P42704: Leucine-rich PPR motif-containing protein, mitochondrial
Protein names | - Leucine-rich PPR motif-containing protein, mitochondrial - 130 kDa leucine-rich protein - LRP 130 - GP130 |
---|---|
Gene names | LRPPRC |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P42704 |
8
N-termini
4
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAALLRSARW LLRAGAAPRL PLSLRLLPGG PGRLHAASYL PAARAGPVAG GLLSPARLYA
70 80 90 100 110 120
IAAKEKDIQE ESTFSSRKIS NQFDWALMRL DLSVRRTGRI PKKLLQKVFN DTCRSGGLGG
130 140 150 160 170 180
SHALLLLRSC GSLLPELKLE ERTEFAHRIW DTLQKLGAVY DVSHYNALLK VYLQNEYKFS
190 200 210 220 230 240
PTDFLAKMEE ANIQPNRVTY QRLIASYCNV GDIEGASKIL GFMKTKDLPV TEAVFSALVT
250 260 270 280 290 300
GHARAGDMEN AENILTVMRD AGIEPGPDTY LALLNAYAEK GDIDHVKQTL EKVEKSELHL
310 320 330 340 350 360
MDRDLLQIIF SFSKAGYPQY VSEILEKVTC ERRYIPDAMN LILLLVTEKL EDVALQILLA
370 380 390 400 410 420
CPVSKEDGPS VFGSFFLQHC VTMNTPVEKL TDYCKKLKEV QMHSFPLQFT LHCALLANKT
430 440 450 460 470 480
DLAKALMKAV KEEGFPIRPH YFWPLLVGRR KEKNVQGIIE ILKGMQELGV HPDQETYTDY
490 500 510 520 530 540
VIPCFDSVNS ARAILQENGC LSDSDMFSQA GLRSEAANGN LDFVLSFLKS NTLPISLQSI
550 560 570 580 590 600
RSSLLLGFRR SMNINLWSEI TELLYKDGRY CQEPRGPTEA VGYFLYNLID SMSDSEVQAK
610 620 630 640 650 660
EEHLRQYFHQ LEKMNVKIPE NIYRGIRNLL ESYHVPELIK DAHLLVESKN LDFQKTVQLT
670 680 690 700 710 720
SSELESTLET LKAENQPIRD VLKQLILVLC SEENMQKALE LKAKYESDMV TGGYAALINL
730 740 750 760 770 780
CCRHDKVEDA LNLKEEFDRL DSSAVLDTGK YVGLVRVLAK HGKLQDAINI LKEMKEKDVL
790 800 810 820 830 840
IKDTTALSFF HMLNGAALRG EIETVKQLHE AIVTLGLAEP STNISFPLVT VHLEKGDLST
850 860 870 880 890 900
ALEVAIDCYE KYKVLPRIHD VLCKLVEKGE TDLIQKAMDF VSQEQGEMVM LYDLFFAFLQ
910 920 930 940 950 960
TGNYKEAKKI IETPGIRARS ARLQWFCDRC VANNQVETLE KLVELTQKLF ECDRDQMYYN
970 980 990 1000 1010 1020
LLKLYKINGD WQRADAVWNK IQEENVIPRE KTLRLLAEIL REGNQEVPFD VPELWYEDEK
1030 1040 1050 1060 1070 1080
HSLNSSSAST TEPDFQKDIL IACRLNQKKG AYDIFLNAKE QNIVFNAETY SNLIKLLMSE
1090 1100 1110 1120 1130 1140
DYFTQAMEVK AFAETHIKGF TLNDAANSRL IITQVRRDYL KEAVTTLKTV LDQQQTPSRL
1150 1160 1170 1180 1190 1200
AVTRVIQALA MKGDVENIEV VQKMLNGLED SIGLSKMVFI NNIALAQIKN NNIDAAIENI
1210 1220 1230 1240 1250 1260
ENMLTSENKV IEPQYFGLAY LFRKVIEEQL EPAVEKISIM AERLANQFAI YKPVTDFFLQ
1270 1280 1290 1300 1310 1320
LVDAGKVDDA RALLQRCGAI AEQTPILLLF LLRNSRKQGK ASTVKSVLEL IPELNEKEEA
1330 1340 1350 1360 1370 1380
YNSLMKSYVS EKDVTSAKAL YEHLTAKNTK LDDLFLKRYA SLLKYAGEPV PFIEPPESFE
1390
FYAQQLRKLR ENSS
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P42704-60-unknown | AIAAKE... | 60 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P42704-60-unknown | AIAAKE... | 60 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P42704-60-unknown | AIAAKE... | 60 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P42704-60- | AIAAKE... | 60 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P42704-60- | AIAAKE... | 60 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P42704-60- | AIAAKE... | 60 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P42704-60- | AIAAKE... | 60 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P42704-60- | AIAAKE... | 60 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P42704-60- | AIAAKE... | 60 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P42704-60- | AIAAKE... | 60 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P42704-62- | AAKEKD... | 62 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P42704-251-unknown | AENILT... | 251 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19103 | |||
P42704-742- | SSAVLD... | 742 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P42704-1024-unknown | NSSSAS... | 1024 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14126 | |||
P42704-1091- | AFAETH... | 1091 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P42704-1254-unknown | VTDFFL... | 1254 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000414207 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GDMENA | 250 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19103 | |||
...VTMNTP | 385 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000403637 | |||
...EKHSLN | 1023 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14126 | |||
...RENSS | 1394 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1B_HUMAN | 250 | MENA.|.AENI | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
GRAM_HUMAN | 1023 | HSLN.|.NSSS | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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