P37802: Transgelin-2

General Information

Protein names	- Transgelin-2 - Epididymis tissue protein Li 7e - SM22-alpha homolog
Gene names	TAGLN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P37802

12 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE NFQNWLKDGT
        70         80         90        100        110        120
VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK
       130        140        150        160        170        180
NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT
       190
NRGASQAGMT GYGMPRQIL

Isoforms

- Isoform 2 of Transgelin-2

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P37802-2-unknown	MANRGP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P37802-2-Acetylation	ANRGPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P37802-68-unknown	ALYPEG...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7449
P37802-68-unknown	ALYPEG...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5827
P37802-69-unknown	LYPEGQ...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17621
P37802-104-	GINTTD...	104			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P37802-140-unknown	DDGLFS...	140		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19084
P37802-140-unknown	DDGLFS...	140		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17622
P37802-142-	GLFSGD...	142			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P37802-145-unknown	SGDPNW...	145		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7450
P37802-161-	NFSDNQ...	161			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P37802-161-	NFSDNQ...	161			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P37802-161-	NFSDNQ...	161			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P37802-164-unknown	DNQLQE...	164		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19085
P37802-169-unknown	EGKNVI...	169		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19086
P37802-169-unknown	EGKNVI...	169		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17623
P37802-179-	GTNRGA...	179			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P37802-179-	GTNRGA...	179			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CELINA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7449
...CELINA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5827
...ELINAL	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17621
...LAVARD	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19084
...LAVARD	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17622
...DDGLFS	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7450
...PRNFSD	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19085
...DNQLQE	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19086
...DNQLQE	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17623
...GASQAG	187	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412429
...PRQIL	199	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	67	LINA.\|.ALYP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	67	LINA.\|.ALYP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	68	INAL.\|.LYPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	139	VARD.\|.DDGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	139	VARD.\|.DDGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	144	GLFS.\|.SGDP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	163	NFSD.\|.DNQL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	168	QLQE.\|.EGKN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	168	QLQE.\|.EGKN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)