Q9BZZ5: Apoptosis inhibitor 5

General Information

Protein names	- Apoptosis inhibitor 5 - API-5 - Antiapoptosis clone 11 protein - AAC-11 - Cell migration-inducing gene 8 protein - Fibroblast growth factor 2-interacting factor - FIF - Protein XAGL
Gene names	API5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BZZ5

4 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Apoptosis inhibitor 5 - Isoform 2 of Apoptosis inhibitor 5 - Isoform 3 of Apoptosis inhibitor 5 - Isoform 5 of Apoptosis inhibitor 5 - Isoform 6 of Apoptosis inhibitor 5

Sequence View

        10         20         30         40         50         60
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA
        70         80         90        100        110        120
DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA
       130        140        150        160        170        180
LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK
       190        200        210        220        230        240
KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ
       250        260        270        280        290        300
CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM
       310        320        330        340        350        360
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF
       370        380        390        400        410        420
LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN
       430        440        450        460        470        480
INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRASEDT TSGSPPKKSS AGPKRDARQI
       490        500        510        520
YNPPSGKYSS NLGNFNYEQR GAFRGSRGGR GWGTRGNRSR GRLY         10         20         30         40         50         60
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA
        70         80         90        100        110        120
DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA
       130        140        150        160        170        180
LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK
       190        200        210        220        230        240
KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ
       250        260        270        280        290        300
CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM
       310        320        330        340        350        360
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF
       370        380        390        400        410        420
LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN
       430        440        450        460        470        480
INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRASEDT TSGSPPKKSS AGPKRDARQI
       490        500        510        520
YNPPSGKYSS NLGNFNYEQR GAFRGSRGGR GWGTRGNRSR GRLY         10         20         30         40         50         60
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA
        70         80         90        100        110        120
DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA
       130        140        150        160        170        180
LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK
       190        200        210        220        230        240
KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ
       250        260        270        280        290        300
CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM
       310        320        330        340        350        360
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF
       370        380        390        400        410        420
LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN
       430        440        450        460        470        480
INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRASEDT TSGSPPKKSS AGPKRDARQI
       490        500        510        520
YNPPSGKYSS NLGNFNYEQR GAFRGSRGGR GWGTRGNRSR GRLY         10         20         30         40         50         60
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA
        70         80         90        100        110        120
DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA
       130        140        150        160        170        180
LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK
       190        200        210        220        230        240
KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ
       250        260        270        280        290        300
CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM
       310        320        330        340        350        360
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF
       370        380        390        400        410        420
LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN
       430        440        450        460        470        480
INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRASEDT TSGSPPKKSS AGPKRDARQI
       490        500        510        520
YNPPSGKYSS NLGNFNYEQR GAFRGSRGGR GWGTRGNRSR GRLY         10         20         30         40         50         60
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA
        70         80         90        100        110        120
DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA
       130        140        150        160        170        180
LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK
       190        200        210        220        230        240
KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ
       250        260        270        280        290        300
CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM
       310        320        330        340        350        360
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF
       370        380        390        400        410        420
LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN
       430        440        450        460        470        480
INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRASEDT TSGSPPKKSS AGPKRDARQI
       490        500        510        520
YNPPSGKYSS NLGNFNYEQR GAFRGSRGGR GWGTRGNRSR GRLY

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BZZ5-1-unknown	MPTVEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67227
Q9BZZ5-1-unknown	MPTVEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67228
Q9BZZ5-1-unknown	MPTVEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67229
Q9BZZ5-2-unknown	PTVEEL...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BZZ5-2-unknown	PTVEEL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BZZ5-2-unknown	PTVEEL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BZZ5-2-unknown	PTVEEL...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110387
Q9BZZ5-2-unknown	PTVEEL...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110388
Q9BZZ5-2-unknown	PTVEEL...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110389
Q9BZZ5-13-unknown	ILADAT...	13	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6760
Q9BZZ5-13-unknown	ILADAT...	13	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136421
Q9BZZ5-13-unknown	ILADAT...	13	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136422
Q9BZZ5-16-unknown	DATEQV...	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19780
Q9BZZ5-16-unknown	DATEQV...	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6764
Q9BZZ5-16-unknown	DATEQV...	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8076
Q9BZZ5-16-unknown	DATEQV...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136577
Q9BZZ5-16-unknown	DATEQV...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136578

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YRNYGI	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6760
...YGILAD	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19780
...YGILAD	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6764
...YGILAD	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8076
...RGRLY	524	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	12	NYGI.\|.ILAD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	15	ILAD.\|.DATE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	15	ILAD.\|.DATE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	15	ILAD.\|.DATE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)