Q9NQ38: Serine protease inhibitor Kazal-type 5

General Information

Protein names	- Serine protease inhibitor Kazal-type 5 - Lympho-epithelial Kazal-type-related inhibitor - LEKTI - Hemofiltrate peptide HF6478 - Hemofiltrate peptide HF7665
Gene names	SPINK5
Organism	Homo sapiens
Protease Family
Protease ID	I01.950
Chromosome location
UniProt ID	Q9NQ38

5 N-termini

4 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform short of Serine protease inhibitor Kazal-type 5 - Isoform long of Serine protease inhibitor Kazal-type 5

Sequence View

        10         20         30         40         50         60
MKIATVSVLL PLALCLIQDA ASKNEDQEMC HEFQAFMKNG KLFCPQDKKF FQSLDGIMFI
        70         80         90        100        110        120
NKCATCKMIL EKEAKSQKRA RHLARAPKAT APTELNCDDF KKGERDGDFI CPDYYEAVCG
       130        140        150        160        170        180
TDGKTYDNRC ALCAENAKTG SQIGVKSEGE CKSSNPEQDV CSAFRPFVRD GRLGCTREND
       190        200        210        220        230        240
PVLGPDGKTH GNKCAMCAEL FLKEAENAKR EGETRIRRNA EKDFCKEYEK QVRNGRLFCT
       250        260        270        280        290        300
RESDPVRGPD GRMHGNKCAL CAEIFKQRFS EENSKTDQNL GKAEEKTKVK REIVKLCSQY
       310        320        330        340        350        360
QNQAKNGILF CTRENDPIRG PDGKMHGNLC SMCQAYFQAE NEEKKKAEAR ARNKRESGKA
       370        380        390        400        410        420
TSYAELCSEY RKLVRNGKLA CTRENDPIQG PDGKVHGNTC SMCEVFFQAE EEEKKKKEGK
       430        440        450        460        470        480
SRNKRQSKST ASFEELCSEY RKSRKNGRLF CTRENDPIQG PDGKMHGNTC SMCEAFFQQE
       490        500        510        520        530        540
ERARAKAKRE AAKEICSEFR DQVRNGTLIC TREHNPVRGP DGKMHGNKCA MCASVFKLEE
       550        560        570        580        590        600
EEKKNDKEEK GKVEAEKVKR EAVQELCSEY RHYVRNGRLP CTRENDPIEG LDGKIHGNTC
       610        620        630        640        650        660
SMCEAFFQQE AKEKERAEPR AKVKREAEKE TCDEFRRLLQ NGKLFCTREN DPVRGPDGKT
       670        680        690        700        710        720
HGNKCAMCKA VFQKENEERK RKEEEDQRNA AGHGSSGGGG GNTQDECAEY REQMKNGRLS
       730        740        750        760        770        780
CTRESDPVRD ADGKSYNNQC TMCKAKLERE AERKNEYSRS RSNGTGSESG KDTCDEFRSQ
       790        800        810        820        830        840
MKNGKLICTR ESDPVRGPDG KTHGNKCTMC KEKLEREAAE KKKKEDEDRS NTGERSNTGE
       850        860        870        880        890        900
RSNDKEDLCR EFRSMQRNGK LICTRENNPV RGPYGKMHIN KCAMCQSIFD REANERKKKD
       910        920        930        940        950        960
EEKSSSKPSN NAKDECSEFR NYIRNNELIC PRENDPVHGA DGKFYTNKCY MCRAVFLTEA
       970        980        990       1000       1010       1020
LERAKLQEKP SHVRASQEED SPDSFSSLDS EMCKDYRVLP RIGYLCPKDL KPVCGDDGQT
      1030       1040       1050       1060
YNNPCMLCHE NLIRQTNTHI RSTGKCEESS TPGTTAASMP PSDE         10         20         30         40         50         60
MKIATVSVLL PLALCLIQDA ASKNEDQEMC HEFQAFMKNG KLFCPQDKKF FQSLDGIMFI
        70         80         90        100        110        120
NKCATCKMIL EKEAKSQKRA RHLARAPKAT APTELNCDDF KKGERDGDFI CPDYYEAVCG
       130        140        150        160        170        180
TDGKTYDNRC ALCAENAKTG SQIGVKSEGE CKSSNPEQDV CSAFRPFVRD GRLGCTREND
       190        200        210        220        230        240
PVLGPDGKTH GNKCAMCAEL FLKEAENAKR EGETRIRRNA EKDFCKEYEK QVRNGRLFCT
       250        260        270        280        290        300
RESDPVRGPD GRMHGNKCAL CAEIFKQRFS EENSKTDQNL GKAEEKTKVK REIVKLCSQY
       310        320        330        340        350        360
QNQAKNGILF CTRENDPIRG PDGKMHGNLC SMCQAYFQAE NEEKKKAEAR ARNKRESGKA
       370        380        390        400        410        420
TSYAELCSEY RKLVRNGKLA CTRENDPIQG PDGKVHGNTC SMCEVFFQAE EEEKKKKEGK
       430        440        450        460        470        480
SRNKRQSKST ASFEELCSEY RKSRKNGRLF CTRENDPIQG PDGKMHGNTC SMCEAFFQQE
       490        500        510        520        530        540
ERARAKAKRE AAKEICSEFR DQVRNGTLIC TREHNPVRGP DGKMHGNKCA MCASVFKLEE
       550        560        570        580        590        600
EEKKNDKEEK GKVEAEKVKR EAVQELCSEY RHYVRNGRLP CTRENDPIEG LDGKIHGNTC
       610        620        630        640        650        660
SMCEAFFQQE AKEKERAEPR AKVKREAEKE TCDEFRRLLQ NGKLFCTREN DPVRGPDGKT
       670        680        690        700        710        720
HGNKCAMCKA VFQKENEERK RKEEEDQRNA AGHGSSGGGG GNTQDECAEY REQMKNGRLS
       730        740        750        760        770        780
CTRESDPVRD ADGKSYNNQC TMCKAKLERE AERKNEYSRS RSNGTGSESG KDTCDEFRSQ
       790        800        810        820        830        840
MKNGKLICTR ESDPVRGPDG KTHGNKCTMC KEKLEREAAE KKKKEDEDRS NTGERSNTGE
       850        860        870        880        890        900
RSNDKEDLCR EFRSMQRNGK LICTRENNPV RGPYGKMHIN KCAMCQSIFD REANERKKKD
       910        920        930        940        950        960
EEKSSSKPSN NAKDECSEFR NYIRNNELIC PRENDPVHGA DGKFYTNKCY MCRAVFLTEA
       970        980        990       1000       1010       1020
LERAKLQEKP SHVRASQEED SPDSFSSLDS EMCKDYRVLP RIGYLCPKDL KPVCGDDGQT
      1030       1040       1050       1060
YNNPCMLCHE NLIRQTNTHI RSTGKCEESS TPGTTAASMP PSDE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NQ38-1-unknown	MKIATV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78098
Q9NQ38-1-unknown	MKIATV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78099
Q9NQ38-23-unknown	KNEDQE...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NQ38-23-unknown	KNEDQE...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113242
Q9NQ38-23-unknown	KNEDQE...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113243
Q9NQ38-86-unknown	APKATA...	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18130
Q9NQ38-86-unknown	APKATA...	86	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141651
Q9NQ38-86-unknown	APKATA...	86	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141653
Q9NQ38-90-unknown	TAPTEL...	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19802
Q9NQ38-90-unknown	TAPTEL...	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18133
Q9NQ38-90-unknown	TAPTEL...	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141813
Q9NQ38-90-unknown	TAPTEL...	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141814
Q9NQ38-980-unknown	DSPDSF...	980	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19805
Q9NQ38-980-unknown	DSPDSF...	980	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18136
Q9NQ38-980-unknown	DSPDSF...	980	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157172

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RHLARA	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18130
...RHLARA	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124831
...RHLARA	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124833
...RAPKAT	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19802
...RAPKAT	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18133
...RAPKAT	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124994
...RAPKAT	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124995
...ASQEED	979	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19805
...ASQEED	979	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18136
...ASQEED	979	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140673
...PPSDE	1064	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PPSDE	1064	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73717

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	85	LARA.\|.APKA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	89	PKAT.\|.TAPT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	89	PKAT.\|.TAPT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	979	QEED.\|.DSPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	979	QEED.\|.DSPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)