P11586: C-1-tetrahydrofolate synthase, cytoplasmic

General Information

Protein names	- C-1-tetrahydrofolate synthase, cytoplasmic - C1-THF synthase - Methylenetetrahydrofolate dehydrogenase - 1.5.1.5 - Methenyltetrahydrofolate cyclohydrolase - 3.5.4.9 - Formyltetrahydrofolate synthetase - 6.3.4.3 - C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
Gene names	MTHFD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P11586

21 N-termini

15 C-termini

15 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA
        70         80         90        100        110        120
EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP
       130        140        150        160        170        180
EKDVDGLTSI NAGRLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP
       190        200        210        220        230        240
MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY
       250        260        270        280        290        300
VPDDKKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLEKFKP
       310        320        330        340        350        360
GKWMIQYNNL NLKTPVPSDI DISRSCKPKP IGKLAREIGL LSEEVELYGE TKAKVLLSAL
       370        380        390        400        410        420
ERLKHRPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGAH LYQNVFACVR QPSQGPTFGI
       430        440        450        460        470        480
KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARIFHELTQ TDKALFNRLV
       490        500        510        520        530        540
PSVNGVRRFS DIQIRRLKRL GIEKTDPTTL TDEEINRFAR LDIDPETITW QRVLDTNDRF
       550        560        570        580        590        600
LRKITIGQAP TEKGHTRTAQ FDISVASEIM AVLALTTSLE DMRERLGKMV VASSKKGEPV
       610        620        630        640        650        660
SAEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG
       670        680        690        700        710        720
PEGFVVTEAG FGADIGMEKF FNIKCRYSGL CPHVVVLVAT VRALKMHGGG PTVTAGLPLP
       730        740        750        760        770        780
KAYIQENLEL VEKGFSNLKK QIENARMFGI PVVVAVNAFK TDTESELDLI SRLSREHGAF
       790        800        810        820        830        840
DAVKCTHWAE GGKGALALAQ AVQRAAQAPS SFQLLYDLKL PVEDKIRIIA QKIYGADDIE
       850        860        870        880        890        900
LLPEAQHKAE VYTKQGFGNL PICMAKTHLS LSHNPEQKGV PTGFILPIRD IRASVGAGFL
       910        920        930
YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

21 N-termini - 15 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P11586-1-Acetylation	MAPAEI...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11586-1-Acetylation	MAPAEI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P11586-1-Acetylation	MAPAEI...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P11586-1-Acetylation	MAPAEI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P11586-2-Acetylation	MAPAEI...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11586-2-unknown	APAEIL...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11586-2-unknown	APAEIL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P11586-2-unknown	APAEIL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P11586-2-	APAEIL...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P11586-2-	APAEIL...	2			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P11586-61-unknown	EEIGIK...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18700
P11586-61-unknown	EEIGIK...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17318
P11586-82-unknown	MKYITS...	82		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000477359
P11586-82-unknown	MKYITS...	82		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000477501
P11586-82-unknown	MKYITS...	82		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000476468
P11586-108-	SINTEE...	108			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P11586-108-	SINTEE...	108			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P11586-108-	SINTEE...	108			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P11586-117-	AIAPEK...	117			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P11586-117-	AIAPEK...	117			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P11586-117-	AIAPEK...	117			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P11586-142-unknown	DCFIPC...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18701
P11586-206-unknown	VNKGDI...	206		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18702
P11586-256-unknown	VAYDEA...	256		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11189
P11586-268-unknown	ITPVPG...	268		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7289
P11586-629-	GTPVFV...	629			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P11586-641-unknown	NIAHGN...	641		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7290
P11586-644-unknown	HGNSSI...	644		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7291
P11586-644-unknown	HGNSSI...	644		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5559
P11586-713-unknown	VTAGLP...	713		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3619
P11586-816-unknown	YDLKLP...	816		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000477199
P11586-836-unknown	ADDIEL...	836		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5560
P11586-838-unknown	DIELLP...	838		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11190
P11586-839-unknown	IELLPE...	839		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18703
P11586-839-unknown	IELLPE...	839		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17319
P11586-870-unknown	SLSHNP...	870		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3620

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLKAAE	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18700
...KLKAAE	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17318
...QLPLDS	104	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000477359
...PLDSEN	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000477501
...RGDLND	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18701
...AHLDEE	204	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450560
...AHLDEE	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18702
...KVVGDV	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11189
...ERASFI	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7289
...AGPFAN	640	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7290
...FANIAH	643	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7291
...FANIAH	643	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5559
...GGGPTV	712	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3619
...QKIYGA	835	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5560
...IYGADD	837	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11190
...YGADDI	838	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18703
...YGADDI	838	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17319
...AKTHLS	869	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3620
...VNGLF	935	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	60	KAAE.\|.EEIG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	60	KAAE.\|.EEIG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	141	DLND.\|.DCFI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	205	DEEV.\|.VNKG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	255	VGDV.\|.VAYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	267	ASFI.\|.ITPV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	640	PFAN.\|.NIAH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	643	NIAH.\|.HGNS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	643	NIAH.\|.HGNS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	712	GPTV.\|.VTAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	835	IYGA.\|.ADDI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	837	GADD.\|.DIEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	838	ADDI.\|.IELL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	838	ADDI.\|.IELL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	869	THLS.\|.SLSH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)