P11766: Alcohol dehydrogenase class-3

General Information

Protein names	- Alcohol dehydrogenase class-3 - 1.1.1.1 {ECO:0000269\|PubMed:8460164} - Alcohol dehydrogenase 5 - Alcohol dehydrogenase class chi chain - Alcohol dehydrogenase class-III - Glutathione-dependent formaldehyde dehydrogenase - FALDH - FDH - GSH-FDH - 1.1.1.- - S-(hydroxymethyl)glutathione dehydrogenase - 1.1.1.284 {ECO:0000269\|PubMed:8460164}
Gene names	ADH5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P11766

6 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY TLSGADPEGC
        70         80         90        100        110        120
FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC KFCLNPKTNL CQKIRVTQGK
       130        140        150        160        170        180
GLMPDGTSRF TCKGKTILHY MGTSTFSEYT VVADISVAKI DPLAPLDKVC LLGCGISTGY
       190        200        210        220        230        240
GAAVNTAKLE PGSVCAVFGL GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC
       250        260        270        280        290        300
INPQDFSKPI QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE
       310        320        330        340        350        360
IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL SFDEINKAFE
       370
LMHSGKSIRT VVKI

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P11766-2-unknown	MANEVI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11766-2-Acetylation	ANEVIK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11766-2-Acetylation	ANEVIK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P11766-5-unknown	VIKCKA...	5		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000427049
P11766-241-unknown	INPQDF...	241		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13966
P11766-348-unknown	HNLSFD...	348		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7293
P11766-348-unknown	HNLSFD...	348		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5561
P11766-353-unknown	DEINKA...	353		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18704
P11766-353-unknown	DEINKA...	353		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17320

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GATECI	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13966
...NVKVMR	275	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427049
...DEFVTH	347	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7293
...DEFVTH	347	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5561
...HNLSFD	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18704
...HNLSFD	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17320
...TVVKI	374	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	240	TECI.\|.INPQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	347	FVTH.\|.HNLS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	347	FVTH.\|.HNLS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	352	LSFD.\|.DEIN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	352	LSFD.\|.DEIN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)