P06748: Nucleophosmin

General Information

Protein names	- Nucleophosmin - NPM - Nucleolar phosphoprotein B23 - Nucleolar protein NO38 - Numatrin
Gene names	NPM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06748

38 N-termini

10 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nucleophosmin - Isoform 3 of Nucleophosmin

Sequence View

        10         20         30         40         50         60
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV
        70         80         90        100        110        120
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE
       130        140        150        160        170        180
EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD
       190        200        210        220        230        240
FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG
       250        260        270        280        290
PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL         10         20         30         40         50         60
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV
        70         80         90        100        110        120
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE
       130        140        150        160        170        180
EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD
       190        200        210        220        230        240
FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG
       250        260        270        280        290
PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

38 N-termini - 10 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06748-1-Acetylation	MEDSMD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06748-1-Acetylation	MEDSMD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P06748-1-Acetylation	MEDSMD...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P06748-1-Acetylation	MEDSMD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P06748-1-Acetylation	MEDSMD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96771
P06748-1-Acetylation	MEDSMD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96772
P06748-1-unknown	MEDSMD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83140
P06748-1-unknown	MEDSMD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83141
P06748-5-acetylation	MDMDMS...	5	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P06748-5-acetylation	MDMDMS...	5	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163228
P06748-5-acetylation	MDMDMS...	5	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163229
P06748-47-	VSLGAG...	47			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06748-47-unknown	VSLGAG...	47		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176754
P06748-47-unknown	VSLGAG...	47		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176755
P06748-48-	SLGAGA...	48			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06748-48-	SLGAGA...	48			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06748-48-	SLGAGA...	48			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06748-48-	SLGAGA...	48			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06748-48-	SLGAGA...	48			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06748-48-unknown	SLGAGA...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166797
P06748-48-unknown	SLGAGA...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166798
P06748-62-unknown	AEAMNY...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5429
P06748-62-unknown	AEAMNY...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140079
P06748-62-unknown	AEAMNY...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140080
P06748-66-unknown	NYEGSP...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170353
P06748-66-unknown	NYEGSP...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170354
P06748-66-	NYEGSP...	66			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06748-82-unknown	SVQPTV...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166794
P06748-82-unknown	SVQPTV...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166795
P06748-82-	SVQPTV...	82			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06748-82-	SVQPTV...	82			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06748-82-	SVQPTV...	82			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06748-82-	SVQPTV...	82			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06748-88-unknown	SLGGFE...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168675
P06748-88-unknown	SLGGFE...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168676
P06748-88-	SLGGFE...	88			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P06748-90-	GGFEIT...	90			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06748-90-unknown	GGFEIT...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173165
P06748-90-unknown	GGFEIT...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173166
P06748-91-unknown	GFEITP...	91		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176603
P06748-91-unknown	GFEITP...	91		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176604
P06748-91-	GFEITP...	91			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P06748-130-unknown	EEDVKL...	130		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18535
P06748-130-unknown	EEDVKL...	130		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143893
P06748-130-unknown	EEDVKL...	130		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143894
P06748-131-unknown	EDVKLL...	131		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18538
P06748-131-unknown	EDVKLL...	131		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143937
P06748-131-unknown	EDVKLL...	131		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143938
P06748-143-unknown	SAPGGG...	143			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06748-143-unknown	SAPGGG...	143		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161884
P06748-143-unknown	SAPGGG...	143		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161885
P06748-143-	SAPGGG...	143			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06748-143-	SAPGGG...	143			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P06748-143-	SAPGGG...	143			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P06748-143-	SAPGGG...	143			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P06748-143-	SAPGGG...	143			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06748-143-	SAPGGG...	143			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06748-159-unknown	AADEDD...	159		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13919
P06748-159-unknown	AADEDD...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145097
P06748-159-unknown	AADEDD...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145098
P06748-162-unknown	EDDDDD...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11082
P06748-162-unknown	EDDDDD...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145213
P06748-162-unknown	EDDDDD...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145214
P06748-185-unknown	EAEEKA...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18541
P06748-185-unknown	EAEEKA...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146067
P06748-195-	SIRDTP...	195			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06748-195-unknown	SIRDTP...	195		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172545
P06748-206-unknown	KSNQNG...	206		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13922
P06748-206-unknown	KSNQNG...	206		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146756
P06748-207-unknown	SNQNGK...	207		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9938
P06748-207-unknown	SNQNGK...	207		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146808
P06748-234-unknown	TPKTPK...	234		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13924
P06748-234-unknown	TPKTPK...	234		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146712
P06748-234-unknown	TPKTPK...	234		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147876
P06748-240-	GPSSVE...	240			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P06748-240-unknown	GPSSVE...	240		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169757
P06748-251-	MQASIE...	251			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P06748-251-	MQASIE...	251			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06748-251-unknown	MQASIE...	251		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169755
P06748-264-unknown	VEAKFI...	264		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165863
P06748-264-	VEAKFI...	264			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P06748-264-	VEAKFI...	264			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P06748-269-	INYVKN...	269			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06748-269-unknown	INYVKN...	269		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175493

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LHIVEA	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5429
...LHIVEA	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123186
...LHIVEA	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123187
...SEDEEE	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18535
...SEDEEE	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127137
...SEDEEE	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127138
...EDEEEE	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18538
...EDEEEE	130	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127180
...EDEEEE	130	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127181
...KKVKLA	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13919
...KKVKLA	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128379
...KKVKLA	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128380
...KLAADE	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11082
...KLAADE	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128502
...KLAADE	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128503
...DFDDEE	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18541
...DFDDEE	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129367
...DFDDEE	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129368
...AKNAQK	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13922
...AKNAQK	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130067
...KNAQKS	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9938
...KNAQKS	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130131
...KKQEKT	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13924
...KKQEKT	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131233
...WRKSL	294	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WRKSL	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78758

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	61	IVEA.\|.AEAM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	129	DEEE.\|.EEDV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	130	EEEE.\|.EDVK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	158	VKLA.\|.AADE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	161	AADE.\|.EDDD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	184	DDEE.\|.EAEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	205	NAQK.\|.KSNQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	206	AQKS.\|.SNQN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	233	QEKT.\|.TPKT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)