P15311: Ezrin

General Information

Protein names	- Ezrin - Cytovillin - Villin-2 - p81
Gene names	EZR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P15311

11 N-termini

8 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK
        70         80         90        100        110        120
LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE
       130        140        150        160        170        180
TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR
       190        200        210        220        230        240
GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF
       250        260        270        280        290        300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI
       310        320        330        340        350        360
EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTKK
       370        380        390        400        410        420
AERELSEQIQ RALQLEEERK RAQEEAERLE ADRMAALRAK EELERQAVDQ IKSQEQLAAE
       430        440        450        460        470        480
LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP
       490        500        510        520        530        540
VSYHVQESLQ DEGAEPTGYS AELSSEGIRD DRNEEKRITE AEKNERVQRQ LLTLSSELSQ
       550        560        570        580
ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 8 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P15311-2-unknown	PKPINV...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P15311-2-unknown	PKPINV...	2	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P15311-2-unknown	PKPINV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P15311-2-unknown	PKPINV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P15311-232-unknown	DKLTPK...	232	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2543
P15311-263-	KAPDFV...	263		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P15311-263-	KAPDFV...	263		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P15311-393-unknown	RMAALR...	393	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2544
P15311-419-unknown	AELAEY...	419	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18759
P15311-419-unknown	AELAEY...	419	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17366
P15311-423-unknown	EYTAKI...	423	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18760
P15311-423-unknown	EYTAKI...	423	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17367
P15311-440-unknown	DEVEEW...	440	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18761
P15311-440-unknown	DEVEEW...	440	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17368
P15311-441-unknown	EVEEWQ...	441	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18762
P15311-464-unknown	HLVMTA...	464	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13977
P15311-488-	SLQDEG...	488		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P15311-488-	SLQDEG...	488		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P15311-493-	GAEPTG...	493		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IYEKDD	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2543
...RLEADR	392	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2544
...QEQLAA	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18759
...QEQLAA	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17366
...AAELAE	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18760
...AAELAE	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17367
...RRRKED	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18761
...RRRKED	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17368
...RRKEDE	440	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18762
...TKEELH	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13977
...EFEAL	586	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	231	EKDD.\|.DKLT	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	392	EADR.\|.RMAA	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
MEP1B_HUMAN	418	QLAA.\|.AELA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	418	QLAA.\|.AELA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	422	ELAE.\|.EYTA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	422	ELAE.\|.EYTA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	439	RKED.\|.DEVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	439	RKED.\|.DEVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	440	KEDE.\|.EVEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	463	EELH.\|.HLVM	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)