P06744: Glucose-6-phosphate isomerase

General Information

Protein names	- Glucose-6-phosphate isomerase - GPI - 5.3.1.9 - Autocrine motility factor - AMF - Neuroleukin - NLK - Phosphoglucose isomerase - PGI - Phosphohexose isomerase - PHI - Sperm antigen 36 - SA-36
Gene names	GPI
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06744

16 N-termini

10 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAALTRDPQF QKLQQWYREH RSELNLRRLF DANKDRFNHF SLTLNTNHGH ILVDYSKNLV
        70         80         90        100        110        120
TEDVMRMLVD LAKSRGVEAA RERMFNGEKI NYTEGRAVLH VALRNRSNTP ILVDGKDVMP
       130        140        150        160        170        180
EVNKVLDKMK SFCQRVRSGD WKGYTGKTIT DVINIGIGGS DLGPLMVTEA LKPYSSGGPR
       190        200        210        220        230        240
VWYVSNIDGT HIAKTLAQLN PESSLFIIAS KTFTTQETIT NAETAKEWFL QAAKDPSAVA
       250        260        270        280        290        300
KHFVALSTNT TKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHVGF DNFEQLLSGA
       310        320        330        340        350        360
HWMDQHFRTT PLEKNAPVLL ALLGIWYINC FGCETHAMLP YDQYLHRFAA YFQQGDMESN
       370        380        390        400        410        420
GKYITKSGTR VDHQTGPIVW GEPGTNGQHA FYQLIHQGTK MIPCDFLIPV QTQHPIRKGL
       430        440        450        460        470        480
HHKILLANFL AQTEALMRGK STEEARKELQ AAGKSPEDLE RLLPHKVFEG NRPTNSIVFT
       490        500        510        520        530        540
KLTPFMLGAL VAMYEHKIFV QGIIWDINSF DQWGVELGKQ LAKKIEPELD GSAQVTSHDA
       550
STNGLINFIK QQREARVQ

Isoforms

- Isoform 2 of Glucose-6-phosphate isomerase

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 10 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06744-1-unknown	MAALTR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98880
P06744-2-unknown	MAALTR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06744-2-Acetylation	AALTRD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06744-2-Acetylation	AALTRD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110422
P06744-46-unknown	TNHGHI...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5417
P06744-46-unknown	TNHGHI...	46		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141554
P06744-184-unknown	VSNIDG...	184		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5419
P06744-184-unknown	VSNIDG...	184		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146421
P06744-185-unknown	SNIDGT...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5421
P06744-185-unknown	SNIDGT...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146453
P06744-186-unknown	NIDGTH...	186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7211
P06744-186-unknown	NIDGTH...	186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5423
P06744-186-unknown	NIDGTH...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146484
P06744-215-unknown	TQETIT...	215		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7213
P06744-215-unknown	TQETIT...	215		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5425
P06744-215-unknown	TQETIT...	215		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147575
P06744-387-unknown	GQHAFY...	387		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176566
P06744-387-	GQHAFY...	387			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P06744-405-unknown	DFLIPV...	405		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18531
P06744-405-unknown	DFLIPV...	405		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152262
P06744-406-unknown	FLIPVQ...	406		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3511
P06744-406-unknown	FLIPVQ...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152286
P06744-470-unknown	GNRPTN...	470		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5427
P06744-470-unknown	GNRPTN...	470		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153198
P06744-509-	SFDQWG...	509			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06744-509-	SFDQWG...	509			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06744-509-unknown	SFDQWG...	509		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168519
P06744-539-unknown	DASTNG...	539		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18533
P06744-539-unknown	DASTNG...	539		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153988

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SLTLNT	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5417
...SLTLNT	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124731
...PRVWYV	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5419
...PRVWYV	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129726
...RVWYVS	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5421
...RVWYVS	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129758
...VWYVSN	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7211
...VWYVSN	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5423
...VWYVSN	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129792
...SKTFTT	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7213
...SKTFTT	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5425
...SKTFTT	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130927
...KMIPCD	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18531
...KMIPCD	404	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135672
...MIPCDF	405	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3511
...MIPCDF	405	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135696
...HKVFEG	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5427
...HKVFEG	469	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136624
...QVTSHD	538	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18533
...QVTSHD	538	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137409
...EARVQ	558	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EARVQ	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71263

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	45	TLNT.\|.TNHG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	183	VWYV.\|.VSNI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	184	WYVS.\|.SNID	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	185	YVSN.\|.NIDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	185	YVSN.\|.NIDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	214	TFTT.\|.TQET	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	214	TFTT.\|.TQET	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	404	IPCD.\|.DFLI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	405	PCDF.\|.FLIP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	469	VFEG.\|.GNRP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	538	TSHD.\|.DAST	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)