRR
       310        320        330        340        350        360
RHRSRSRSYS PRRRPSPRRR PSPRRRTPPR RMPPPPRHRR SRSPVRRRRR SSASLSGSSS
       370        380        390        400        410        420
SSSSSRSRSP PKKPPKRTSS PPRKTRRLSP SASPPRRRHR PSPPATPPPK TRHSPTPQQS
       430        440        450        460        470        480
NRTRKSRVSV SPGRTSGKVT KHKGTEKRES PSPAPKPRKV ELSESEEDKG GKMAAADSVQ
       490        500        510        520        530        540
QRRQYRRQNQ QSSSDSGSSS SSEDERPKRS HVKNGEVGRR RRHSPSRSAS PSPRKRQKET
       550        560        570        580        590        600
SPRGRRRRSP SPPPTRRRRS PSPAPPPRRR RTPTPPPRRR TPSPPPRRRS PSPRRYSPPI
       610        620        630        640        650        660
QRRYSPSPPP KRRTASPPPP PKRRASPSPP PKRRVSHSPP PKQRSSPVTK RRSPSLSSKH
       670        680        690        700        710        720
RKGSSPSRST REARSPQPNK RHSPSPRPRA PQTSSSPPPV RRGASSSPQR RQSPSPSTRP
       730        740        750        760        770        780
IRRVSRTPEP KKIKKAASPS PQSVRRVSSS RSVSGSPEPA AKKPPAPPSP VQSQSPSTNW
       790        800        810        820        830        840
SPAVPVKKAK SPTPSPSPPR NSDQEGGGKK KKKKKDKKHK KDKKHKKHKK HKKEKAVAAA
       850        860        870        880        890        900
AAAAVTPAAI AAATTTLAQE EPVAAPEPKK ETESEAEDNL DDLEKHLREK ALRSMRKAQV

SPQS

Isoforms

- Isoform 2 of Serine/arginine repetitive matrix protein 1

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

19 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IYB3-1-unknown	MDAGFF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90704
Q8IYB3-1-Acetylation	MDAGFF...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IYB3-1-Acetylation	MDAGFF...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8IYB3-1-Acetylation	MDAGFF...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q8IYB3-1-Acetylation	MDAGFF...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8IYB3-1-Acetylation	MDAGFF...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108938
Q8IYB3-459-unknown	KVELSE...	459		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10422
Q8IYB3-459-unknown	KVELSE...	459		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152875
Q8IYB3-459-	KVELSE...	459			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8IYB3-459-	KVELSE...	459			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8IYB3-463-unknown	SESEED...	463		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14729
Q8IYB3-463-unknown	SESEED...	463		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152927
Q8IYB3-469-unknown	KGGKMA...	469		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12827
Q8IYB3-469-unknown	KGGKMA...	469		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153030
Q8IYB3-752-	SVSGSP...	752			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8IYB3-752-unknown	SVSGSP...	752			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8IYB3-752-unknown	SVSGSP...	752		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162162
Q8IYB3-755-unknown	GSPEPA...	755		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167919
Q8IYB3-755-	GSPEPA...	755			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8IYB3-842-unknown	AAAVTP...	842		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164307
Q8IYB3-842-	AAAVTP...	842			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8IYB3-842-	AAAVTP...	842			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IYB3-842-	AAAVTP...	842			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IYB3-844-unknown	AVTPAA...	844		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170994
Q8IYB3-844-	AVTPAA...	844			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IYB3-844-	AVTPAA...	844			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IYB3-853-unknown	ATTTLA...	853			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8IYB3-853-unknown	ATTTLA...	853		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162160
Q8IYB3-853-	ATTTLA...	853			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8IYB3-853-	ATTTLA...	853			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8IYB3-853-	ATTTLA...	853			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q8IYB3-853-	ATTTLA...	853			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IYB3-853-	ATTTLA...	853			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IYB3-858-unknown	AQEEPV...	858			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8IYB3-858-unknown	AQEEPV...	858		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160313
Q8IYB3-858-	AQEEPV...	858			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8IYB3-877-unknown	EDNLDD...	877		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18031
Q8IYB3-877-unknown	EDNLDD...	877		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19685
Q8IYB3-877-unknown	EDNLDD...	877		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156763

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...APKPRK	458	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10422
...APKPRK	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136300
...RKVELS	462	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14729
...RKVELS	462	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136353
...ESEEDK	468	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12827
...ESEEDK	468	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136456
...TESEAE	876	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18031
...TESEAE	876	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19685
...TESEAE	876	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140253
...VSPQS	904	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VSPQS	904	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt86322
...VSPQS	904		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VSPQS	904		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VSPQS	904		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VSPQS	904		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	458	KPRK.\|.KVEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	462	VELS.\|.SESE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	468	EEDK.\|.KGGK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1A_HUMAN	876	SEAE.\|.EDNL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	876	SEAE.\|.EDNL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)