P0C0S5: Histone H2A.Z

General Information

Protein names	- Histone H2A.Z - H2A/z
Gene names	H2AFZ
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P0C0S5

10 N-termini

9 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE
        70         80         90        100        110        120
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG

KKGQQKTV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 9 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P0C0S5-2-unknown	MAGGKA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P0C0S5-2-unknown	MAGGKA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P0C0S5-2-unknown	MAGGKA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P0C0S5-2-Acetylation	AGGKAG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P0C0S5-6-unknown	AGKDSG...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9961
P0C0S5-9-unknown	DSGKAK...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9962
P0C0S5-10-unknown	SGKAKT...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11161
P0C0S5-24-unknown	AGLQFP...	24		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9963
P0C0S5-63-unknown	TAEVLE...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13950
P0C0S5-65-unknown	EVLELA...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18636
P0C0S5-86-unknown	HLQLAI...	86		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9964
P0C0S5-103-unknown	ATIAGG...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5529

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MAGGKA	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9961
...GKAGKD	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9962
...KAGKDS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11161
...SRSQRA	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9963
...ILEYLT	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13950
...EYLTAE	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18636
...RITPRH	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9964
...DSLIKA	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5529
...QQKTV	128	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	5	GGKA.\|.AGKD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	8	AGKD.\|.DSGK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	9	GKDS.\|.SGKA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	23	SQRA.\|.AGLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	62	EYLT.\|.TAEV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	64	LTAE.\|.EVLE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAA_HUMAN	85	TPRH.\|.HLQL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	102	LIKA.\|.ATIA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)