P40227: T-complex protein 1 subunit zeta

General Information

Protein names	- T-complex protein 1 subunit zeta - TCP-1-zeta - Acute morphine dependence-related protein 2 - CCT-zeta-1 - HTR3 - Tcp20 {ECO:0000303\|PubMed:8034610}
Gene names	CCT6A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P40227

10 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG
        70         80         90        100        110        120
NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT
       130        140        150        160        170        180
EGFEAAKEKA LQFLEEVKVS REMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIK
       190        200        210        220        230        240
KQDEPIDLFM IEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE
       250        260        270        280        290        300
KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF
       310        320        330        340        350        360
SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV YEYTLGEEKF
       370        380        390        400        410        420
TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN AIDDGCVVPG AGAVEVAMAE
       430        440        450        460        470        480
ALIKHKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD
       490        500        510        520        530
LNTGEPMVAA EVGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G

Isoforms

- Isoform 2 of T-complex protein 1 subunit zeta

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P40227-2-unknown	MAAVKT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P40227-1-unknown	MAAVKT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91766
P40227-2-Acetylation	AAVKTL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P40227-2-Acetylation	AAVKTL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P40227-2-Acetylation	AAVKTL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P40227-2-Acetylation	AAVKTL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P40227-2-Acetylation	AAVKTL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110793
P40227-3-acetylation	AVKTLN...	3	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P40227-3-acetylation	AVKTLN...	3	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182715
P40227-66-unknown	EMQIQH...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19094
P40227-242-unknown	TEVNSG...	242		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164848
P40227-242-	TEVNSG...	242			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P40227-242-	TEVNSG...	242			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P40227-454-unknown	NSGFDL...	454		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3791
P40227-454-unknown	NSGFDL...	454		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152154
P40227-456-	GFDLQE...	456			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P40227-456-unknown	GFDLQE...	456		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177499

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...NVLLHE	65	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19094
...NVLLHE	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt153968
...KVLAQN	453	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3791
...KVLAQN	453	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135564
...SSLKG	531		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SSLKG	531		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SSLKG	531	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SSLKG	531	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt87384
...SSLKG	531		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SSLKG	531		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	65	LLHE.\|.EMQI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	453	LAQN.\|.NSGF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)