P02545: Prelamin-A/C

General Information

Protein names	- Prelamin-A/C - Lamin-A/C - 70 kDa lamin - Renal carcinoma antigen NY-REN-32
Gene names	LMNA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02545

10 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform C of Prelamin-A/C - Isoform ADelta10 of Prelamin-A/C - Isoform 4 of Prelamin-A/C - Isoform 5 of Prelamin-A/C - Isoform 6 of Prelamin-A/C

Sequence View

        10         20         30         40         50         60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
        70         80         90        100        110        120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
       130        140        150        160        170        180
TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
       190        200        210        220        230        240
KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
       250        260        270        280        290        300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
       310        320        330        340        350        360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
       370        380        390        400        410        420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQTQ GGGSVTKKRK
       430        440        450        460        470        480
LESTESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT
       490        500        510        520        530        540
YRFPPKFTLK AGQVVTIWAA GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEEVAM
       550        560        570        580        590        600
RKLVRSVTVV EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA
       610        620        630        640        650        660
SGSGAQVGGP ISSGSSASSV TVTRSYRSVG GSGGGSFGDN LVTRSYLLGN SSPRTQSPQN

CSIM         10         20         30         40         50         60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
        70         80         90        100        110        120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
       130        140        150        160        170        180
TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
       190        200        210        220        230        240
KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
       250        260        270        280        290        300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
       310        320        330        340        350        360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
       370        380        390        400        410        420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQTQ GGGSVTKKRK
       430        440        450        460        470        480
LESTESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT
       490        500        510        520        530        540
YRFPPKFTLK AGQVVTIWAA GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEEVAM
       550        560        570        580        590        600
RKLVRSVTVV EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA
       610        620        630        640        650        660
SGSGAQVGGP ISSGSSASSV TVTRSYRSVG GSGGGSFGDN LVTRSYLLGN SSPRTQSPQN

CSIM         10         20         30         40         50         60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
        70         80         90        100        110        120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
       130        140        150        160        170        180
TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
       190        200        210        220        230        240
KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
       250        260        270        280        290        300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
       310        320        330        340        350        360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
       370        380        390        400        410        420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQTQ GGGSVTKKRK
       430        440        450        460        470        480
LESTESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT
       490        500        510        520        530        540
YRFPPKFTLK AGQVVTIWAA GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEEVAM
       550        560        570        580        590        600
RKLVRSVTVV EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA
       610        620        630        640        650        660
SGSGAQVGGP ISSGSSASSV TVTRSYRSVG GSGGGSFGDN LVTRSYLLGN SSPRTQSPQN

CSIM         10         20         30         40         50         60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
        70         80         90        100        110        120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
       130        140        150        160        170        180
TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
       190        200        210        220        230        240
KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
       250        260        270        280        290        300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
       310        320        330        340        350        360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
       370        380        390        400        410        420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQTQ GGGSVTKKRK
       430        440        450        460        470        480
LESTESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT
       490        500        510        520        530        540
YRFPPKFTLK AGQVVTIWAA GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEEVAM
       550        560        570        580        590        600
RKLVRSVTVV EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA
       610        620        630        640        650        660
SGSGAQVGGP ISSGSSASSV TVTRSYRSVG GSGGGSFGDN LVTRSYLLGN SSPRTQSPQN

CSIM         10         20         30         40         50         60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
        70         80         90        100        110        120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
       130        140        150        160        170        180
TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
       190        200        210        220        230        240
KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
       250        260        270        280        290        300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
       310        320        330        340        350        360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
       370        380        390        400        410        420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQTQ GGGSVTKKRK
       430        440        450        460        470        480
LESTESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT
       490        500        510        520        530        540
YRFPPKFTLK AGQVVTIWAA GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEEVAM
       550        560        570        580        590        600
RKLVRSVTVV EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA
       610        620        630        640        650        660
SGSGAQVGGP ISSGSSASSV TVTRSYRSVG GSGGGSFGDN LVTRSYLLGN SSPRTQSPQN

CSIM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P02545-1-Acetylation	METPSQ...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02545-1-Acetylation	METPSQ...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P02545-1-Acetylation	METPSQ...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P02545-1-Acetylation	METPSQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101163
P02545-1-Acetylation	METPSQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101164
P02545-1-Acetylation	METPSQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101165
P02545-1-unknown	METPSQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79737
P02545-1-unknown	METPSQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79738
P02545-1-unknown	METPSQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79741
P02545-31-unknown	EKEDLQ...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17029
P02545-31-unknown	EKEDLQ...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18371
P02545-31-unknown	EKEDLQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137631
P02545-31-unknown	EKEDLQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137632
P02545-31-unknown	EKEDLQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137635
P02545-231-unknown	NGKQRE...	231		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2425
P02545-231-unknown	NGKQRE...	231		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143427
P02545-231-unknown	NGKQRE...	231		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143969
P02545-231-unknown	NGKQRE...	231		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147765
P02545-231-unknown	NGKQRE...	231		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147767
P02545-231-unknown	NGKQRE...	231		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147768
P02545-253-unknown	EDQVEQ...	253		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17033
P02545-253-unknown	EDQVEQ...	253		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18375
P02545-253-unknown	EDQVEQ...	253		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144355
P02545-253-unknown	EDQVEQ...	253		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144903
P02545-253-unknown	EDQVEQ...	253		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148538
P02545-253-unknown	EDQVEQ...	253		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148539
P02545-253-unknown	EDQVEQ...	253		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148540
P02545-254-unknown	DQVEQY...	254		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17039
P02545-254-unknown	DQVEQY...	254		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18381
P02545-254-unknown	DQVEQY...	254		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144411
P02545-254-unknown	DQVEQY...	254		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144950
P02545-254-unknown	DQVEQY...	254		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148595
P02545-254-unknown	DQVEQY...	254		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148597
P02545-254-unknown	DQVEQY...	254		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148598
P02545-287-	AAHEEL...	287			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P02545-287-unknown	AAHEEL...	287		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178532
P02545-287-unknown	AAHEEL...	287		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178531
P02545-287-unknown	AAHEEL...	287		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178530
P02545-287-unknown	AAHEEL...	287		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178533
P02545-287-unknown	AAHEEL...	287		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178534
P02545-375-unknown	AYRKLL...	375		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424977
P02545-375-unknown	AYRKLL...	375		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199224
P02545-375-unknown	AYRKLL...	375		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199223
P02545-375-unknown	AYRKLL...	375		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199222
P02545-375-unknown	AYRKLL...	375		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199225
P02545-375-unknown	AYRKLL...	375		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199226
P02545-647-unknown	LLGNSS...	647		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9650
P02545-647-unknown	LLGNSS...	647		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153974
P02545-647-unknown	LLGNSS...	647		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154882

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ITRLQE	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17029
...ITRLQE	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18371
...ITRLQE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120626
...ITRLQE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120627
...ITRLQE	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120630
...LVEIDN	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2425
...LVEIDN	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126660
...LVEIDN	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127212
...LVEIDN	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131120
...LVEIDN	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131122
...LVEIDN	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131123
...LRAQHE	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17033
...LRAQHE	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18375
...LRAQHE	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127617
...LRAQHE	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128180
...LRAQHE	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131912
...LRAQHE	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131913
...LRAQHE	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131914
...RAQHED	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17039
...RAQHED	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18381
...RAQHED	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127675
...RAQHED	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128226
...RAQHED	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131969
...RAQHED	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131971
...RAQHED	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131972
...KELEKT	265	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426535
...VTRSYL	646	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VTRSYL	646	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9650
...VTRSYL	646	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93179
...VTRSYL	646	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93178
...VTRSYL	646	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93180
...SPQNCS methylation-	661	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SPQNCS methylation-	661	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93193
...SPQNCS methylation-	661	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93192
...SPQNCS methylation-	661	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93194
...NCSIM	664	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75358
...NCSIM	664	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75356

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	30	RLQE.\|.EKED	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	30	RLQE.\|.EKED	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP6_HUMAN	230	EIDN.\|.NGKQ	inferred from experiment	unknown	MEROPS	Pervaiz S	Lee SC et al.:Functional proteomics of resver... (C14.005)	16518869,
MEP1A_HUMAN	252	AQHE.\|.EDQV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	252	AQHE.\|.EDQV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	253	QHED.\|.DQVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	253	QHED.\|.DQVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
FACE1_HUMAN	646	RSYL.\|.LLGN	inferred from experiment	unknown	MEROPS	Sinensky MS	Corrigan DP et al.:Prelamin A endoproteolytic proc... (M48.003)	15479156,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)