Q99832: T-complex protein 1 subunit eta

General Information

Protein names	- T-complex protein 1 subunit eta - TCP-1-eta - CCT-eta - HIV-1 Nef-interacting protein - T-complex protein 1 subunit eta, N-terminally processed
Gene names	CCT7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99832

28 N-termini

9 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of T-complex protein 1 subunit eta - Isoform 3 of T-complex protein 1 subunit eta - Isoform 4 of T-complex protein 1 subunit eta

Sequence View

        10         20         30         40         50         60
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV DGRGKATISN
        70         80         90        100        110        120
DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL AAEFLKQVKP YVEEGLHPQI
       130        140        150        160        170        180
IIRAFRTATQ LAVNKIKEIA VTVKKADKVE QRKLLEKCAM TALSSKLISQ QKAFFAKMVV
       190        200        210        220        230        240
DAVMMLDDLL QLKMIGIKKV QGGALEDSQL VAGVAFKKTF SYAGFEMQPK KYHNPKIALL
       250        260        270        280        290        300
NVELELKAEK DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT
       310        320        330        340        350        360
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSAD VLGRCQVFEE TQIGGERYNF
       370        380        390        400        410        420
FTGCPKAKTC TFILRGGAEQ FMEETERSLH DAIMIVRRAI KNDSVVAGGG AIEMELSKYL
       430        440        450        460        470        480
RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC DNAGFDATNI LNKLRARHAQ GGTWYGVDIN
       490        500        510        520        530        540
NEDIADNFEA FVWEPAMVRI NALTAASEAA CLIVSVDETI KNPRSTVDAP TAAGRGRGRG

RPH         10         20         30         40         50         60
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV DGRGKATISN
        70         80         90        100        110        120
DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL AAEFLKQVKP YVEEGLHPQI
       130        140        150        160        170        180
IIRAFRTATQ LAVNKIKEIA VTVKKADKVE QRKLLEKCAM TALSSKLISQ QKAFFAKMVV
       190        200        210        220        230        240
DAVMMLDDLL QLKMIGIKKV QGGALEDSQL VAGVAFKKTF SYAGFEMQPK KYHNPKIALL
       250        260        270        280        290        300
NVELELKAEK DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT
       310        320        330        340        350        360
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSAD VLGRCQVFEE TQIGGERYNF
       370        380        390        400        410        420
FTGCPKAKTC TFILRGGAEQ FMEETERSLH DAIMIVRRAI KNDSVVAGGG AIEMELSKYL
       430        440        450        460        470        480
RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC DNAGFDATNI LNKLRARHAQ GGTWYGVDIN
       490        500        510        520        530        540
NEDIADNFEA FVWEPAMVRI NALTAASEAA CLIVSVDETI KNPRSTVDAP TAAGRGRGRG

RPH         10         20         30         40         50         60
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV DGRGKATISN
        70         80         90        100        110        120
DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL AAEFLKQVKP YVEEGLHPQI
       130        140        150        160        170        180
IIRAFRTATQ LAVNKIKEIA VTVKKADKVE QRKLLEKCAM TALSSKLISQ QKAFFAKMVV
       190        200        210        220        230        240
DAVMMLDDLL QLKMIGIKKV QGGALEDSQL VAGVAFKKTF SYAGFEMQPK KYHNPKIALL
       250        260        270        280        290        300
NVELELKAEK DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT
       310        320        330        340        350        360
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSAD VLGRCQVFEE TQIGGERYNF
       370        380        390        400        410        420
FTGCPKAKTC TFILRGGAEQ FMEETERSLH DAIMIVRRAI KNDSVVAGGG AIEMELSKYL
       430        440        450        460        470        480
RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC DNAGFDATNI LNKLRARHAQ GGTWYGVDIN
       490        500        510        520        530        540
NEDIADNFEA FVWEPAMVRI NALTAASEAA CLIVSVDETI KNPRSTVDAP TAAGRGRGRG

RPH

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

28 N-termini - 9 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99832-1-	MMPTPV...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99832-1-	MMPTPV...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99832-1-	MMPTPV...	1			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q99832-1-	MMPTPV...	1			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99832-1-Acetylation	MMPTPV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99832-1-Acetylation	MMPTPV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99832-1-Acetylation	MMPTPV...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q99832-2-unmodified	MPTPVI...	2			other		CNRS/ISV	Large_scale_NTA_Human
Q99832-3-unknown	PTPVIL...	3		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q99832-45-unknown	MDKLIV...	45		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91755
Q99832-71-unknown	VVHPAA...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6713
Q99832-71-unknown	VVHPAA...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137327
Q99832-114-unknown	EGLHPQ...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19754
Q99832-114-unknown	EGLHPQ...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6715
Q99832-114-unknown	EGLHPQ...	114		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137325
Q99832-114-unknown	EGLHPQ...	114		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140614
Q99832-207-unknown	DSQLVA...	207		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19757
Q99832-207-unknown	DSQLVA...	207		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143463
Q99832-207-unknown	DSQLVA...	207		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145263
Q99832-207-unknown	DSQLVA...	207		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197231
Q99832-221-unknown	SYAGFE...	221		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178093
Q99832-221-unknown	SYAGFE...	221		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178091
Q99832-221-unknown	SYAGFE...	221		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178092
Q99832-221-	SYAGFE...	221			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99832-222-unknown	YAGFEM...	222		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4223
Q99832-222-unknown	YAGFEM...	222		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136724
Q99832-222-unknown	YAGFEM...	222		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144077
Q99832-222-unknown	YAGFEM...	222		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145827
Q99832-327-	GGSIQT...	327			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99832-327-unknown	GGSIQT...	327		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170566
Q99832-327-unknown	GGSIQT...	327		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170564
Q99832-327-unknown	GGSIQT...	327		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170565
Q99832-329-	SIQTSV...	329			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q99832-329-unknown	SIQTSV...	329		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176533
Q99832-329-unknown	SIQTSV...	329		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176531
Q99832-329-unknown	SIQTSV...	329		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176532
Q99832-332-unknown	TSVNAL...	332		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183204
Q99832-332-unknown	TSVNAL...	332		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183202
Q99832-332-unknown	TSVNAL...	332		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183203
Q99832-332-	TSVNAL...	332			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q99832-333-unknown	SVNALS...	333		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173412
Q99832-333-unknown	SVNALS...	333		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173410
Q99832-333-unknown	SVNALS...	333		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173411
Q99832-333-	SVNALS...	333			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99832-336-unknown	ALSADV...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170571
Q99832-336-unknown	ALSADV...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170569
Q99832-336-unknown	ALSADV...	336		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170570
Q99832-336-	ALSADV...	336			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99832-345-acetylation	CQVFEE...	345	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q99832-345-acetylation	CQVFEE...	345	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183208
Q99832-345-acetylation	CQVFEE...	345	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183206
Q99832-345-acetylation	CQVFEE...	345	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183207
Q99832-373-unknown	ILRGGA...	373		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14902
Q99832-373-unknown	ILRGGA...	373		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145488
Q99832-373-unknown	ILRGGA...	373		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149483
Q99832-373-unknown	ILRGGA...	373		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150501
Q99832-376-	GGAEQF...	376			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99832-376-unknown	GGAEQF...	376		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170562
Q99832-376-unknown	GGAEQF...	376		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170560
Q99832-376-unknown	GGAEQF...	376		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170561
Q99832-408-unknown	GGGAIE...	408		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18087
Q99832-408-unknown	GGGAIE...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146669
Q99832-408-unknown	GGGAIE...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150364
Q99832-408-unknown	GGGAIE...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151282
Q99832-409-unknown	GGAIEM...	409		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18091
Q99832-409-unknown	GGAIEM...	409		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146722
Q99832-409-unknown	GGAIEM...	409		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150393
Q99832-409-unknown	GGAIEM...	409		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151307
Q99832-451-unknown	DNAGFD...	451		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6718
Q99832-451-unknown	DNAGFD...	451		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148315
Q99832-451-unknown	DNAGFD...	451		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151271
Q99832-451-unknown	DNAGFD...	451		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152102

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKLLDV	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6713
...LKLLDV	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120269
...KPYVEE	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19754
...KPYVEE	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6715
...KPYVEE	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120265
...KPYVEE	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123748
...GGALED	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19757
...GGALED	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126696
...GGALED	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128553
...KKTFSY	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4223
...KKTFSY	221	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127328
...KKTFSY	221	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129124
...KTCTFI	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14902
...KTCTFI	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128784
...KTCTFI	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132867
...KTCTFI	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133897
...DSVVAG	407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18087
...DSVVAG	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129979
...DSVVAG	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133761
...DSVVAG	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134684
...SVVAGG	408	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18091
...SVVAGG	408	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130034
...SVVAGG	408	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133790
...SVVAGG	408	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134709
...PRQLCD	450	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6718
...PRQLCD	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131685
...PRQLCD	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134673
...PRQLCD	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135511
...RGRPH	543	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RGRPH	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87372
...RGRPH	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87374
...RGRPH	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87373

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	70	LLDV.\|.VVHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	113	YVEE.\|.EGLH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	113	YVEE.\|.EGLH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	206	ALED.\|.DSQL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	221	TFSY.\|.YAGF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	372	CTFI.\|.ILRG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	407	VVAG.\|.GGGA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	408	VAGG.\|.GGAI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	450	QLCD.\|.DNAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)