P31939: Bifunctional purine biosynthesis protein PURH

General Information

Protein names	- Bifunctional purine biosynthesis protein PURH - Phosphoribosylaminoimidazolecarboxamide formyltransferase - 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase - AICAR transformylase - IMP cyclohydrolase - 3.5.4.10 - ATIC - IMP synthase - Inosinicase - Bifunctional purine biosynthesis protein PURH, N-terminally processed
Gene names	ATIC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P31939

23 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPGQLALFS VSDKTGLVEF ARNLTALGLN LVASGGTAKA LRDAGLAVRD VSELTGFPEM
        70         80         90        100        110        120
LGGRVKTLHP AVHAGILARN IPEDNADMAR LDFNLIRVVA CNLYPFVKTV ASPGVTVEEA
       130        140        150        160        170        180
VEQIDIGGVT LLRAAAKNHA RVTVVCEPED YVVVSTEMQS SESKDTSLET RRQLALKAFT
       190        200        210        220        230        240
HTAQYDEAIS DYFRKQYSKG VSQMPLRYGM NPHQTPAQLY TLQPKLPITV LNGAPGFINL
       250        260        270        280        290        300
CDALNAWQLV KELKEALGIP AAASFKHVSP AGAAVGIPLS EDEAKVCMVY DLYKTLTPIS
       310        320        330        340        350        360
AAYARARGAD RMSSFGDFVA LSDVCDVPTA KIISREVSDG IIAPGYEEEA LTILSKKKNG
       370        380        390        400        410        420
NYCVLQMDQS YKPDENEVRT LFGLHLSQKR NNGVVDKSLF SNVVTKNKDL PESALRDLIV
       430        440        450        460        470        480
ATIAVKYTQS NSVCYAKNGQ VIGIGAGQQS RIHCTRLAGD KANYWWLRHH PQVLSMKFKT
       490        500        510        520        530        540
GVKRAEISNA IDQYVTGTIG EDEDLIKWKA LFEEVPELLT EAEKKEWVEK LTEVSISSDA
       550        560        570        580        590
FFPFRDNVDR AKRSGVAYIA APSGSAADKV VIEACDELGI ILAHTNLRLF HH

Isoforms

- Isoform 2 of Bifunctional purine biosynthesis protein PURH

Sequence View

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Protein Neighborhood

Domains & Features

23 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P31939-1-Acetylation	MAPGQL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31939-1-Acetylation	MAPGQL...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P31939-1-Acetylation	MAPGQL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P31939-1-	MAPGQL...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31939-1-	MAPGQL...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31939-2-	APGQLA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31939-2-unknown	APGQLA...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P31939-2-unknown	APGQLA...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P31939-2-unknown	APGQLA...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31939-2-unmodified	APGQLA...	2			other		CNRS/ISV	Large_scale_NTA_Human
P31939-4-	GQLALF...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31939-4-	GQLALF...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31939-4-	GQLALF...	4			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31939-4-	GQLALF...	4			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31939-4-	GQLALF...	4			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31939-13-unknown	DKTGLV...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19036
P31939-13-unknown	DKTGLV...	13		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194982
P31939-34-unknown	SGGTAK...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5787
P31939-34-unknown	SGGTAK...	34		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137825
P31939-80-unknown	NIPEDN...	80		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170633
P31939-80-	NIPEDN...	80			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31939-80-	NIPEDN...	80			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31939-209-	GMNPHQ...	209			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31939-209-unknown	GMNPHQ...	209		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177773
P31939-267-	HVSPAG...	267			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31939-267-	HVSPAG...	267			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31939-267-unknown	HVSPAG...	267		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173678
P31939-267-unknown	HVSPAG...	267		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31939-340-	GIIAPG...	340			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31939-340-	GIIAPG...	340			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P31939-340-	GIIAPG...	340			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31939-340-unknown	GIIAPG...	340		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175423
P31939-369-unknown	QSYKPD...	369		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7427
P31939-369-unknown	QSYKPD...	369		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151359
P31939-371-unknown	YKPDEN...	371		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17573
P31939-371-unknown	YKPDEN...	371		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151416
P31939-432-unknown	SVCYAK...	432		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176503
P31939-432-	SVCYAK...	432			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P31939-439-unknown	GQVIGI...	439		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176505
P31939-439-	GQVIGI...	439			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P31939-514-unknown	EVPELL...	514		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17575
P31939-514-unknown	EVPELL...	514		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153570

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFSVSD	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19036
...LNLVAS	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5787
...LNLVAS	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120826
...VLQMDQ	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7427
...VLQMDQ	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134761
...QMDQSY	370	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17573
...QMDQSY	370	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134819
...KALFEE	513	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17575
...KALFEE	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136992
...RLFHH	592	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RLFHH	592	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82293

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	12	SVSD.\|.DKTG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	33	LVAS.\|.SGGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	368	QMDQ.\|.QSYK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	370	DQSY.\|.YKPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	513	LFEE.\|.EVPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)