Q9NYQ8: Protocadherin Fat 2

General Information

Protein names	- Protocadherin Fat 2 - hFat2 - Cadherin family member 8 - Multiple epidermal growth factor-like domains protein 1 - Multiple EGF-like domains protein 1
Gene names	FAT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NYQ8

4 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTIALLGFAI FLLHCATCEK PLEGILSSSA WHFTHSHYNA TIYENSSPKT YVESFEKMGI
        70         80         90        100        110        120
YLAEPQWAVR YRIISGDVAN VFKTEEYVVG NFCFLRIRTK SSNTALLNRE VRDSYTLIIQ
       130        140        150        160        170        180
ATEKTLELEA LTRVVVHILD QNDLKPLFSP PSYRVTISED MPLKSPICKV TATDADLGQN
       190        200        210        220        230        240
AEFYYAFNTR SEMFAIHPTS GVVTVAGKLN VTWRGKHELQ VLAVDRMRKI SEGNGFGSLA
       250        260        270        280        290        300
ALVVHVEPAL RKPPAIASVV VTPPDSNDGT TYATVLVDAN SSGAEVESVE VVGGDPGKHF
       310        320        330        340        350        360
KAIKSYARSN EFSLVSVKDI NWMEYLHGFN LSLQARSGSG PYFYSQIRGF HLPPSKLSSL
       370        380        390        400        410        420
KFEKAVYRVQ LSEFSPPGSR VVMVRVTPAF PNLQYVLKPS SENVGFKLNA RTGLITTTKL
       430        440        450        460        470        480
MDFHDRAHYQ LHIRTSPGQA STVVVIDIVD CNNHAPLFNR SSYDGTLDEN IPPGTSVLAV
       490        500        510        520        530        540
TATDRDHGEN GYVTYSIAGP KALPFSIDPY LGIISTSKPM DYELMKRIYT FRVRASDWGS
       550        560        570        580        590        600
PFRREKEVSI FLQLRNLNDN QPMFEEVNCT GSIRQDWPVG KSIMTMSAID VDELQNLKYE
       610        620        630        640        650        660
IVSGNELEYF DLNHFSGVIS LKRPFINLTA GQPTSYSLKI TASDGKNYAS PTTLNITVVK
       670        680        690        700        710        720
DPHFEVPVTC DKTGVLTQFT KTILHFIGLQ NQESSDEEFT SLSTYQINHY TPQFEDHFPQ
       730        740        750        760        770        780
SIDVLESVPI NTPLARLAAT DPDAGFNGKL VYVIADGNEE GCFDIELETG LLTVAAPLDY
       790        800        810        820        830        840
EATNFYILNV TVYDLGTPQK SSWKLLTVNV KDWNDNAPRF PPGGYQLTIS EDTEVGTTIA
       850        860        870        880        890        900
ELTTKDADSE DNGRVRYTLL SPTEKFSLHP LTGELVVTGH LDRESEPRYI LKVEARDQPS
       910        920        930        940        950        960
KGHQLFSVTD LIITLEDVND NSPQCITEHN RLKVPEDLPP GTVLTFLDAS DPDLGPAGEV
       970        980        990       1000       1010       1020
RYVLMDGAHG TFRVDLMTGA LILERELDFE RRAGYNLSLW ASDGGRPLAR RTLCHVEVIV
      1030       1040       1050       1060       1070       1080
LDVNENLHPP HFASFVHQGQ VQENSPSGTQ VIVVAAQDDD SGLDGELQYF LRAGTGLAAF
      1090       1100       1110       1120       1130       1140
SINQDTGMIQ TLAPLDREFA SYYWLTVLAV DRGSVPLSSV TEVYIEVTDA NDNPPQMSQA
      1150       1160       1170       1180       1190       1200
VFYPSIQEDA PVGTSVLQLD AWDPDSSSKG KLTFNITSGN YMGFFMIHPV TGLLSTAQQL
      1210       1220       1230       1240       1250       1260
DRENKDEHIL EVTVLDNGEP SLKSTSRVVV GILDVNDNPP IFSHKLFNVR LPERLSPVSP
      1270       1280       1290       1300       1310       1320
GPVYRLVASD LDEGLNGRVT YSIEDSDEEA FSIDLVTGVV SSSSTFTAGE YNILTIKATD
      1330       1340       1350       1360       1370       1380
SGQPPLSASV RLHIEWIPWP RPSSIPLAFD ETYYSFTVME TDPVNHMVGV ISVEGRPGLF
      1390       1400       1410       1420       1430       1440
WFNISGGDKD MDFDIEKTTG SIVIARPLDT RRRSNYNLTV EVTDGSRTIA TQVHIFMIAN
      1450       1460       1470       1480       1490       1500
INHHRPQFLE TRYEVRVPQD TVPGVELLRV QAIDQDKGKS LIYTIHGSQD PGSASLFQLD
      1510       1520       1530       1540       1550       1560
PSSGVLVTVG KLDLGSGPSQ HTLTVMVRDQ EIPIKRNFVW VTIHVEDGNL HPPRFTQLHY
      1570       1580       1590       1600       1610       1620
EASVPDTIAP GTELLQVRAM DADRGVNAEV HYSLLKGNSE GFFNINALLG IITLAQKLDQ
      1630       1640       1650       1660       1670       1680
ANHAPHTLTV KAEDQGSPQW HDLATVIIHV YPSDRSAPIF SKSEYFVEIP ESIPVGSPIL
      1690       1700       1710       1720       1730       1740
LVSAMSPSEV TYELREGNKD GVFSMNSYSG LISTQKKLDH EKISSYQLKI RGSNMAGAFT
      1750       1760       1770       1780       1790       1800
DVMVVVDIID ENDNAPMFLK STFVGQISEA APLYSMIMDK NNNPFVIHAS DSDKEANSLL
      1810       1820       1830       1840       1850       1860
VYKILEPEAL KFFKIDPSMG TLTIVSEMDY ESMPSFQFCV YVHDQGSPVL FAPRPAQVII
      1870       1880       1890       1900       1910       1920
HVRDVNDSPP RFSEQIYEVA IVGPIHPGME LLMVRASDED SEVNYSIKTG NADEAVTIHP
      1930       1940       1950       1960       1970       1980
VTGSISVLNP AFLGLSRKLT IRASDGLYQD TALVKISLTQ VLDKSLQFDQ DVYWAAVKEN
      1990       2000       2010       2020       2030       2040
LQDRKALVIL GAQGNHLNDT LSYFLLNGTD MFHMVQSAGV LQTRGVAFDR EQQDTHELAV
      2050       2060       2070       2080       2090       2100
EVRDNRTPQR VAQGLVRVSI EDVNDNPPKF KHLPYYTIIQ DGTEPGDVLF QVSATDEDLG
      2110       2120       2130       2140       2150       2160
TNGAVTYEFA EDYTYFRIDP YLGDISLKKP FDYQALNKYH LKVIARDGGT PSLQSEEEVL
      2170       2180       2190       2200       2210       2220
VTVRNKSNPL FQSPYYKVRV PENITLYTPI LHTQARSPEG LRLIYNIVEE EPLMLFTTDF
      2230       2240       2250       2260       2270       2280
KTGVLTVTGP LDYESKTKHV FTVRATDTAL GSFSEATVEV LVEDVNDNPP TFSQLVYTTS
      2290       2300       2310       2320       2330       2340
ISEGLPAQTP VIQLLASDQD SGRNRDVSYQ IVEDGSDVSK FFQINGSTGE MSTVQELDYE
      2350       2360       2370       2380       2390       2400
AQQHFHVKVR AMDKGDPPLT GETLVVVNVS DINDNPPEFR QPQYEANVSE LATCGHLVLK
      2410       2420       2430       2440       2450       2460
VQAIDPDSRD TSRLEYLILS GNQDRHFFIN SSSGIISMFN LCKKHLDSSY NLRVGASDGV
      2470       2480       2490       2500       2510       2520
FRATVPVYIN TTNANKYSPE FQQHLYEAEL AENAMVGTKV IDLLAIDKDS GPYGTIDYTI
      2530       2540       2550       2560       2570       2580
INKLASEKFS INPNGQIATL QKLDRENSTE RVIAIKVMAR DGGGRVAFCT VKIILTDEND
      2590       2600       2610       2620       2630       2640
NPPQFKASEY TVSIQSNVSK DSPVIQVLAY DADEGQNADV TYSVNPEDLV KDVIEINPVT
      2650       2660       2670       2680       2690       2700
GVVKVKDSLV GLENQTLDFF IKAQDGGPPH WNSLVPVRLQ VVPKKVSLPK FSEPLYTFSA
      2710       2720       2730       2740       2750       2760
PEDLPEGSEI GIVKAVAAQD PVIYSLVRGT TPESNKDGVF SLDPDTGVIK VRKPMDHEST
      2770       2780       2790       2800       2810       2820
KLYQIDVMAH CLQNTDVVSL VSVNIQVGDV NDNRPVFEAD PYKAVLTENM PVGTSVIQVT
      2830       2840       2850       2860       2870       2880
AIDKDTGRDG QVSYRLSADP GSNVHELFAI DSESGWITTL QELDCETCQT YHFHVVAYDH
      2890       2900       2910       2920       2930       2940
GQTIQLSSQA LVQVSITDEN DNAPRFASEE YRGSVVENSE PGELVATLKT LDADISEQNR
      2950       2960       2970       2980       2990       3000
QVTCYITEGD PLGQFGISQV GDEWRISSRK TLDREHTAKY LLRVTASDGK FQASVTVEIF
      3010       3020       3030       3040       3050       3060
VLDVNDNSPQ CSQLLYTGKV HEDVFPGHFI LKVSATDLDT DTNAQITYSL HGPGAHEFKL
      3070       3080       3090       3100       3110       3120
DPHTGELTTL TALDRERKDV FNLVAKATDG GGRSCQADIT LHVEDVNDNA PRFFPSHCAV
      3130       3140       3150       3160       3170       3180
AVFDNTTVKT PVAVVFARDP DQGANAQVVY SLPDSAEGHF SIDATTGVIR LEKPLQVRPQ
      3190       3200       3210       3220       3230       3240
APLELTVRAS DLGTPIPLST LGTVTVSVVG LEDYLPVFLN TEHSVQVPED APPGTEVLQL
      3250       3260       3270       3280       3290       3300
ATLTRPGAEK TGYRVVSGNE QGRFRLDART GILYVNASLD FETSPKYFLS IECSRKSSSS
      3310       3320       3330       3340       3350       3360
LSDVTTVMVN ITDVNEHRPQ FPQDPYSTRV LENALVGDVI LTVSATDEDG PLNSDITYSL
      3370       3380       3390       3400       3410       3420
IGGNQLGHFT IHPKKGELQV AKALDREQAS SYSLKLRATD SGQPPLHEDT DIAIQVADVN
      3430       3440       3450       3460       3470       3480
DNPPRFFQLN YSTTVQENSP IGSKVLQLIL SDPDSPENGP PYSFRITKGN NGSAFRVTPD
      3490       3500       3510       3520       3530       3540
GWLVTAEGLS RRAQEWYQLQ IQASDSGIPP LSSLTSVRVH VTEQSHYAPS ALPLEIFITV
      3550       3560       3570       3580       3590       3600
GEDEFQGGMV GKIHATDRDP QDTLTYSLAE EETLGRHFSV GAPDGKIIAA QGLPRGHYSF
      3610       3620       3630       3640       3650       3660
NVTVSDGTFT TTAGVHVYVW HVGQEALQQA MWMGFYQLTP EELVSDHWRN LQRFLSHKLD
      3670       3680       3690       3700       3710       3720
IKRANIHLAS LQPAEAVAGV DVLLVFEGHS GTFYEFQELA SIITHSAKEM EHSVGVQMRS
      3730       3740       3750       3760       3770       3780
AMPMVPCQGP TCQGQICHNT VHLDPKVGPT YSTARLSILT PRHHLQRSCS CNGTATRFSG
      3790       3800       3810       3820       3830       3840
QSYVRYRAPA ARNWHIHFYL KTLQPQAILL FTNETASVSL KLASGVPQLE YHCLGGFYGN
      3850       3860       3870       3880       3890       3900
LSSQRHVNDH EWHSILVEEM DASIRLMVDS MGNTSLVVPE NCRGLRPERH LLLGGLILLH
      3910       3920       3930       3940       3950       3960
SSSNVSQGFE GCLDAVVVNE EALDLLAPGK TVAGLLETQA LTQCCLHSDY CSQNTCLNGG
      3970       3980       3990       4000       4010       4020
KCSWTHGAGY VCKCPPQFSG KHCEQGRENC TFAPCLEGGT CILSPKGASC NCPHPYTGDR
      4030       4040       4050       4060       4070       4080
CEMEARGCSE GHCLVTPEIQ RGDWGQQELL IITVAVAFII ISTVGLLFYC RRCKSHKPVA
      4090       4100       4110       4120       4130       4140
MEDPDLLARS VGVDTQAMPA IELNPLSASS CNNLNQPEPS KASVPNELVT FGPNSKQRPV
      4150       4160       4170       4180       4190       4200
VCSVPPRLPP AAVPSHSDNE PVIKRTWSSE EMVYPGGAMV WPPTYSRNER WEYPHSEVTQ
      4210       4220       4230       4240       4250       4260
GPLPPSAHRH STPVVMPEPN GLYGGFPFPL EMENKRAPLP PRYSNQNLED LMPSRPPSPR
      4270       4280       4290       4300       4310       4320
ERLVAPCLNE YTAISYYHSQ FRQGGGGPCL ADGGYKGVGM RLSRAGPSYA VCEVEGAPLA
      4330       4340
GQGQPRVPPN YEGSDMVESD YGSCEEVMF

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NYQ8-19-unknown	EKPLEG...	19	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NYQ8-2509-	DSGPYG...	2509		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NYQ8-2665-unknown	DGGPPH...	2665	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19824
Q9NYQ8-2742-unknown	LDPDTG...	2742	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19825
Q9NYQ8-2742-unknown	LDPDTG...	2742	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18149

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FIKAQD	2664	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19824
...DGVFSL	2741	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19825
...DGVFSL	2741	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18149
...EEVMF	4349	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	2664	KAQD.\|.DGGP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	2741	VFSL.\|.LDPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	2741	VFSL.\|.LDPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)