Q9HB71: Calcyclin-binding protein

General Information

Protein names	- Calcyclin-binding protein - CacyBP - hCacyBP - S100A6-binding protein - Siah-interacting protein
Gene names	CACYBP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9HB71

16 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Calcyclin-binding protein - Isoform 3 of Calcyclin-binding protein

Sequence View

        10         20         30         40         50         60
MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP
        70         80         90        100        110        120
AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL
       130        140        150        160        170        180
NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KECKEKEKPS
       190        200        210        220
YDTETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF         10         20         30         40         50         60
MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP
        70         80         90        100        110        120
AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL
       130        140        150        160        170        180
NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KECKEKEKPS
       190        200        210        220
YDTETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

16 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9HB71-2-unknown	MASEEL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HB71-2-unknown	MASEEL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174153
Q9HB71-1-unknown	MASEEL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72230
Q9HB71-2-	ASEELQ...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9HB71-2-Acetylation	ASEELQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HB71-2-Acetylation	ASEELQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9HB71-2-Acetylation	ASEELQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9HB71-2-Acetylation	ASEELQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9HB71-2-Acetylation	ASEELQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111035
Q9HB71-9-unknown	DLEEVK...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19798
Q9HB71-9-unknown	DLEEVK...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18127
Q9HB71-9-unknown	DLEEVK...	9		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194826
Q9HB71-44-unknown	MQQKSQ...	44		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72231
Q9HB71-44-unknown	MQQKSQ...	44		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98054
Q9HB71-51-	KAELLD...	51			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9HB71-51-	KAELLD...	51			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9HB71-51-	KAELLD...	51			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9HB71-51-unknown	KAELLD...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164512
Q9HB71-51-unknown	KAELLD...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164513
Q9HB71-63-unknown	VVAPIT...	63		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169922
Q9HB71-63-	VVAPIT...	63			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9HB71-126-	SMIVNN...	126			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9HB71-126-	SMIVNN...	126			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q9HB71-126-unknown	SMIVNN...	126			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9HB71-126-unknown	SMIVNN...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161431
Q9HB71-134-unknown	KPISVE...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6787
Q9HB71-134-unknown	KPISVE...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141894
Q9HB71-185-unknown	TDPSEG...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19799
Q9HB71-185-unknown	TDPSEG...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144402
Q9HB71-209-	TINKAW...	209			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9HB71-209-unknown	TINKAW...	209		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177253

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EELQKD	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19798
...EELQKD	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18127
...VNNLLK	133	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6787
...VNNLLK	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125072
...SYDTET	184	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19799
...SYDTET	184	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127665
...GDTEF	228		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GDTEF	228		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GDTEF	228	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GDTEF	228	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt67849
...GDTEF	228		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GDTEF	228		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	8	LQKD.\|.DLEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	8	LQKD.\|.DLEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	133	NLLK.\|.KPIS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	184	DTET.\|.TDPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)