Q13185: Chromobox protein homolog 3

General Information

Protein names	- Chromobox protein homolog 3 - HECH - Heterochromatin protein 1 homolog gamma - HP1 gamma - Modifier 2 protein
Gene names	CBX3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13185

11 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASNKTTLQK MGKKQNGKSK KVEEAEPEEF VVEKVLDRRV VNGKVEYFLK WKGFTDADNT
        70         80         90        100        110        120
WEPEENLDCP ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA ADKPRGFARG
       130        140        150        160        170        180
LDPERIIGAT DSSGELMFLM KWKDSDEADL VLAKEANMKC PQIVIAFYEE RLTWHSCPED

EAQ

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13185-2-unknown	MASNKT...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q13185-2-unknown	MASNKT...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13185-2-unknown	MASNKT...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13185-2-unknown	MASNKT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13185-2-Acetylation	ASNKTT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13185-2-Acetylation	ASNKTT...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q13185-6-	TTLQKM...	6			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13185-6-	TTLQKM...	6			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13185-9-unknown	QKMGKK...	9		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000473748
Q13185-19-	SKKVEE...	19			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13185-19-	SKKVEE...	19			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q13185-19-	SKKVEE...	19			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13185-19-unknown	SKKVEE...	19			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13185-21-unknown	KVEEAE...	21			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13185-21-	KVEEAE...	21			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13185-25-unknown	AEPEEF...	25		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19408
Q13185-25-unknown	AEPEEF...	25		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17885
Q13185-68-unknown	DCPELI...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19409
Q13185-92-	KSLSDS...	92			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KKVEEA	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19408
...KKVEEA	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17885
...DNTWEP	62	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408672
...PEENLD	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19409
...EDEAQ	183	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	24	VEEA.\|.AEPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	24	VEEA.\|.AEPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	67	ENLD.\|.DCPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)