P41091: Eukaryotic translation initiation factor 2 subunit 3

General Information

Protein names	- Eukaryotic translation initiation factor 2 subunit 3 - Eukaryotic translation initiation factor 2 subunit gamma X - eIF-2-gamma X - eIF-2gX
Gene names	EIF2S3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P41091

7 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGGEAGVTL GQPHLSRQDL TTLDVTKLTP LSHEVISRQA TINIGTIGHV AHGKSTVVKA
        70         80         90        100        110        120
ISGVHTVRFK NELERNITIK LGYANAKIYK LDDPSCPRPE CYRSCGSSTP DEFPTDIPGT
       130        140        150        160        170        180
KGNFKLVRHV SFVDCPGHDI LMATMLNGAA VMDAALLLIA GNESCPQPQT SEHLAAIEIM
       190        200        210        220        230        240
KLKHILILQN KIDLVKESQA KEQYEQILAF VQGTVAEGAP IIPISAQLKY NIEVVCEYIV
       250        260        270        280        290        300
KKIPVPPRDF TSEPRLIVIR SFDVNKPGCE VDDLKGGVAG GSILKGVLKV GQEIEVRPGI
       310        320        330        340        350        360
VSKDSEGKLM CKPIFSKIVS LFAEHNDLQY AAPGGLIGVG TKIDPTLCRA DRMVGQVLGA
       370        380        390        400        410        420
VGALPEIFTE LEISYFLLRR LLGVRTEGDK KAAKVQKLSK NEVLMVNIGS LSTGGRVSAV
       430        440        450        460        470
KADLGKIVLT NPVCTEVGEK IALSRRVEKH WRLIGWGQIR RGVTIKPTVD DD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P41091-2-unknown	MAGGEA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P41091-2-unknown	MAGGEA...	1			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P41091-2-	AGGEAG...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P41091-2-	AGGEAG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P41091-2-	AGGEAG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P41091-2-	AGGEAG...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P41091-2-Acetylation	AGGEAG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P41091-2-Acetylation	AGGEAG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P41091-2-Acetylation	AGGEAG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P41091-13-unknown	PHLSRQ...	13		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P41091-273-unknown	DLKGGV...	273		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19099
P41091-273-unknown	DLKGGV...	273		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17640
P41091-294-unknown	IEVRPG...	294		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17641
P41091-332-unknown	APGGLI...	332		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19100
P41091-332-unknown	APGGLI...	332		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17642

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...GCEVDD	272	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19099
...GCEVDD	272	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17640
...KVGQEI	293	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17641
...DLQYAA	331	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19100
...DLQYAA	331	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17642
...TVDDD	472		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TVDDD	472		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...TVDDD	472	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TVDDD	472		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TVDDD	472		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	272	EVDD.\|.DLKG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	272	EVDD.\|.DLKG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	293	GQEI.\|.IEVR	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	331	QYAA.\|.APGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	331	QYAA.\|.APGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)