P32926: Desmoglein-3

General Information

Protein names	- Desmoglein-3 - 130 kDa pemphigus vulgaris antigen - PVA - Cadherin family member 6
Gene names	DSG3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P32926

6 N-termini

6 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMGLFPRTTG ALAIFVVVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE WVKFAKPCRE
        70         80         90        100        110        120
GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF VVDKNTGDIN ITAIVDREET
       130        140        150        160        170        180
PSFLITCRAL NAQGLDVEKP LILTVKILDI NDNPPVFSQQ IFMGEIEENS ASNSLVMILN
       190        200        210        220        230        240
ATDADEPNHL NSKIAFKIVS QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLVVSGA
       250        260        270        280        290        300
DKDGEGLSTQ CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN
       310        320        330        340        350        360
WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKALDYEQL QSVKLSIAVK NKAEFHQSVI
       370        380        390        400        410        420
SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK LVDYILGTYQ AIDEDTNKAA
       430        440        450        460        470        480
SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM NRDSTFIVNK TITAEVLAID EYTGKTSTGT
       490        500        510        520        530        540
VYVRVPDFND NCPTAVLEKD AVCSSSPSVV VSARTLNNRY TGPYTFALED QPVKLPAVWS
       550        560        570        580        590        600
ITTLNATSAL LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP
       610        620        630        640        650        660
TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG VTGGFIPVPD
       670        680        690        700        710        720
GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS EVCTNTYARG TAVEGTSGME
       730        740        750        760        770        780
MTTKLGAATE SGGAAGFATG TVSGAASGFG AATGVGICSS GQSGTMRTRH STGGTNKDYA
       790        800        810        820        830        840
DGAISMNFLD SYFSQKAFAC AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD
       850        860        870        880        890        900
LDDSFLDSLG PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT
       910        920        930        940        950        960
LSGSQGASAL STSGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG FDPLLTQNVI
       970        980        990
VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P32926-24-unknown	ELRIET...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P32926-29-unknown	TKGQYD...	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17600
P32926-34-unknown	DEEEMT...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17601
P32926-35-unknown	EEEMTM...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19059
P32926-35-unknown	EEEMTM...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17602
P32926-50-unknown	EWVKFA...	50	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P32926-50-unknown	EWVKFA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9763
P32926-50-unknown	EWVKFA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16341
P32926-782-unknown	GAISMN...	782	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1783

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELRIET	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17600
...TKGQYD	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17601
...KGQYDE	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19059
...KGQYDE	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17602
...RRQKRE	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9763
...RRQKRE	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16341
...KDYADG	781	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1783
...CSRLI	999	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	28	RIET.\|.TKGQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	33	GQYD.\|.DEEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	34	QYDE.\|.EEEM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	34	QYDE.\|.EEEM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
FURIN_HUMAN	49	QKRE.\|.EWVK	inferred from experiment	unknown	MEROPS	Muller E	Posthaus H et al.:Novel insights into cadherin pr... (S08.071)	12586364,
KLK4_HUMAN	49	QKRE.\|.EWVK	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
CASP3_HUMAN	781	YADG.\|.GAIS	inferred from experiment	unknown	MEROPS	Huber O	Weiske J et al.:The fate of desmosomal proteins... (C14.003)	11500511,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)