Q6YHK3: CD109 antigen

General Information

Protein names	- CD109 antigen - 150 kDa TGF-beta-1-binding protein - C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7 - Platelet-specific Gov antigen - p180 - r150 - CD109
Gene names	CD109
Organism	Homo sapiens
Protease Family
Protease ID	I39.006
Chromosome location
UniProt ID	Q6YHK3

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA
        70         80         90        100        110        120
ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST
       130        140        150        160        170        180
RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL
       190        200        210        220        230        240
SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS
       250        260        270        280        290        300
MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK
       310        320        330        340        350        360
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL
       370        380        390        400        410        420
KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY
       430        440        450        460        470        480
TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG
       490        500        510        520        530        540
SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG
       550        560        570        580        590        600
EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN
       610        620        630        640        650        660
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY
       670        680        690        700        710        720
AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW
       730        740        750        760        770        780
VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV
       790        800        810        820        830        840
KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT
       850        860        870        880        890        900
ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI
       910        920        930        940        950        960
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG
       970        980        990       1000       1010       1020
YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH
      1030       1040       1050       1060       1070       1080
QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS
      1090       1100       1110       1120       1130       1140
RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL
      1150       1160       1170       1180       1190       1200
DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT
      1210       1220       1230       1240       1250       1260
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF GFAICQLNVV
      1270       1280       1290       1300       1310       1320
YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN VCTSFSGPGR SGMALMEVNL
      1330       1340       1350       1360       1370       1380
LSGFMVPSEA ISLSETVKKV EYDHGKLNLY LDSVNETQFC VNIPAVRNFK VSNTQDASVS
      1390       1400       1410       1420       1430       1440
IVDYYEPRRQ AVRSYNSEVK LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF

MELWL

Isoforms

- Isoform 2 of CD109 antigen - Isoform 3 of CD109 antigen - Isoform 4 of CD109 antigen

Sequence View

        10         20         30         40         50         60
MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA
        70         80         90        100        110        120
ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST
       130        140        150        160        170        180
RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL
       190        200        210        220        230        240
SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS
       250        260        270        280        290        300
MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK
       310        320        330        340        350        360
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL
       370        380        390        400        410        420
KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY
       430        440        450        460        470        480
TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG
       490        500        510        520        530        540
SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG
       550        560        570        580        590        600
EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN
       610        620        630        640        650        660
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY
       670        680        690        700        710        720
AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW
       730        740        750        760        770        780
VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV
       790        800        810        820        830        840
KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT
       850        860        870        880        890        900
ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI
       910        920        930        940        950        960
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG
       970        980        990       1000       1010       1020
YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH
      1030       1040       1050       1060       1070       1080
QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS
      1090       1100       1110       1120       1130       1140
RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL
      1150       1160       1170       1180       1190       1200
DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT
      1210       1220       1230       1240       1250       1260
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF GFAICQLNVV
      1270       1280       1290       1300       1310       1320
YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN VCTSFSGPGR SGMALMEVNL
      1330       1340       1350       1360       1370       1380
LSGFMVPSEA ISLSETVKKV EYDHGKLNLY LDSVNETQFC VNIPAVRNFK VSNTQDASVS
      1390       1400       1410       1420       1430       1440
IVDYYEPRRQ AVRSYNSEVK LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF

MELWL         10         20         30         40         50         60
MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA
        70         80         90        100        110        120
ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST
       130        140        150        160        170        180
RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL
       190        200        210        220        230        240
SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS
       250        260        270        280        290        300
MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK
       310        320        330        340        350        360
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL
       370        380        390        400        410        420
KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY
       430        440        450        460        470        480
TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG
       490        500        510        520        530        540
SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG
       550        560        570        580        590        600
EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN
       610        620        630        640        650        660
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY
       670        680        690        700        710        720
AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW
       730        740        750        760        770        780
VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV
       790        800        810        820        830        840
KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT
       850        860        870        880        890        900
ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI
       910        920        930        940        950        960
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG
       970        980        990       1000       1010       1020
YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH
      1030       1040       1050       1060       1070       1080
QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS
      1090       1100       1110       1120       1130       1140
RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL
      1150       1160       1170       1180       1190       1200
DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT
      1210       1220       1230       1240       1250       1260
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF GFAICQLNVV
      1270       1280       1290       1300       1310       1320
YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN VCTSFSGPGR SGMALMEVNL
      1330       1340       1350       1360       1370       1380
LSGFMVPSEA ISLSETVKKV EYDHGKLNLY LDSVNETQFC VNIPAVRNFK VSNTQDASVS
      1390       1400       1410       1420       1430       1440
IVDYYEPRRQ AVRSYNSEVK LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF

MELWL         10         20         30         40         50         60
MQGPPLLTAA HLLCVCTAAL AVAPGPRFLV TAPGIIRPGG NVTIGVELLE HCPSQVTVKA
        70         80         90        100        110        120
ELLKTASNLT VSVLEAEGVF EKGSFKTLTL PSLPLNSADE IYELRVTGRT QDEILFSNST
       130        140        150        160        170        180
RLSFETKRIS VFIQTDKALY KPKQEVKFRI VTLFSDFKPY KTSLNILIKD PKSNLIQQWL
       190        200        210        220        230        240
SQQSDLGVIS KTFQLSSHPI LGDWSIQVQV NDQTYYQSFQ VSEYVLPKFE VTLQTPLYCS
       250        260        270        280        290        300
MNSKHLNGTI TAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSA NFSFNDEEMK
       310        320        330        340        350        360
NVMDSSNGLS EYLDLSSPGP VEILTTVTES VTGISRNVST NVFFKQHDYI IEFFDYTTVL
       370        380        390        400        410        420
KPSLNFTATV KVTRADGNQL TLEERRNNVV ITVTQRNYTE YWSGSNSGNQ KMEAVQKINY
       430        440        450        460        470        480
TVPQSGTFKI EFPILEDSSE LQLKAYFLGS KSSMAVHSLF KSPSKTYIQL KTRDENIKVG
       490        500        510        520        530        540
SPFELVVSGN KRLKELSYMV VSRGQLVAVG KQNSTMFSLT PENSWTPKAC VIVYYIEDDG
       550        560        570        580        590        600
EIISDVLKIP VQLVFKNKIK LYWSKVKAEP SEKVSLRISV TQPDSIVGIV AVDKSVNLMN
       610        620        630        640        650        660
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDANLTKDY IDGVYDNAEY
       670        680        690        700        710        720
AERFMEENEG HIVDIHDFSL GSSPHVRKHF PETWIWLDTN MGYRIYQEFE VTVPDSITSW
       730        740        750        760        770        780
VATGFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEITI FNYLKDATEV
       790        800        810        820        830        840
KVIIEKSDKF DILMTSNEIN ATGHQQTLLV PSEDGATVLF PIRPTHLGEI PITVTALSPT
       850        860        870        880        890        900
ASDAVTQMIL VKAEGIEKSY SQSILLDLTD NRLQSTLKTL SFSFPPNTVT GSERVQITAI
       910        920        930        940        950        960
GDVLGPSING LASLIRMPYG CGEQNMINFA PNIYILDYLT KKKQLTDNLK EKALSFMRQG
       970        980        990       1000       1010       1020
YQRELLYQRE DGSFSAFGNY DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGH
      1030       1040       1050       1060       1070       1080
QKSNGEFWDP GRVIHSELQG GNKSPVTLTA YIVTSLLGYR KYQPNIDVQE SIHFLESEFS
      1090       1100       1110       1120       1130       1140
RGISDNYTLA LITYALSSVG SPKAKEALNM LTWRAEQEGG MQFWVSSESK LSDSWQPRSL
      1150       1160       1170       1180       1190       1200
DIEVAAYALL SHFLQFQTSE GIPIMRWLSR QRNSLGGFAS TQDTTVALKA LSEFAALMNT
      1210       1220       1230       1240       1250       1260
ERTNIQVTVT GPSSPSPVKF LIDTHNRLLL QTAELAVVQP TAVNISANGF GFAICQLNVV
      1270       1280       1290       1300       1310       1320
YNVKASGSSR RRRSIQNQEA FDLDVAVKEN KDDLNHVDLN VCTSFSGPGR SGMALMEVNL
      1330       1340       1350       1360       1370       1380
LSGFMVPSEA ISLSETVKKV EYDHGKLNLY LDSVNETQFC VNIPAVRNFK VSNTQDASVS
      1390       1400       1410       1420       1430       1440
IVDYYEPRRQ AVRSYNSEVK LSSCDLCSDV QGCRPCEDGA SGSHHHSSVI FIFCFKLLYF

MELWL

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6YHK3-1-unknown	MQGPPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69846
Q6YHK3-1-unknown	MQGPPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69847
Q6YHK3-1-unknown	MQGPPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69848
Q6YHK3-22-unknown	VAPGPR...	22	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6YHK3-22-unknown	VAPGPR...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112923
Q6YHK3-22-unknown	VAPGPR...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112924
Q6YHK3-22-unknown	VAPGPR...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112925
Q6YHK3-669-unknown	EGHIVD...	669	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19644
Q6YHK3-669-unknown	EGHIVD...	669	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154495
Q6YHK3-669-unknown	EGHIVD...	669	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155539
Q6YHK3-670-unknown	GHIVDI...	670	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177312
Q6YHK3-670-unknown	GHIVDI...	670	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177311
Q6YHK3-670-	GHIVDI...	670		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q6YHK3-1284-unknown	DVAVKE...	1284	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19647
Q6YHK3-1284-unknown	DVAVKE...	1284	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157686
Q6YHK3-1284-unknown	DVAVKE...	1284	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157854

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FMEENE	668	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19644
...FMEENE	668	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137917
...FMEENE	668	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138977
...EAFDLD	1283	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19647
...EAFDLD	1283	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141185
...EAFDLD	1283	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141351
...CEDGAS	1420	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CEDGAS	1420	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93747
...CEDGAS	1420	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93746
...MELWL	1445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65464
...MELWL	1445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65466

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	668	EENE.\|.EGHI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	1283	FDLD.\|.DVAV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

TopFIND

Q6YHK3: CD109 antigen

General Information

6

N-termini

4

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates